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Ryan Karn Bachtell

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentPsych-Psychology
Phone303/735-1012
    Other Positions
    TitleAssoc Chair
    InstitutionUniversity of Colorado Boulder
    DepartmentPsych-Psychology

    TitleFaculty Fellow
    InstitutionUniversity of Colorado Boulder
    DepartmentPsych-Psychology


    Collapse Research 
    Collapse research activities and funding
    U01DA051937     (EHRINGER, MARISSA A)Aug 1, 2020 - May 31, 2025
    NIH
    Identification of genes and genetic networks contributing to opioid use disorder traits in the Hybrid Rat Diversity Panel
    Role: Co-Principal Investigator
    R21DA045952     (SADDORIS, MICHAEL)Feb 15, 2019 - Jan 31, 2021
    NIH
    Monitoring real-time adenosine release in the NAc with fast-scan cyclic voltammetry
    Role: Co-Principal Investigator
    R01DA033358     (BACHTELL, RYAN K)Jan 1, 2013 - Aug 31, 2019
    NIH
    Adenosine Receptor Involvement in Methamphetamine Reward and Relapse
    Role: Principal Investigator
    R03DA029240     (BACHTELL, RYAN K.)Mar 15, 2011 - Feb 28, 2013
    NIH
    Effects of Adenosine Signaling on Cocaine Reward and Relapse
    Role: Principal Investigator
    F32DA018481     (BACHTELL, RYAN K.)Sep 1, 2004 - Aug 31, 2007
    NIH
    Dopamine receptor interactions with GluR1 in addiction
    Role: Principal Investigator
    F31AA013223     (BACHTELL, RYAN K.)Jun 22, 2001
    NIH
    Characterizing the Edinger-Westphal response to alcohol
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Duffy EP, Bachtell RK, Ehringer MA. Opioid trail: Tracking contributions to opioid use disorder from host genetics to the gut microbiome. Neurosci Biobehav Rev. 2024 Jan; 156:105487. PMID: 38040073.
      View in: PubMed
    2. Parise LF, I?iguez SD, Warren BL, Parise EM, Bachtell RK, Dietz D, Nestler EJ, Bola?os-Guzm?n CA. Viral-mediated expression of Erk2 in the nucleus accumbens regulates responses to rewarding and aversive stimuli. bioRxiv. 2023 Oct 03. PMID: 37873069.
      View in: PubMed
    3. Brown KT, Levis SC, O'Neill CE, Levy C, Rice KC, Watkins LR, Bachtell RK. Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking. Psychopharmacology (Berl). 2023 Jul; 240(7):1587-1600. PMID: 37286899.
      View in: PubMed
    4. Bachtell RK, Larson TA, Winkler MC. Adenosine receptor stimulation inhibits methamphetamine-associated cue seeking. J Psychopharmacol. 2023 02; 37(2):192-203. PMID: 36629009.
      View in: PubMed
    5. Wang X, Northcutt AL, Cochran TA, Zhang X, Fabisiak TJ, Haas ME, Amat J, Li H, Rice KC, Maier SF, Bachtell RK, Hutchinson MR, Watkins LR. Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell. ACS Chem Neurosci. 2019 08 21; 10(8):3622-3634. PMID: 31282647.
      View in: PubMed
    6. Arnold MR, Williams PH, McArthur JA, Archuleta AR, O'Neill CE, Hassell JE, Smith DG, Bachtell RK, Lowry CA. Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems. Neuropharmacology. 2019 04; 148:257-271. PMID: 30579884.
      View in: PubMed
    7. Brown KT, Bachtell RK. Activation of the Immune System During a Developmental Window May Provide a Link Between Early Life Stress and Future Susceptibility to Cocaine Abuse. Biol Psychiatry. 2018 12 15; 84(12):865-866. PMID: 30466507.
      View in: PubMed
    8. Larson TA, O'Neill CE, Palumbo MP, Bachtell RK. Effects of adolescent caffeine consumption on cocaine self-administration and reinstatement of cocaine seeking. J Psychopharmacol. 2018 Nov 28; 269881118812098. PMID: 30484365.
      View in: PubMed
    9. Larson TA, Winkler MC, Stafford J, Levis SC, O'Neill CE, Bachtell RK. Role of dopamine D2-like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking. Psychopharmacology (Berl). 2019 Apr; 236(4):1207-1218. PMID: 30470862.
