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Ahmet Eken

TitleAssistant Research Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Atuk Kahraman T, Yilmaz M, Aslan K, Canatan H, Kara A, Nalbantoglu OU, Gundogdu A, Eken A. Lycopene Supplemented Mediterranean Diet Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) in Mice and Changes Intestinal Microbiome. J Neuroimmune Pharmacol. 2025 May 05; 20(1):50. PMID: 40323426.
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    2. Yilmaz S, Eken A, Sezer Z, Bagci BS, Erdem S, Sarikaya MD, Kaplan B, Inal A, Bayram A, Kalin Unuvar G, Zararsiz G, Yerlitas SI, Cakir N, Pavel STI, Uygut MA, Yetiskin H, Kara A, Ozdarendeli A. Vaccination with inactivated SARS-CoV-2 vaccine TURKOVAC induces durable humoral and cellular immune responses up to 8?months. Front Med (Lausanne). 2025; 12:1524393. PMID: 40357274.
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    3. Uzen R, Bayram F, Dursun H, Kardas F, Cakir M, Cucer N, Eken A, Donmez-Altuntas H. The number and frequency of mucosal-associated invariant T (MAIT), ?d T, and innate lymphoid cells (ILCs) altered in patients with type I Gaucher disease. Hum Immunol. 2025 May; 86(3):111302. PMID: 40184787.
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    4. Erdem S, Yilmaz E, Ozcan A, Canatan AN, Bisgin A, Dogan ME, Karakukcu M, Unal E, Eken A. A novel loss of function mutation in the HAVCR2 gene in a patient diagnosed with Hodgkin's lymphoma. Immunol Res. 2025 Mar 14; 73(1):61. PMID: 40082338.
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    5. ?zen R, Bayram F, Dursun H, Kardas F, Cakir M, Hasan Sohel MM, Cucer N, Eken A, Donmez-Altuntas H. Tumor Suppressor and Oncogenic miRNA Expressions in Patients with Type I Gaucher Disease and Carriers. Microrna. 2025 Feb 26. PMID: 40012398.
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    6. Akyol S, Yilmaz E, Tokg?z H, Karaman K, Pekpak E, ?zcan A, Si Msek A, Arslan B, ?ren AC, G?k?eli HS, Acipayam C, G?zel T, Tuncel DA, G?k V, Arslan K, Eken A, Canatan H, Akbayram S, Karak?kc? M, Aycan N, ?aliskan ?, Patiroglu T, ?zdemi R MA, Chiang SCC, Bryceson YT, ?nal E. Clinical spectrum of primary hemophagocytic lymphohistiocytosis: experience of reference centers in Central and Southeast Anatolia. Ann Hematol. 2025 Jan; 104(1):123-130. PMID: 39579250.
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    7. Azizoglu ZB, Babayeva R, Haskologlu ZS, Acar MB, Ayaz-Guner S, Okus FZ, Alsavaf MB, Can S, Basaran KE, Canatan MF, Ozcan A, Erkmen H, Leblebici CB, Yilmaz E, Karakukcu M, Kose M, Canoz O, ?zen A, Karakoc-Aydiner E, Ceylaner S, G?m?s G, Per H, Gumus H, Canatan H, Ozcan S, Dogu F, Ikinciogullari A, Unal E, Baris S, Eken A. Correction to: DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans. J Clin Immunol. 2024 Nov 16; 45(1):43. PMID: 39547966.
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    8. Azizoglu ZB, Babayeva R, Haskologlu ZS, Acar MB, Ayaz-Guner S, Okus FZ, Alsavaf MB, Can S, Basaran KE, Canatan MF, Ozcan A, Erkmen H, Leblebici CB, Yilmaz E, Karakukcu M, Kose M, Canoz O, ?zen A, Karakoc-Aydiner E, Ceylaner S, G?m?s G, Per H, Gumus H, Canatan H, Ozcan S, Dogu F, Ikinciogullari A, Unal E, Baris S, Eken A. DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans. J Clin Immunol. 2024 08 09; 44(8):175. PMID: 39120629.
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    9. Sinmez CC, T?fek?i E, Demir BS, Eken A, Gunes V, Ekici S, Bozkaya E, Aykun AI. Investigation of immunomodulatory and cytotoxic effects of shed snake skin (Elaphe sauromates) extract. Front Pharmacol. 2024; 15:1270970. PMID: 39070782.
