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Stephanie J Bryant

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin
Phone303/735-6714
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Boulder
    DepartmentCollege Engineering & App Sci

    TitleFaculty Fellow
    InstitutionUniversity of Colorado Boulder
    DepartmentCollege Engineering & App Sci


    Collapse Research 
    Collapse research activities and funding
    R21AR079154     (BRYANT, STEPHANIE J ;CALVE, SARAH)Apr 1, 2021 - Mar 31, 2024
    NIH
    Mapping protein dynamics and their origin at biomaterial surfaces in vivo
    Role: Principal Investigator
    R21EB029261     (BRYANT, STEPHANIE J)Jul 15, 2020 - Apr 30, 2022
    NIH
    The Role of C-Flip in Mediating Pro-Survival Macrophages in the Foreign Body Response
    Role: Principal Investigator
    R21AR077419     (BRYANT, STEPHANIE J)Apr 1, 2020 - Mar 31, 2022
    NIH
    Prostaglandin E2 receptor 2 (EP2) as a Target for Prevention of the Foreign Body Response
    Role: Principal Investigator
    F33AR074287     (BRYANT, STEPHANIE J)Sep 1, 2018 - Aug 31, 2019
    NIH
    The Origin and Function of Macrophages in the Foreign Body Response
    Role: Principal Investigator
    R21AR071550     (KAAR, JOEL)Mar 21, 2018 - Feb 28, 2021
    NIH
    Single-molecule resolution of DAMPs and their impact on the FBR
    Role: Co-Principal Investigator
    R21HD092109     (PAYNE, KARIN A)Dec 1, 2017 - Nov 30, 2020
    NIH
    Physeal cartilage tissue engineering using mesenchymal stem cells directed towards chondrogenesis
    Role: Co-Principal Investigator
    R21AR069791     (BRYANT, STEPHANIE J)Mar 6, 2017 - Feb 29, 2020
    NIH
    A Hydrogel Model for Interstitial Fluid Flow
    Role: Principal Investigator
    R33HD090696     (PAYNE, KARIN A)Mar 1, 2017 - Feb 28, 2022
    NIH
    Treatment of pediatric physeal injuries using a 3D printed biomimetic of growth plate cartilage
    Role: Co-Principal Investigator
    R21HD090696     (PAYNE, KARIN A)Mar 1, 2017 - Feb 28, 2019
    NIH
    Treatment of pediatric physeal injuries using a 3D printed biomimetic of growth plate cartilage
    Role: Co-Principal Investigator
    R01AR069060     (BRYANT, STEPHANIE J)Jul 25, 2016 - Mar 31, 2027
    NIH
    Mechanically Stiff Hydrogels for Osteochondral Tissue Engineering
    Role: Principal Investigator
    R01AR065441     (BRYANT, STEPHANIE J)Sep 12, 2013 - Aug 31, 2019
    NIH
    Personalizing Matrix Assisted Autologous Chondrocyte Implantation
    Role: Principal Investigator
    R21AR064436     (BRYANT, STEPHANIE J)Apr 1, 2013 - Mar 31, 2017
    NIH
    The Interplay between Macrophages and Differentiating MSCs in Cell-Laden Hydrogel
    Role: Principal Investigator
    R21AR062696     (BRYANT, STEPHANIE J)Sep 7, 2012 - Aug 31, 2015
    NIH
    Dynamically Responsive Bioreactors for Cartilage Regeneration
    Role: Principal Investigator
    R21AR062197     (BRYANT, STEPHANIE J)Sep 1, 2012 - Dec 31, 2015
    NIH
    A Platform to Study Tenocyte Mechanotransduction
    Role: Principal Investigator
    R21AR061011     (BRYANT, STEPHANIE J)Mar 1, 2011 - Feb 28, 2014
    NIH
    Engineering Bimodal Degrading Hydrogels
    Role: Principal Investigator
    R03DE019505     (BRYANT, STEPHANIE J)Mar 1, 2010 - Feb 28, 2013
    NIH
    Modulating the Host Response to Tissue Engineering Scaffolds
    Role: Principal Investigator
    K22DE016608     (BRYANT, STEPHANIE J)Sep 6, 2005 - May 31, 2011
    NIH
    Mechanical Stimulation of Cells in Photopolymerized Gels
    Role: Principal Investigator
    F32HL074619     (BRYANT, STEPHANIE J)Aug 11, 2003 - Aug 10, 2005
    NIH
    Novel Cell Scaffolds: Guiding Heart Muscle Tissue Growth
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schoonraad SA, Jaimes AA, Singh AJX, Croland KJ, Bryant SJ. Osteogenic effects of covalently tethered rhBMP-2 and rhBMP-9 in an MMP-sensitive PEG hydrogel nanocomposite. Acta Biomater. 2023 10 15; 170:53-67. PMID: 37634836.
      View in: PubMed
    2. Grey EL, McClendon J, Suresh J, Alper S, Janssen WJ, Bryant SJ. Thiol-Michael Addition Microparticles: Their Synthesis, Characterization, and Uptake by Macrophages. ACS Biomater Sci Eng. 2023 07 10; 9(7):4223-4240. PMID: 37379254.
      View in: PubMed
    3. Maples MM, Schneider MC, Bryant SJ. Impact of Inter- and Intra-Donor Variability by Age on the Gel-to-Tissue Transition in MMP-Sensitive PEG Hydrogels for Cartilage Regeneration. ACS Appl Bio Mater. 2023 07 17; 6(7):2677-2689. PMID: 37367934.