      View in: PubMed
    10. Haynes NS, O'Neill CE, Hobson BD, Bachtell RK. Effects of adenosine A2A receptor antagonists on cocaine-induced locomotion and cocaine seeking. Psychopharmacology (Berl). 2019 Feb; 236(2):699-708. PMID: 30392131.
      View in: PubMed
    11. Bachtell RK, Jones JD, Heinzerling KG, Beardsley PM, Comer SD. Glial and neuroinflammatory targets for treating substance use disorders. Drug Alcohol Depend. 2017 11 01; 180:156-170. PMID: 28892721.
      View in: PubMed
    12. Brown KT, Levis SC, O'Neill CE, Northcutt AL, Fabisiak TJ, Watkins LR, Bachtell RK. Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking. Brain Behav Immun. 2018 Jan; 67:130-138. PMID: 28813640.
      View in: PubMed
    13. Winkler MC, Greager EM, Stafford J, Bachtell RK. Methamphetamine self-administration reduces alcohol consumption and preference in alcohol-preferring P rats. Addict Biol. 2018 01; 23(1):90-101. PMID: 27860181.
      View in: PubMed
    14. Klipec WD, Burrow KR, O'Neill C, Cao JL, Lawyer CR, Ostertag E, Fowler M, Bachtell RK, Illig KR, Cooper DC. Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards. Behav Brain Res. 2016 06 01; 306:117-27. PMID: 26988269.
      View in: PubMed
    15. O'Neill CE, Newsom RJ, Stafford J, Scott T, Archuleta S, Levis SC, Spencer RL, Campeau S, Bachtell RK. Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. Psychoneuroendocrinology. 2016 May; 67:40-50. PMID: 26874560.
      View in: PubMed
    16. Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, Yin H, Zahniser NR, Katz JL, Rice KC, Maier SF, Bachtell RK, Watkins LR. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Mol Psychiatry. 2015 Dec; 20(12):1525-37. PMID: 25644383.
      View in: PubMed
    17. Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4. CNS Neurol Disord Drug Targets. 2015; 14(6):692-9. PMID: 26022268.
      View in: PubMed
    18. O'Neill CE, Levis SC, Schreiner DC, Amat J, Maier SF, Bachtell RK. Effects of adolescent caffeine consumption on cocaine sensitivity. Neuropsychopharmacology. 2015 Mar; 40(4):813-21. PMID: 25328052.
      View in: PubMed
    19. Kavanagh KA, Schreiner DC, Levis SC, O'Neill CE, Bachtell RK. Role of adenosine receptor subtypes in methamphetamine reward and reinforcement. Neuropharmacology. 2015 Feb; 89:265-73. PMID: 25301277.
      View in: PubMed
    20. O'Neill CE, Hobson BD, Levis SC, Bachtell RK. Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A1 and A 2A receptors during extinction training in rats. Psychopharmacology (Berl). 2014 Aug; 231(16):3179-88. PMID: 24562064.
      View in: PubMed
    21. Merritt KE, Bachtell RK. Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. PLoS One. 2013; 8(11):e78258. PMID: 24223783.
      View in: PubMed
    22. Hobson BD, O'Neill CE, Levis SC, Monteggia LM, Neve RL, Self DW, Bachtell RK. Adenosine A1 and dopamine d1 receptor regulation of AMPA receptor phosphorylation and cocaine-seeking behavior. Neuropsychopharmacology. 2013 Sep; 38(10):1974-83. PMID: 23598433.
      View in: PubMed
    23. Rasmus KC, O'Neill CE, Bachtell RK, Cooper DC. Cocaine self-administration in rats lacking a functional trpc4 gene. F1000Res. 2013; 2:110. PMID: 24555056.
      View in: PubMed
    24. Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, Maslanik T, Chapman TR, Strand KA, Fleshner M, Bachtell RK, Somogyi AA, Yin H, Katz JL, Rice KC, Maier SF, Watkins LR. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. J Neurosci. 2012 Aug 15; 32(33):11187-200. PMID: 22895704.
      View in: PubMed
    25. Hobson BD, Merritt KE, Bachtell RK. Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats. Neuropharmacology. 2012 Nov; 63(6):1172-81. PMID: 22749927.
