 Mucin-5B
"Mucin-5B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gel-forming mucin that is predominantly expressed by submucosal glands of airway tissues and the SUBLINGUAL GLAND. It is one of the principal components of high molecular weight salivary mucin.
| Descriptor ID |
D055257
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| MeSH Number(s) |
D12.644.848.750 D12.776.395.560.631.207 D12.776.850.850
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| Concept/Terms |
Mucin-5B- Mucin-5B
- Mucin 5B
- Mucin-5 Subtype B, Tracheobronchial
- Mucin 5 Subtype B, Tracheobronchial
- High Molecular Weight Salivary Mucin MG1
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Below are MeSH descriptors whose meaning is more general than "Mucin-5B".
Below are MeSH descriptors whose meaning is more specific than "Mucin-5B".
This graph shows the total number of publications written about "Mucin-5B" by people in this website by year, and whether "Mucin-5B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 3 | 0 | 3 | | 2013 | 6 | 0 | 6 | | 2014 | 0 | 2 | 2 | | 2015 | 3 | 4 | 7 | | 2016 | 5 | 2 | 7 | | 2017 | 3 | 0 | 3 | | 2018 | 7 | 2 | 9 | | 2019 | 2 | 5 | 7 | | 2020 | 2 | 2 | 4 | | 2021 | 2 | 2 | 4 | | 2022 | 1 | 6 | 7 | | 2023 | 1 | 2 | 3 | | 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Mucin-5B" by people in Profiles.
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Kurche JS, Cool CD, Blumhagen RZ, Dobrinskikh E, Heinz D, Herrera JA, Yang IV, Schwartz DA. MUC5B Idiopathic Pulmonary Fibrosis Risk Variant Promotes a Mucosecretory Phenotype and Loss of Small Airway Secretory Cells. Am J Respir Crit Care Med. 2024 Aug 15; 210(4):517-521.
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Jaramillo AM, Vladar EK, Holguin F, Dickey BF, Evans CM. Emerging cell and molecular targets for treating mucus hypersecretion in asthma. Allergol Int. 2024 Jul; 73(3):375-381.
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Moll M, Peljto AL, Kim JS, Xu H, Debban CL, Chen X, Menon A, Putman RK, Ghosh AJ, Saferali A, Nishino M, Hatabu H, Hobbs BD, Hecker J, McDermott G, Sparks JA, Wain LV, Allen RJ, Tobin MD, Raby BA, Chun S, Silverman EK, Zamora AC, Ortega VE, Garcia CK, Barr RG, Bleecker ER, Meyers DA, Kaner RJ, Rich SS, Manichaikul A, Rotter JI, Dupuis J, O'Connor GT, Fingerlin TE, Hunninghake GM, Schwartz DA, Cho MH. A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2023 10 01; 208(7):791-801.
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Ghosh AJ, Moll M, Hobbs BD, Cardwell J, Saferali A, Castaldi PJ, Cho MH, Silverman EK, Yang IV, Hersh CP. Variability in MUC5B Expression Is Dependent on Genotype and Endotype in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023 05 15; 207(10):1401-1404.
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Dobrinskikh E, Hennessy CE, Kurche JS, Kim E, Estrella AM, Cardwell J, Yang IV, Schwartz DA. Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis. Am J Respir Cell Mol Biol. 2023 01; 68(1):62-74.
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Borie R, Cardwell J, Konigsberg IR, Moore CM, Zhang W, Sasse SK, Gally F, Dobrinskikh E, Walts A, Powers J, Brancato J, Rojas M, Wolters PJ, Brown KK, Blackwell TS, Nakanishi T, Richards JB, Gerber AN, Fingerlin TE, Sachs N, Pulit SL, Zappala Z, Schwartz DA, Yang IV. Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of MUC5B and DSP in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 11 15; 206(10):1259-1270.
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Schwartz DA, Blumhagen RZ, Fingerlin TE. Evolution of the Gain-of-Function MUC5B Promoter Variant. Am J Respir Crit Care Med. 2022 11 15; 206(10):1189-1191.
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Kim JS, Manichaikul AW, Hoffman EA, Balte P, Anderson MR, Bernstein EJ, Madahar P, Oelsner EC, Kawut SM, Wysoczanski A, Laine AF, Adegunsoye A, Ma JZ, Taub MA, Mathias RA, Rich SS, Rotter JI, Noth I, Garcia CK, Barr RG, Podolanczuk AJ. MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study. Thorax. 2023 06; 78(6):566-573.
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Okamoto T, Dobrinskikh E, Hennessy CE, Liu N, Schwarz MI, Evans CM, Fontenot AP, Yang IV, Schwartz DA. Muc5b plays a role in the development of inflammation and fibrosis in hypersensitivity pneumonitis induced by Saccharopolyspora rectivirgula. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L329-L337.
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Singanayagam A, Footitt J, Marczynski M, Radicioni G, Cross MT, Finney LJ, Trujillo-Torralbo MB, Calderazzo M, Zhu J, Aniscenko J, Clarke TB, Molyneaux PL, Bartlett NW, Moffatt MF, Cookson WO, Wedzicha J, Evans CM, Boucher RC, Kesimer M, Lieleg O, Mallia P, Johnston SL. Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease. J Clin Invest. 2022 04 15; 132(8).
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