      View in: PubMed
    4. Yu Y, Fischenich KM, Schoonraad SA, Weatherford S, Uzcategui AC, Eckstein K, Muralidharan A, Crespo-Cuevas V, Rodriguez-Fontan F, Killgore JP, Li G, McLeod RR, Miller NH, Ferguson VL, Bryant SJ, Payne KA. A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model. NPJ Regen Med. 2022 Oct 19; 7(1):60. PMID: 36261516.
      View in: PubMed
    5. Wilmoth RL, Sharma S, Ferguson VL, Bryant SJ. The effects of prostaglandin E2 on gene expression of IDG-SW3-derived osteocytes in 2D and 3D culture. Biochem Biophys Res Commun. 2022 11 19; 630:8-15. PMID: 36126467.
      View in: PubMed
    6. Muralidharan A, Crespo-Cuevas V, Ferguson VL, McLeod RR, Bryant SJ. Effects of Kinetic Chain Length on the Degradation of Poly(?-amino ester)-Based Networks and Use in 3D Printing by Projection Microstereolithography. Biomacromolecules. 2022 08 08; 23(8):3272-3285. PMID: 35793134.
      View in: PubMed
    7. Barthold JE, McCreery KP, Martinez J, Bellerjeau C, Ding Y, Bryant SJ, Whiting GL, Neu CP. Particulate ECM biomaterial ink is 3D printed and naturally crosslinked to form structurally-layered and lubricated cartilage tissue mimics. Biofabrication. 2022 03 16; 14(2). PMID: 35203071.
      View in: PubMed
    8. Saleh LS, Amer LD, Thompson BJ, Danhorn T, Knapp JR, Gibbings SL, Thomas S, Barthel L, O'Connor BP, Janssen WJ, Alper S, Bryant SJ. Mapping Macrophage Polarization and Origin during the Progression of the Foreign Body Response to a Poly(ethylene glycol) Hydrogel Implant. Adv Healthc Mater. 2022 05; 11(9):e2102209. PMID: 34967497.
      View in: PubMed
    9. Muralidharan A, McLeod RR, Bryant SJ. Hydrolytically degradable Poly (?-amino ester) resins with tunable degradation for 3D printing by projection micro-stereolithography. Adv Funct Mater. 2022 Feb 02; 32(6). PMID: 35813039.
      View in: PubMed
    10. Schoonraad SA, Fischenich KM, Eckstein KN, Crespo-Cuevas V, Savard LM, Muralidharan A, Tomaschke AA, Uzcategui AC, Randolph MA, McLeod RR, Ferguson VL, Bryant SJ. Biomimetic and mechanically supportive 3D printed scaffolds for cartilage and osteochondral tissue engineering using photopolymers and digital light processing. Biofabrication. 2021 09 16; 13(4). PMID: 34479218.
      View in: PubMed
    11. Vernerey FJ, Lalitha Sridhar S, Muralidharan A, Bryant SJ. Mechanics of 3D Cell-Hydrogel Interactions: Experiments, Models, and Mechanisms. Chem Rev. 2021 09 22; 121(18):11085-11148. PMID: 34473466.
      View in: PubMed
    12. Richardson BM, Walker CJ, Maples MM, Randolph MA, Bryant SJ, Anseth KS. Mechanobiological Interactions between Dynamic Compressive Loading and Viscoelasticity on Chondrocytes in Hydrazone Covalent Adaptable Networks for Cartilage Tissue Engineering. Adv Healthc Mater. 2021 05; 10(9):e2002030. PMID: 33738966.
      View in: PubMed
    13. Anderson AJ, Grey E, Bongiardina NJ, Bowman CN, Bryant SJ. Synthesis and Characterization of Click Nucleic Acid Conjugated Polymeric Microparticles for DNA Delivery Applications. Biomacromolecules. 2021 03 08; 22(3):1127-1136. PMID: 33621070.
      View in: PubMed
    14. Schoonraad SA, Trombold ML, Bryant SJ. The Effects of Stably Tethered BMP-2 on MC3T3-E1 Preosteoblasts Encapsulated in a PEG Hydrogel. Biomacromolecules. 2021 03 08; 22(3):1065-1079. PMID: 33555180.
      View in: PubMed
    15. Uzcategui AC, Higgins CI, Hergert JE, Tomaschke AE, Crespo-Cuevas V, Ferguson VL, Bryant SJ, McLeod RR, Killgore JP. Microscale Photopatterning of Through-thickness Modulus in a Monolithic and Functionally Graded 3D Printed Part. Small Sci. 2021 Mar; 1(3). PMID: 34458889.
      View in: PubMed
    16. Anderson AJ, Culver HR, Prieto TR, Martinez PJ, Sinha J, Bryant SJ, Bowman CN. Messenger RNA enrichment using synthetic oligo(T) click nucleic acids. Chem Commun (Camb). 2020 Nov 21; 56(90):13987-13990. PMID: 33094748.
      View in: PubMed
    17. Wilmoth RL, Ferguson VL, Bryant SJ. A 3D, Dynamically Loaded Hydrogel Model of the Osteochondral Unit to Study Osteocyte Mechanobiology. Adv Healthc Mater. 2020 11; 9(22):e2001226. PMID: 33073541.
      View in: PubMed
    18. Richardson BM, Walker CJ, Macdougall LJ, Hoye JW, Randolph MA, Bryant SJ, Anseth KS. Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation. Biomater Sci. 2020 Jul 21; 8(14):3804-3811. PMID: 32602512.