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    10. Dizdar OS, Erdem S, Deliktas ED, Dogan S, Gundogan K, Genton L, Canatan H, Eken A. Thiamine status and genes encoding intestinal thiamine transporters and transcription factors in obese subjects. Nutr Metab Cardiovasc Dis. 2024 Oct; 34(10):2369-2377. PMID: 39069468.
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    11. G?k V, Leblebisatan G, G?rlek G?k?ebay D, G?ler S, Dogan ME, Tug Bozdogan S, Koca Yozgat A, ?zcan A, Pekpak Sahinoglu E, Tokg?z H, ?il M, ?zemri Sag S, Yilmaz E, Sasmaz HI, Evim MS, Akbayram S, Karadogan M, Mutlu FT, Boga I, Yeter Dogan B, Yarali N, ?aliskan ?, Bisgin A, Temel SG, Proven M, Gibson K, Demir BS, Sara?oglu H, Eken A, Karak?k?? ?, Karak?k?? M, G?nes AM, ?zbek NY, Kilin? Y, Patiroglu T, ?zdemir MA, Roy NBA, ?nal E. Pyruvate kinase deficiency in 29 Turkish patients with two novel intronic variants. Br J Haematol. 2024 Jul; 205(1):236-242. PMID: 38811201.
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    12. Odabas GP, Aslan K, Suna PA, Kendirli PK, Erdem S, ?akir M, ?zcan A, Yilmaz E, Karakukcu M, Donmez-Altuntas H, Yay AH, Deniz K, Altay D, Arslan D, Canatan H, Eken A, Unal E. Alantolactone ameliorates graft versus host disease in mice. Int Immunopharmacol. 2024 Feb 15; 128:111560. PMID: 38246003.
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    13. Lanz AL, Erdem S, Ozcan A, Ceylaner G, Cansever M, Ceylaner S, Conca R, Magg T, Acuto O, Latour S, Klein C, Patiroglu T, Unal E, Eken A, Hauck F. Correction to: A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature. J Clin Immunol. 2024 Jan 16; 44(1):41. PMID: 38225415.
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    14. Lanz AL, Erdem S, Ozcan A, Ceylaner G, Cansever M, Ceylaner S, Conca R, Magg T, Acuto O, Latour S, Klein C, Patiroglu T, Unal E, Eken A, Hauck F. A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature. J Clin Immunol. 2023 12 15; 44(1):1. PMID: 38100037.
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    15. Ozcelik F, Aslan K, Gok V, Ari MB, Ozcan A, Eken A, ?nal E, Ozkul Y, Dundar M. A case of autoimmune lymphoproliferative syndrome with a novel de novo FAS variant. Pediatr Hematol Oncol. 2024 May; 41(4):301-309. PMID: 38047450.
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    16. Erdem S, Haskologlu S, Haliloglu Y, Celikzencir H, Arik E, Keskin O, Eltan SB, Yucel E, Canatan H, Avcilar H, Yilmaz E, Ozcan A, Unal E, Karakukcu M, Celiksoy MH, Kilic SS, Demir A, Genel F, Gulez N, Koker MY, Ozen AO, Baris S, Metin A, Guner SN, Reisli I, Keles S, Dogu EF, Ikinciogullari KA, Eken A. Defective Treg generation and increased type 3 immune response in leukocyte adhesion deficiency 1. Clin Immunol. 2023 08; 253:109691. PMID: 37433423.
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    17. Sahin A, Kocyigit I, Aslan K, Eroglu E, Demiray A, Eken A. Elevated checkpoint inhibitor expression and Treg cell number in autosomal dominant polycystic kidney disease and their correlation with disease parameters and hypertension. Clin Exp Med. 2023 Nov; 23(7):3631-3640. PMID: 36869968.
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    18. Uzen R, Bayram F, Dursun H, Kardas F, Cakir M, Cucer N, Eken A, Donmez-Altuntas H. Characterization of peripheral blood T follicular helper (TFH) cells in patients with type 1 Gaucher disease and carriers. Blood Cells Mol Dis. 2023 05; 100:102728. PMID: 36738539.