      View in: PubMed
    19. Schneider MC, Lalitha Sridhar S, Vernerey FJ, Bryant SJ. Spatiotemporal neocartilage growth in matrix-metalloproteinase-sensitive poly(ethylene glycol) hydrogels under dynamic compressive loading: an experimental and computational approach. J Mater Chem B. 2020 04 08; 8(14):2775-2791. PMID: 32155233.
      View in: PubMed
    20. Chu S, Maples MM, Bryant SJ. Cell encapsulation spatially alters crosslink density of poly(ethylene glycol) hydrogels formed from free-radical polymerizations. Acta Biomater. 2020 06; 109:37-50. PMID: 32268243.
      View in: PubMed
    21. Higgins CI, Killgore JP, DelRio FW, Bryant SJ, McLeod RR. Photo-tunable hydrogel mechanical heterogeneity informed by predictive transport kinetics model. Soft Matter. 2020 May 07; 16(17):4131-4141. PMID: 32202291.
      View in: PubMed
    22. Anderson AJ, Culver HR, Bryant SJ, Bowman CN. Viscoelastic and Thermoreversible Networks Crosslinked by Non-covalent Interactions Between "Clickable" Nucleic Acids Oligomers and DNA. Polym Chem. 2020 May 07; 11(17):2959-2968. PMID: 34992679.
      View in: PubMed
    23. Aziz AH, Wilmoth RL, Ferguson VL, Bryant SJ. IDG-SW3 Osteocyte Differentiation and Bone Extracellular Matrix Deposition Are Enhanced in a 3D Matrix Metalloproteinase-Sensitive Hydrogel. ACS Appl Bio Mater. 2020 Mar 16; 3(3):1666-1680. PMID: 32719827.
      View in: PubMed
    24. Saleh LS, Vanderheyden C, Frederickson A, Bryant SJ. Prostaglandin E2 and Its Receptor EP2 Modulate Macrophage Activation and Fusion in Vitro. ACS Biomater Sci Eng. 2020 05 11; 6(5):2668-2681. PMID: 33463295.
      View in: PubMed
    25. Ding Y, Johnson R, Sharma S, Ding X, Bryant SJ, Tan W. Tethering transforming growth factor ?1 to soft hydrogels guides vascular smooth muscle commitment from human mesenchymal stem cells. Acta Biomater. 2020 03 15; 105:68-77. PMID: 31982589.
      View in: PubMed
    26. Aisenbrey EA, Bilousova G, Payne K, Bryant SJ. Dynamic mechanical loading and growth factors influence chondrogenesis of induced pluripotent mesenchymal progenitor cells in a cartilage-mimetic hydrogel. Biomater Sci. 2019 Nov 19; 7(12):5388-5403. PMID: 31626251.
      View in: PubMed
    27. Faul?n Marruecos D, Saleh LS, Kim HH, Bryant SJ, Schwartz DK, Kaar JL. Stabilization of Fibronectin by Random Copolymer Brushes Inhibits Macrophage Activation. ACS Appl Bio Mater. 2019 Nov 18; 2(11):4698-4702. PMID: 35021468.
      View in: PubMed
    28. Yu Y, Rodriguez-Fontan F, Eckstein K, Muralidharan A, Uzcategui AC, Fuchs JR, Weatherford S, Erickson CB, Bryant SJ, Ferguson VL, Hadley Miller N, Li G, Payne KA. Rabbit Model of Physeal Injury for the Evaluation of Regenerative Medicine Approaches. Tissue Eng Part C Methods. 2019 12; 25(12):701-710. PMID: 31552802.
      View in: PubMed
    29. Amer LD, Saleh LS, Walker C, Thomas S, Janssen WJ, Alper S, Bryant SJ. Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels. Acta Biomater. 2019 12; 100:105-117. PMID: 31568879.
      View in: PubMed
    30. Muralidharan A, Uzcategui AC, McLeod RR, Bryant SJ. Stereolithographic 3D Printing for Deterministic Control over Integration in Dual-Material Composites. Adv Mater Technol. 2019 Nov; 4(11). PMID: 33043126.
      View in: PubMed
    31. Aisenbrey EA, Tomaschke AA, Schoonraad SA, Fischenich KM, Wahlquist JA, Randolph MA, Ferguson VL, Bryant SJ. Assessment and prevention of cartilage degeneration surrounding a focal chondral defect in the porcine model. Biochem Biophys Res Commun. 2019 06 30; 514(3):940-945. PMID: 31088681.
      View in: PubMed
    32. Aziz AH, Eckstein K, Ferguson VL, Bryant SJ. The effects of dynamic compressive loading on human mesenchymal stem cell osteogenesis in the stiff layer of a bilayer hydrogel. J Tissue Eng Regen Med. 2019 06; 13(6):946-959. PMID: 30793536.
      View in: PubMed
    33. Schneider MC, Chu S, Randolph MA, Bryant SJ. An in vitro and in vivo comparison of cartilage growth in chondrocyte-laden matrix metalloproteinase-sensitive poly(ethylene glycol) hydrogels with localized transforming growth factor ?3. Acta Biomater. 2019 07 15; 93:97-110. PMID: 30914256.
      View in: PubMed
    34. Aziz AH, Bryant SJ. A comparison of human mesenchymal stem cell osteogenesis in poly(ethylene glycol) hydrogels as a function of MMP-sensitive crosslinker and crosslink density in chemically defined medium. Biotechnol Bioeng. 2019 06; 116(6):1523-1536. PMID: 30776309.
      View in: PubMed
    35. Pascual-Garrido C, Aisenbrey EA, Rodriguez-Fontan F, Payne KA, Bryant SJ, Goodrich LR. Photopolymerizable Injectable Cartilage Mimetic Hydrogel for the Treatment of Focal Chondral Lesions: A Proof of Concept Study in a Rabbit Animal Model. Am J Sports Med. 2019 01; 47(1):212-221. PMID: 30481048.
      View in: PubMed
    36. Aisenbrey EA, Bryant SJ. The role of chondroitin sulfate in regulating hypertrophy during MSC chondrogenesis in a cartilage mimetic hydrogel under dynamic loading. Biomaterials. 2019 01; 190-191:51-62. PMID: 30391802.
      View in: PubMed
    37. Uzcategui AC, Muralidharan A, Ferguson VL, Bryant SJ, McLeod RR. Understanding and Improving Mechanical Properties in 3D printed Parts Using a Dual-Cure Acrylate-Based Resin for Stereolithography. Adv Eng Mater. 2018 Dec; 20(12). PMID: 30766445.
      View in: PubMed
    38. Saleh LS, Bryant SJ. In Vitro and In Vivo Models for Assessing the Host Response to Biomaterials. Drug Discov Today Dis Models. 2017; 24:13-21. PMID: 30479632.
      View in: PubMed
    39. Ding Y, Xu X, Sharma S, Floren M, Stenmark K, Bryant SJ, Neu CP, Tan W. Biomimetic soft fibrous hydrogels for contractile and pharmacologically responsive smooth muscle. Acta Biomater. 2018 07 01; 74:121-130. PMID: 29753912.
      View in: PubMed
    40. Jansen LE, Amer LD, Chen EY, Nguyen TV, Saleh LS, Emrick T, Liu WF, Bryant SJ, Peyton SR. Zwitterionic PEG-PC Hydrogels Modulate the Foreign Body Response in a Modulus-Dependent Manner. Biomacromolecules. 2018 07 09; 19(7):2880-2888. PMID: 29698603.
      View in: PubMed
    41. Anderson AJ, Peters EB, Neumann A, Wagner J, Fairbanks B, Bryant SJ, Bowman CN. Cytocompatibility and Cellular Internalization of PEGylated "Clickable" Nucleic Acid Oligomers. Biomacromolecules. 2018 07 09; 19(7):2535-2541. PMID: 29698604.
      View in: PubMed
    42. Carles-Carner M, Saleh LS, Bryant SJ. The effects of hydroxyapatite nanoparticles embedded in a MMP-sensitive photoclickable PEG hydrogel on encapsulated MC3T3-E1 pre-osteoblasts. Biomed Mater. 2018 05 02; 13(4):045009. PMID: 29611815.
      View in: PubMed
    43. Aisenbrey EA, Bryant SJ. A MMP7-sensitive photoclickable biomimetic hydrogel for MSC encapsulation towards engineering human cartilage. J Biomed Mater Res A. 2018 08; 106(8):2344-2355. PMID: 29577606.
      View in: PubMed
    44. Patel D, Sharma S, Screen HRC, Bryant SJ. Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel. Biochem Biophys Res Commun. 2018 05 15; 499(3):642-647. PMID: 29601813.
      View in: PubMed
    45. Saleh LS, Bryant SJ. The Host Response in Tissue Engineering: Crosstalk Between Immune cells and Cell-laden Scaffolds. Curr Opin Biomed Eng. 2018 Jun; 6:58-65. PMID: 30374467.
      View in: PubMed
    46. Saleh LS, Carles-Carner M, Bryant SJ. The in vitro effects of macrophages on the osteogenic capabilities of MC3T3-E1 cells encapsulated in a biomimetic poly(ethylene glycol) hydrogel. Acta Biomater. 2018 04 15; 71:37-48. PMID: 29505890.
      View in: PubMed
    47. Aisenbrey EA, Tomaschke A, Kleinjan E, Muralidharan A, Pascual-Garrido C, McLeod RR, Ferguson VL, Bryant SJ. A Stereolithography-Based 3D Printed Hybrid Scaffold for In Situ Cartilage Defect Repair. Macromol Biosci. 2018 02; 18(2). PMID: 29266791.
      View in: PubMed
    48. Pascual-Garrido C, Rodriguez-Fontan F, Aisenbrey EA, Payne KA, Chahla J, Goodrich LR, Bryant SJ. Current and novel injectable hydrogels to treat focal chondral lesions: Properties and applicability. J Orthop Res. 2018 01; 36(1):64-75. PMID: 28975658.
      View in: PubMed
    49. Wahlquist JA, DelRio FW, Randolph MA, Aziz AH, Heveran CM, Bryant SJ, Neu CP, Ferguson VL. Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage. Acta Biomater. 2017 12; 64:41-49. PMID: 29037894.
      View in: PubMed
    50. Bryant SJ, Vernerey FJ. Programmable Hydrogels for Cell Encapsulation and Neo-Tissue Growth to Enable Personalized Tissue Engineering. Adv Healthc Mater. 2018 01; 7(1). PMID: 28975716.