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    19. Senol H, Ozgun-Acar O, Dag A, Eken A, Guner H, Aykut ZG, Topcu G, Sen A. Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3?-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent. J Nat Prod. 2023 01 27; 86(1):103-118. PMID: 36598820.
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    20. Heydari Z, Peshkova M, Gonen ZB, Coretchi I, Eken A, Yay AH, Dogan ME, Gokce N, Akalin H, Kosheleva N, Galea-Abdusa D, Ulinici M, Vorojbit V, Shpichka A, Groppa S, Vosough M, Todiras M, Butnaru D, Ozkul Y, Timashev P. EVs vs. EVs: MSCs and Tregs as a source of invisible possibilities. J Mol Med (Berl). 2023 02; 101(1-2):51-63. PMID: 36527475.
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    21. G?k V, Erdem S, Haliloglu Y, Bisgin A, Belkaya S, Basaran KE, Canatan MF, ?zcan A, Yilmaz E, Acipayam C, Karak?kc? M, Canatan H, Per H, Patiroglu T, Eken A, ?nal E. Immunodeficiency associated with a novel functionally defective variant of SLC19A1 benefits from folinic acid treatment. Genes Immun. 2023 02; 24(1):12-20. PMID: 36517554.
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    22. G?l F, Gonen ZB, Jones OY, Tasli NP, Zararsiz G, ?nal E, ?zdarendeli A, Sahin F, Eken A, Yilmaz S, Karakuk?u M, Kirbas OK, G?kdemir NS, Bozkurt BT, ?zkul Y, Oktay BD, Uygut MA, Cinel I, ?etin M. A pilot study for treatment of severe COVID-19 pneumonia by aerosolized formulation of convalescent human immune plasma exosomes (ChipEXO?). Front Immunol. 2022; 13:963309. PMID: 36439138.
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    23. Uzen R, Bayram F, Dursun H, Kardas F, Altin-Celik P, Cakir M, Eken A, Cucer N, Donmez-Altuntas H. Oxidative and chromosomal DNA damage in patients with type I Gaucher disease and carriers. Clin Biochem. 2023 Jan; 111:26-31. PMID: 36257477.
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    24. Koseoglu E, Sungur N, Muhtaroglu S, Zararsiz G, Eken A. The Beneficial Clinical Effects of Teriflunomide in Experimental Autoimmune Myasthenia Gravis and the Investigation of the Possible Immunological Mechanisms. Cell Mol Neurobiol. 2023 Jul; 43(5):2071-2087. PMID: 36219379.
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    25. Haliloglu Y, Ozcan A, Erdem S, Azizoglu ZB, Bicer A, Ozarslan OY, Kilic O, Okus FZ, Demir F, Canatan H, Karakukcu M, Uludag SZ, Kutuk MS, Unal E, Eken A. Characterization of cord blood CD3+ TCRVa7.2+ CD161high T and innate lymphoid cells in the pregnancies with gestational diabetes, morbidly adherent placenta, and pregnancy hypertension diseases. Am J Reprod Immunol. 2022 07; 88(1):e13555. PMID: 35452164.
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    26. Kasap N, Aslan K, Karakurt LT, Bozkurt H, Canatan H, Cavkaytar O, Eken A, Arga M. A novel gain-of-function mutation in STAT5B is associated with treatment-resistant severe atopic dermatitis. Clin Exp Allergy. 2022 07; 52(7):907-910. PMID: 35426955.
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    27. Tasli NP, G?nen ZB, Kirbas OK, G?kdemir NS, Bozkurt BT, Bayrakci B, Sagra? D, Taskan E, Demir S, Ekimci G?rcan N, Bayindir Bilgi? M, Bayrak ?F, Yetiskin H, Kaplan B, Pavel STI, Din? G, Serhatli M, ?akirca G, Eken A, Aslan V, Yay M, Karakukcu M, Unal E, G?l F, Basaran KE, Ozkul Y, Sahin F, Jones OY, Tekin S, ?zdarendeli A, Cetin M. Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2. Front Immunol. 2022; 13:824378. PMID: 35401544.