      View in: PubMed
    51. Shaw N, Erickson C, Bryant SJ, Ferguson VL, Krebs MD, Hadley-Miller N, Payne KA. Regenerative Medicine Approaches for the Treatment of Pediatric Physeal Injuries. Tissue Eng Part B Rev. 2018 04; 24(2):85-97. PMID: 28830302.
      View in: PubMed
    52. Sharma S, Floren M, Ding Y, Stenmark KR, Tan W, Bryant SJ. A photoclickable peptide microarray platform for facile and rapid screening of 3-D tissue microenvironments. Biomaterials. 2017 Oct; 143:17-28. PMID: 28756193.
      View in: PubMed
    53. Lalitha Sridhar S, Schneider MC, Chu S, de Roucy G, Bryant SJ, Vernerey FJ. Heterogeneity is key to hydrogel-based cartilage tissue regeneration. Soft Matter. 2017 Jul 19; 13(28):4841-4855. PMID: 28613313.
      View in: PubMed
    54. Schneider MC, Chu S, Sridhar SL, de Roucy G, Vernerey FJ, Bryant SJ. Local Heterogeneities Improve Matrix Connectivity in Degradable and Photoclickable Poly(ethylene glycol) Hydrogels for Applications in Tissue Engineering. ACS Biomater Sci Eng. 2017 Oct 09; 3(10):2480-2492. PMID: 29732400.
      View in: PubMed
    55. Chu S, Sridhar SL, Akalp U, Skaalure SC, Vernerey FJ, Bryant SJ. * Understanding the Spatiotemporal Degradation Behavior of Aggrecanase-Sensitive Poly(ethylene glycol) Hydrogels for Use in Cartilage Tissue Engineering. Tissue Eng Part A. 2017 08; 23(15-16):795-810. PMID: 28351221.
      View in: PubMed
    56. Schneider MC, Barnes CA, Bryant SJ. Characterization of the chondrocyte secretome in photoclickable poly(ethylene glycol) hydrogels. Biotechnol Bioeng. 2017 09; 114(9):2096-2108. PMID: 28436002.
      View in: PubMed
    57. Akalp U, Schnatwinkel C, Stoykovich MP, Bryant SJ, Vernerey FJ. Structural Modeling of Mechanosensitivity in Non-Muscle Cells: Multiscale Approach to Understand Cell Sensing. ACS Biomater Sci Eng. 2017; 3(11):2934-2942. PMID: 29202009.
      View in: PubMed
    58. Patel D, Sharma S, Bryant SJ, Screen HR. Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response. Adv Healthc Mater. 2017 Feb; 6(4). PMID: 28026126.
      View in: PubMed
    59. Fiedler CI, Aisenbrey EA, Wahlquist JA, Heveran CM, Ferguson VL, Bryant SJ, McLeod RR. Enhanced mechanical properties of photo-clickable thiol-ene PEG hydrogels through repeated photopolymerization of in-swollen macromer. Soft Matter. 2016 Nov 09; 12(44):9095-9104. PMID: 27774538.
      View in: PubMed
    60. Aziz AH, Wahlquist J, Sollner A, Ferguson V, DelRio FW, Bryant SJ. Mechanical characterization of sequentially layered photo-clickable thiol-ene hydrogels. J Mech Behav Biomed Mater. 2017 01; 65:454-465. PMID: 27664813.
      View in: PubMed
    61. Akalp U, Bryant SJ, Vernerey FJ. Tuning tissue growth with scaffold degradation in enzyme-sensitive hydrogels: a mathematical model. Soft Matter. 2016 Sep 28; 12(36):7505-20. PMID: 27548744.
      View in: PubMed
    62. Neumann AJ, Quinn T, Bryant SJ. Nondestructive evaluation of a new hydrolytically degradable and photo-clickable PEG hydrogel for cartilage tissue engineering. Acta Biomater. 2016 07 15; 39:1-11. PMID: 27180026.
      View in: PubMed
    63. Amer LD, Bryant SJ. The In Vitro and In Vivo Response to MMP-Sensitive Poly(Ethylene Glycol) Hydrogels. Ann Biomed Eng. 2016 06; 44(6):1959-69. PMID: 27080375.
      View in: PubMed
    64. Aisenbrey EA, Bryant SJ. Mechanical loading inhibits hypertrophy in chondrogenically differentiating hMSCs within a biomimetic hydrogel. J Mater Chem B. 2016 May 28; 4(20):3562-3574. PMID: 27499854.
      View in: PubMed
    65. Skaalure SC, Akalp U, Vernerey FJ, Bryant SJ. Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels. Adv Healthc Mater. 2016 Feb 18; 5(4):432-8. PMID: 26781187.
      View in: PubMed
    66. Akalp U, Chu S, Skaalure SC, Bryant SJ, Doostan A, Vernerey FJ. Determination of the Polymer-Solvent Interaction Parameter for PEG Hydrogels in Water: Application of a Self Learning Algorithm. Polymer (Guildf). 2015 Jun 01; 66:135-147. PMID: 25999615.
      View in: PubMed
    67. Kinneberg KR, Nelson A, Stender ME, Aziz AH, Mozdzen LC, Harley BA, Bryant SJ, Ferguson VL. Reinforcement of Mono- and Bi-layer Poly(Ethylene Glycol) Hydrogels with a Fibrous Collagen Scaffold. Ann Biomed Eng. 2015 Nov; 43(11):2618-29. PMID: 26001970.
      View in: PubMed
    68. Amer LD, Holtzinger A, Keller G, Mahoney MJ, Bryant SJ. Enzymatically degradable poly(ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates. Acta Biomater. 2015 Aug; 22:103-10. PMID: 25913222.
      View in: PubMed
    69. Steinmetz NJ, Aisenbrey EA, Westbrook KK, Qi HJ, Bryant SJ. Mechanical loading regulates human MSC differentiation in a multi-layer hydrogel for osteochondral tissue engineering. Acta Biomater. 2015 Jul; 21:142-53. PMID: 25900444.
      View in: PubMed
    70. Swartzlander MD, Blakney AK, Amer LD, Hankenson KD, Kyriakides TR, Bryant SJ. Immunomodulation by mesenchymal stem cells combats the foreign body response to cell-laden synthetic hydrogels. Biomaterials. 2015 Feb; 41:79-88. PMID: 25522967.
      View in: PubMed
    71. Swartzlander MD, Barnes CA, Blakney AK, Kaar JL, Kyriakides TR, Bryant SJ. Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics. Biomaterials. 2015 Feb; 41:26-36. PMID: 25522962.
      View in: PubMed
    72. Skaalure SC, Chu S, Bryant SJ. An enzyme-sensitive PEG hydrogel based on aggrecan catabolism for cartilage tissue engineering. Adv Healthc Mater. 2015 Feb 18; 4(3):420-31. PMID: 25296398.
      View in: PubMed
    73. Sircar S, Aisenbrey E, Bryant SJ, Bortz DM. Determining equilibrium osmolarity in poly(ethylene glycol)/chondrotin sulfate gels mimicking articular cartilage. J Theor Biol. 2015 Jan 07; 364:397-406. PMID: 25300942.
      View in: PubMed
    74. Skaalure SC, Radhakrishnan SM, Bryant SJ. Physiological osmolarities do not enhance long-term tissue synthesis in chondrocyte-laden degradable poly(ethylene glycol) hydrogels. J Biomed Mater Res A. 2015 Jun; 103(6):2186-92. PMID: 25205522.
      View in: PubMed
    75. Farnsworth NL, Mead BE, Antunez LR, Palmer AE, Bryant SJ. Ionic osmolytes and intracellular calcium regulate tissue production in chondrocytes cultured in a 3D charged hydrogel. Matrix Biol. 2014 Nov; 40:17-26. PMID: 25128592.
      View in: PubMed
    76. Skaalure SC, Dimson SO, Pennington AM, Bryant SJ. Semi-interpenetrating networks of hyaluronic acid in degradable PEG hydrogels for cartilage tissue engineering. Acta Biomater. 2014 Aug; 10(8):3409-20. PMID: 24769116.
      View in: PubMed
    77. Amer LD, Mahoney MJ, Bryant SJ. Tissue engineering approaches to cell-based type 1 diabetes therapy. Tissue Eng Part B Rev. 2014 Oct; 20(5):455-67. PMID: 24417705.
      View in: PubMed
    78. Roberts JJ, Elder RM, Neumann AJ, Jayaraman A, Bryant SJ. Interaction of hyaluronan binding peptides with glycosaminoglycans in poly(ethylene glycol) hydrogels. Biomacromolecules. 2014 Apr 14; 15(4):1132-41. PMID: 24597474.
      View in: PubMed
    79. Roberts JJ, Bryant SJ. Comparison of photopolymerizable thiol-ene PEG and acrylate-based PEG hydrogels for cartilage development. Biomaterials. 2013 Dec; 34(38):9969-79. PMID: 24060418.
      View in: PubMed
    80. Linnenberger A, Bodine MI, Fiedler C, Roberts JJ, Skaalure SC, Quinn JP, Bryant SJ, Cole M, McLeod RR. Three dimensional live cell lithography. Opt Express. 2013 Apr 22; 21(8):10269-77. PMID: 23609736.
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    81. Farnsworth NL, Antunez LR, Bryant SJ. Dynamic compressive loading differentially regulates chondrocyte anabolic and catabolic activity with age. Biotechnol Bioeng. 2013 Jul; 110(7):2046-57. PMID: 23404228.
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    82. Swartzlander MD, Lynn AD, Blakney AK, Kyriakides TR, Bryant SJ. Understanding the host response to cell-laden poly(ethylene glycol)-based hydrogels. Biomaterials. 2013 Jan; 34(4):952-64. PMID: 23149012.
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    83. Dhote V, Skaalure S, Akalp U, Roberts J, Bryant SJ, Vernerey FJ. On the role of hydrogel structure and degradation in controlling the transport of cell-secreted matrix molecules for engineered cartilage. J Mech Behav Biomed Mater. 2013 Mar; 19:61-74. PMID: 23276516.
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    84. Farnsworth NL, Antunez LR, Bryant SJ. Influence of chondrocyte maturation on acute response to impact injury in PEG hydrogels. J Biomech. 2012 Oct 11; 45(15):2556-63. PMID: 22964019.
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    85. Farnsworth N, Bensard C, Bryant SJ. The role of the PCM in reducing oxidative stress induced by radical initiated photoencapsulation of chondrocytes in poly(ethylene glycol) hydrogels. Osteoarthritis Cartilage. 2012 Nov; 20(11):1326-35. PMID: 22796510.
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    86. Steinmetz NJ, Bryant SJ. Chondroitin sulfate and dynamic loading alter chondrogenesis of human MSCs in PEG hydrogels. Biotechnol Bioeng. 2012 Oct; 109(10):2671-82. PMID: 22511184.