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    28. Alsavaf MB, Verboon JM, Dogan ME, Azizoglu ZB, Okus FZ, Ozcan A, Dundar M, Eken A, Donmez-Altuntas H, Sankaran VG, Unal E. A novel missense mutation outside the DNAJ domain of DNAJC21 is associated with Shwachman-Diamond syndrome. Br J Haematol. 2022 06; 197(6):e88-e93. PMID: 35298850.
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    29. Zehra Okus F, Busra Azizoglu Z, Canatan H, Eken A. S1P analogues SEW2871, BAF312 and FTY720 affect human Th17 and Treg generation ex vivo. Int Immunopharmacol. 2022 Jun; 107:108665. PMID: 35255303.
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    30. Yasar PA, K?se M, Erdem S, Hang?l M, Karaman ZF, Eken A. Circulating fibrocyte level in children with cystic fibrosis. Pediatr Int. 2022 Jan; 64(1):e15058. PMID: 34779084.
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    31. Goktas S, Azizoglu ZB, Petersheim D, Erdogan M, Eke Gungor H, Bisgin A, Tug Bozdogan S, Eken A, Unal E, Klein C, Patiroglu T. A Novel Intronic Mutation Reduces HAX1 Level and is Associated With Severe Congenital Neutropenia. J Pediatr Hematol Oncol. 2022 01 01; 44(1):e62-e67. PMID: 33560082.
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    32. Kolukisa B, Baser D, Akcam B, Danielson J, Bilgic Eltan S, Haliloglu Y, Sefer AP, Babayeva R, Akgun G, Charbonnier LM, Schmitz-Abe K, Kendir Demirkol Y, Zhang Y, Gonzaga-Jauregui C, Jimenez Heredia R, Kasap N, Kiykim A, Ozek Yucel E, Gok V, Unal E, Pac Kisaarslan A, Nepesov S, Baysoy G, Onal Z, Yesil G, Celkan TT, Cokugras H, Camcioglu Y, Eken A, Boztug K, Lo B, Karakoc-Aydiner E, Su HC, Ozen A, Chatila TA, Baris S. Evolution and long-term outcomes of combined immunodeficiency due to CARMIL2 deficiency. Allergy. 2022 03; 77(3):1004-1019. PMID: 34287962.
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    33. G?nay N, Pinarbasi AS, Dogan ME, Yel S, Balaban AG, Dursun I, Eken A, Akg?n H, D?ndar M, Poyrazoglu MH. A rare cause of membranoproliferative patterns of injury in siblings with steroid-resistant nephrotic syndrome:?Answers. Pediatr Nephrol. 2021 12; 36(12):4029-4032. PMID: 34185135.
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    34. G?nay N, Pinarbasi AS, Dogan ME, Yel S, Balaban AG, Dursun I, Eken A, Akg?n H, D?ndar M, Poyrazoglu MH. A rare cause of membranoproliferative patterns of injury in siblings with steroid-resistant nephrotic syndrome: Questions. Pediatr Nephrol. 2021 12; 36(12):4027-4028. PMID: 34185134.
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    35. Eken A, Erdem S, Haliloglu Y, Zehra Okus F, Cakir M, Fatih Yetkin M, Akcakoyunlu M, Karayigit MO, Azizoglu ZB, Bicer A, Gur TN, Aslan K, Hora M, Oukka M, Altuntas HD, Ufuk Nalbantoglu O, Gundogdu A, Mirza M, Canatan H. Temporal overexpression of IL-22 and Reg3? differentially impacts the severity of experimental autoimmune encephalomyelitis. Immunology. 2021 09; 164(1):73-89. PMID: 33876425.
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    36. Yilmaz E, Kuehn HS, Odakir E, Niemela JE, Ozcan A, Eken A, Rohlfs M, Cansever M, Gok V, Aydin F, Karakukcu M, Hauck F, Klein C, Unal E, Rosenzweig SD, Patiroglu T. Common Variable Immunodeficiency, Autoimmune Hemolytic Anemia, and Pancytopenia Associated With a Defect in IKAROS. J Pediatr Hematol Oncol. 2021 04 01; 43(3):e351-e357. PMID: 33122583.
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    37. Ozkaya M, Baykan A, Cakir M, Vural C, Sunkak S, Unal E, Eken A. The number and activity of CD3+TCR Va7.2+CD161+ cells are increased in children with acute rheumatic fever. Int J Cardiol. 2021 06 15; 333:174-183. PMID: 33631279.