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    87. Skaalure SC, Milligan IL, Bryant SJ. Age impacts extracellular matrix metabolism in chondrocytes encapsulated in degradable hydrogels. Biomed Mater. 2012 Apr; 7(2):024111. PMID: 22456004.
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    88. Blakney AK, Swartzlander MD, Bryant SJ. The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels. J Biomed Mater Res A. 2012 Jun; 100(6):1375-86. PMID: 22407522.
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    89. Hume SL, Hoyt SM, Walker JS, Sridhar BV, Ashley JF, Bowman CN, Bryant SJ. Alignment of multi-layered muscle cells within three-dimensional hydrogel macrochannels. Acta Biomater. 2012 Jul; 8(6):2193-202. PMID: 22326973.
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    90. Wingate K, Bonani W, Tan Y, Bryant SJ, Tan W. Compressive elasticity of three-dimensional nanofiber matrix directs mesenchymal stem cell differentiation to vascular cells with endothelial or smooth muscle cell markers. Acta Biomater. 2012 Apr; 8(4):1440-9. PMID: 22266031.
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    91. Roberts JJ, Nicodemus GD, Greenwald EC, Bryant SJ. Degradation improves tissue formation in (un)loaded chondrocyte-laden hydrogels. Clin Orthop Relat Res. 2011 Oct; 469(10):2725-34. PMID: 21347817.
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    92. Vernerey FJ, Greenwald EC, Bryant SJ. Triphasic mixture model of cell-mediated enzymatic degradation of hydrogels. Comput Methods Biomech Biomed Engin. 2012; 15(11):1197-210. PMID: 21809945.
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    93. Roberts JJ, Earnshaw A, Ferguson VL, Bryant SJ. Comparative study of the viscoelastic mechanical behavior of agarose and poly(ethylene glycol) hydrogels. J Biomed Mater Res B Appl Biomater. 2011 Oct; 99(1):158-69. PMID: 21714081.
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    94. Steinmetz NJ, Bryant SJ. The effects of intermittent dynamic loading on chondrogenic and osteogenic differentiation of human marrow stromal cells encapsulated in RGD-modified poly(ethylene glycol) hydrogels. Acta Biomater. 2011 Nov; 7(11):3829-40. PMID: 21742067.
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    95. Roberts JJ, Nicodemus GD, Giunta S, Bryant SJ. Incorporation of biomimetic matrix molecules in PEG hydrogels enhances matrix deposition and reduces load-induced loss of chondrocyte-secreted matrix. J Biomed Mater Res A. 2011 Jun 01; 97(3):281-91. PMID: 21442729.
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    96. Lynn AD, Blakney AK, Kyriakides TR, Bryant SJ. Temporal progression of the host response to implanted poly(ethylene glycol)-based hydrogels. J Biomed Mater Res A. 2011 Mar 15; 96(4):621-31. PMID: 21268236.
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    97. Klouda L, Perkins KR, Watson BM, Hacker MC, Bryant SJ, Raphael RM, Kasper FK, Mikos AG. Thermoresponsive, in situ cross-linkable hydrogels based on N-isopropylacrylamide: fabrication, characterization and mesenchymal stem cell encapsulation. Acta Biomater. 2011 Apr; 7(4):1460-7. PMID: 21187170.
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    98. Lanasa SM, Hoffecker IT, Bryant SJ. Presence of pores and hydrogel composition influence tensile properties of scaffolds fabricated from well-defined sphere templates. J Biomed Mater Res B Appl Biomater. 2011 Feb; 96(2):294-302. PMID: 21210509.
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    99. Nicodemus GD, Skaalure SC, Bryant SJ. Gel structure has an impact on pericellular and extracellular matrix deposition, which subsequently alters metabolic activities in chondrocyte-laden PEG hydrogels. Acta Biomater. 2011 Feb; 7(2):492-504. PMID: 20804868.
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    100. Lynn AD, Bryant SJ. Phenotypic changes in bone marrow-derived murine macrophages cultured on PEG-based hydrogels activated or not by lipopolysaccharide. Acta Biomater. 2011 Jan; 7(1):123-32. PMID: 20674808.
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    101. Lynn AD, Kyriakides TR, Bryant SJ. Characterization of the in vitro macrophage response and in vivo host response to poly(ethylene glycol)-based hydrogels. J Biomed Mater Res A. 2010 Jun 01; 93(3):941-53. PMID: 19708075.
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    102. Villanueva I, Bishop NL, Bryant SJ. Medium osmolarity and pericellular matrix development improves chondrocyte survival when photoencapsulated in poly(ethylene glycol) hydrogels at low densities. Tissue Eng Part A. 2009 Oct; 15(10):3037-48. PMID: 19331581.
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    103. Nicodemus GD, Bryant SJ. Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels. Osteoarthritis Cartilage. 2010 Jan; 18(1):126-37. PMID: 19748607.
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    104. Liang X, Lynn AD, King DM, Bryant SJ, Weimer AW. Biocompatible interface films deposited within porous polymers by Atomic Layer Deposition (ALD). ACS Appl Mater Interfaces. 2009 Sep; 1(9):1988-95. PMID: 20355824.
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    105. Villanueva I, Gladem SK, Kessler J, Bryant SJ. Dynamic loading stimulates chondrocyte biosynthesis when encapsulated in charged hydrogels prepared from poly(ethylene glycol) and chondroitin sulfate. Matrix Biol. 2010 Jan; 29(1):51-62. PMID: 19720146.
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    106. Villanueva I, Weigel CA, Bryant SJ. Cell-matrix interactions and dynamic mechanical loading influence chondrocyte gene expression and bioactivity in PEG-RGD hydrogels. Acta Biomater. 2009 Oct; 5(8):2832-46. PMID: 19508905.
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    107. LaNasa SM, Bryant SJ. Influence of ECM proteins and their analogs on cells cultured on 2-D hydrogels for cardiac muscle tissue engineering. Acta Biomater. 2009 Oct; 5(8):2929-38. PMID: 19457460.
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    108. Villanueva I, Klement BJ, von Deutsch D, Bryant SJ. Cross-linking density alters early metabolic activities in chondrocytes encapsulated in poly(ethylene glycol) hydrogels and cultured in the rotating wall vessel. Biotechnol Bioeng. 2009 Mar 01; 102(4):1242-50. PMID: 18949761.
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    109. Nicodemus GD, Shiplet KA, Kaltz SR, Bryant SJ. Dynamic compressive loading influences degradation behavior of PEG-PLA hydrogels. Biotechnol Bioeng. 2009 Feb 15; 102(3):948-59. PMID: 18831003.
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    110. Atzet S, Curtin S, Trinh P, Bryant S, Ratner B. Degradable poly(2-hydroxyethyl methacrylate)-co-polycaprolactone hydrogels for tissue engineering scaffolds. Biomacromolecules. 2008 Dec; 9(12):3370-7. PMID: 19061434.
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    111. Nicodemus GD, Bryant SJ. Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Eng Part B Rev. 2008 Jun; 14(2):149-65. PMID: 18498217.
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    112. Bryant SJ, Nicodemus GD, Villanueva I. Designing 3D photopolymer hydrogels to regulate biomechanical cues and tissue growth for cartilage tissue engineering. Pharm Res. 2008 Oct; 25(10):2379-86. PMID: 18509600.
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    113. Nicodemus GD, Bryant SJ. The role of hydrogel structure and dynamic loading on chondrocyte gene expression and matrix formation. J Biomech. 2008; 41(7):1528-36. PMID: 18417139.
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    114. Villanueva I, Hauschulz DS, Mejic D, Bryant SJ. Static and dynamic compressive strains influence nitric oxide production and chondrocyte bioactivity when encapsulated in PEG hydrogels of different crosslinking densities. Osteoarthritis Cartilage. 2008 Aug; 16(8):909-18. PMID: 18203631.
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    115. Nicodemus GD, Villanueva I, Bryant SJ. Mechanical stimulation of TMJ condylar chondrocytes encapsulated in PEG hydrogels. J Biomed Mater Res A. 2007 Nov; 83(2):323-31. PMID: 17437304.
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    116. Bryant SJ, Cuy JL, Hauch KD, Ratner BD. Photo-patterning of porous hydrogels for tissue engineering. Biomaterials. 2007 Jul; 28(19):2978-86. PMID: 17397918.
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    117. Bryant SJ, Arthur JA, Anseth KS. Incorporation of tissue-specific molecules alters chondrocyte metabolism and gene expression in photocrosslinked hydrogels. Acta Biomater. 2005 Mar; 1(2):243-52. PMID: 16701801.
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    118. Bryant SJ, Anseth KS, Lee DA, Bader DL. Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res. 2004 Sep; 22(5):1143-9. PMID: 15304291.
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    119. Bryant SJ, Bender RJ, Durand KL, Anseth KS. Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production. Biotechnol Bioeng. 2004 Jun 30; 86(7):747-55. PMID: 15162450.
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    120. Bryant SJ, Chowdhury TT, Lee DA, Bader DL, Anseth KS. Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng. 2004 Mar; 32(3):407-17. PMID: 15095815.
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    121. Ratner BD, Bryant SJ. Biomaterials: where we have been and where we are going. Annu Rev Biomed Eng. 2004; 6:41-75. PMID: 15255762.
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    122. Bryant SJ, Durand KL, Anseth KS. Manipulations in hydrogel chemistry control photoencapsulated chondrocyte behavior and their extracellular matrix production. J Biomed Mater Res A. 2003 Dec 15; 67(4):1430-6. PMID: 14624532.
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    123. Martens PJ, Bryant SJ, Anseth KS. Tailoring the degradation of hydrogels formed from multivinyl poly(ethylene glycol) and poly(vinyl alcohol) macromers for cartilage tissue engineering. Biomacromolecules. 2003 Mar-Apr; 4(2):283-92. PMID: 12625723.
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    124. Bryant SJ, Anseth KS. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J Biomed Mater Res A. 2003 Jan 01; 64(1):70-9. PMID: 12483698.
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    125. Anseth KS, Metters AT, Bryant SJ, Martens PJ, Elisseeff JH, Bowman CN. In situ forming degradable networks and their application in tissue engineering and drug delivery. J Control Release. 2002 Jan 17; 78(1-3):199-209. PMID: 11772461.
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    126. Bryant SJ, Anseth KS. Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels. J Biomed Mater Res. 2002 Jan; 59(1):63-72. PMID: 11745538.
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    127. Bryant SJ, Nuttelman CR, Anseth KS. Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro. J Biomater Sci Polym Ed. 2000; 11(5):439-57. PMID: 10896041.
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    128. Bryant SJ, Nuttelman CR, Anseth KS. The effects of crosslinking density on cartilage formation in photocrosslinkable hydrogels. Biomed Sci Instrum. 1999; 35:309-14. PMID: 11143369.
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