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    38. Avcilar H, Eken A. Could imiquimod (Aldara 5% cream) or other TLR7 agonists be used in the treatment of COVID-19? Med Hypotheses. 2020 Nov; 144:110202. PMID: 33254510.
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    39. Eken A, Cansever M, Okus FZ, Erdem S, Nain E, Azizoglu ZB, Haliloglu Y, Karakukcu M, Ozcan A, Devecioglu O, Aksu G, Arikan Ayyildiz Z, Topal E, Karakoc Aydiner E, Kiykim A, Metin A, Cipe F, Kaya A, Artac H, Reisli I, Guner SN, Uygun V, Karasu G, D?nmez Altuntas H, Canatan H, Oukka M, Ozen A, Chatila TA, Keles S, Baris S, Unal E, Patiroglu T. ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients. Allergy. 2020 04; 75(4):921-932. PMID: 31596517.
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    40. Eken A, Okus Z, Erdem S, Azizoglu ZB, Haliloglu Y, Bicer A, Gur TN, Yilmaz E, Karakukcu M, Altuntas HD, Canatan H. IL-15 negatively regulates curdlan-induced IL-23 production by human monocyte-derived dendritic cells and subsequent Th17 response. North Clin Istanb. 2019; 6(4):379-387. PMID: 31909384.
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    41. Eken A, Cansever M, Somekh I, Mizoguchi Y, Zietara N, Okus FZ, Erdem S, Canatan H, Akyol S, Ozcan A, Karakukcu M, Hollizeck S, Rohlfs M, Unal E, Klein C, Patiroglu T. Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells. J Clin Immunol. 2019 05; 39(4):391-400. PMID: 31025232.
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    42. Eken A, Yetkin MF, Vural A, Okus FZ, Erdem S, Azizoglu ZB, Haliloglu Y, Cakir M, Turkoglu EM, Kilic O, Kara I, D?nmez Altuntas H, Oukka M, Kutuk MS, Mirza M, Canatan H. Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells. Front Immunol. 2019; 10:217. PMID: 30828332.
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    43. Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ, Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M, Jackson SW, Cerosaletti K, Buckner JH, Rawlings DJ. The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets. Front Immunol. 2019; 10:44. PMID: 30740104.
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    44. Eken A, Duhen R, Singh AK, Fry M, Buckner JH, Kita M, Bettelli E, Oukka M. S1P1 deletion differentially affects TH17 and Regulatory T cells. Sci Rep. 2017 10 10; 7(1):12905. PMID: 29018225.
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    45. Singh AK, Eken A, Hagin D, Komal K, Bhise G, Shaji A, Arkatkar T, Jackson SW, Bettelli E, Torgerson TR, Oukka M. DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling. JCI Insight. 2017 10 05; 2(19). PMID: 28978795.
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    46. Allenspach EJ, Finn LS, Rendi MH, Eken A, Singh AK, Oukka M, Taylor SD, Altman MC, Fligner CL, Ochs HD, Rawlings DJ, Torgerson TR. Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity. J Allergy Clin Immunol. 2017 08; 140(2):616-619.e7. PMID: 28322850.
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    47. Singh AK, Eken A, Fry M, Bettelli E, Oukka M. DOCK8 regulates protective immunity by controlling the function and survival of ROR?t+ ILCs. Nat Commun. 2014 Aug 05; 5:4603. PMID: 25091235.
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    48. Eken A, Singh AK, Oukka M. Interleukin 23 in Crohn's disease. Inflamm Bowel Dis. 2014 Mar; 20(3):587-95. PMID: 24481050.
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    49. Eken A, Ortiz V, Wands JR. Ethanol inhibits antigen presentation by dendritic cells. Clin Vaccine Immunol. 2011 Jul; 18(7):1157-66. PMID: 21562114.
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    50. Feng D, Eken A, Ortiz V, Wands JR. Chronic alcohol-induced liver disease inhibits dendritic cell function. Liver Int. 2011 Aug; 31(7):950-63. PMID: 21733084.
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    51. Szabo G, Wands JR, Eken A, Osna NA, Weinman SA, Machida K, Joe Wang H. Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage. Alcohol Clin Exp Res. 2010 Oct; 34(10):1675-86. PMID: 20608905.
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