      View in: PubMed
    26. O'Neill CE, LeTendre ML, Bachtell RK. Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. Neuropsychopharmacology. 2012 Apr; 37(5):1245-56. PMID: 22169945.
      View in: PubMed
    27. Edwards S, Bachtell RK, Guzman D, Whisler KN, Self DW. Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration. Addict Biol. 2011 Jul; 16(3):450-7. PMID: 21309958.
      View in: PubMed
    28. Cadle BA, Rasmus KC, Varela JA, Leverich LS, O'Neill CE, Bachtell RK, Cooper DC. Cellular phone-based image acquisition and quantitative ratiometric method for detecting cocaine and benzoylecgonine for biological and forensic applications. Subst Abuse. 2010; 4:21-33. PMID: 22879741.
      View in: PubMed
    29. Bachtell RK, Self DW. Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2009 Oct; 206(3):469-78. PMID: 19641899.
      View in: PubMed
    30. Bachtell RK, Self DW. Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior. J Neurosci. 2008 Nov 26; 28(48):12808-14. PMID: 19036973.
      View in: PubMed
    31. Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Gent LM, Berton O, Bolanos CA, DiLeone RJ, Parada LF, Nestler EJ, Self DW. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry. 2009 Apr 15; 65(8):696-701. PMID: 18990365.
      View in: PubMed
    32. Winstanley CA, Bachtell RK, Theobald DE, Laali S, Green TA, Kumar A, Chakravarty S, Self DW, Nestler EJ. Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex. Cereb Cortex. 2009 Feb; 19(2):435-44. PMID: 18539927.
      View in: PubMed
    33. Perrotti LI, Weaver RR, Robison B, Renthal W, Maze I, Yazdani S, Elmore RG, Knapp DJ, Selley DE, Martin BR, Sim-Selley L, Bachtell RK, Self DW, Nestler EJ. Distinct patterns of DeltaFosB induction in brain by drugs of abuse. Synapse. 2008 May; 62(5):358-69. PMID: 18293355.
      View in: PubMed
    34. Bachtell RK, Choi KH, Simmons DL, Falcon E, Monteggia LM, Neve RL, Self DW. Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior. Eur J Neurosci. 2008 May; 27(9):2229-40. PMID: 18430032.
      View in: PubMed
    35. Winstanley CA, LaPlant Q, Theobald DE, Green TA, Bachtell RK, Perrotti LI, DiLeone RJ, Russo SJ, Garth WJ, Self DW, Nestler EJ. DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci. 2007 Sep 26; 27(39):10497-507. PMID: 17898221.
      View in: PubMed
    36. Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, Self DW. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat Neurosci. 2007 Aug; 10(8):1029-37. PMID: 17618281.
      View in: PubMed
    37. Edwards S, Graham DL, Bachtell RK, Self DW. Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. Eur J Neurosci. 2007 Apr; 25(7):2201-13. PMID: 17439498.
      View in: PubMed
    38. Bachtell RK, Whisler K, Karanian D, Self DW. Effects of intra-nucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat. Psychopharmacology (Berl). 2005 Nov; 183(1):41-53. PMID: 16163523.
      View in: PubMed
    39. Bachtell RK, Weitemier AZ, Ryabinin AE. Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption. Eur J Neurosci. 2004 Sep; 20(6):1613-23. PMID: 15355328.
      View in: PubMed
    40. Bachtell RK, Weitemier AZ, Galvan-Rosas A, Tsivkovskaia NO, Risinger FO, Phillips TJ, Grahame NJ, Ryabinin AE. The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. J Neurosci. 2003 Mar 15; 23(6):2477-87. PMID: 12657708.
      View in: PubMed
    41. Kiianmaa K, Hyyti? P, Samson HH, Engel JA, Svensson L, S?derpalm B, Larsson A, Colombo G, Vacca G, Finn DA, Bachtell RK, Ryabinin AE. New neuronal networks involved in ethanol reinforcement. Alcohol Clin Exp Res. 2003 Feb; 27(2):209-19. PMID: 12605070.
      View in: PubMed
    42. Bachtell RK, Tsivkovskaia NO, Ryabinin AE. Identification of temperature-sensitive neural circuits in mice using c-Fos expression mapping. Brain Res. 2003 Jan 17; 960(1-2):157-64. PMID: 12505668.
      View in: PubMed
    43. Bachtell RK, Tsivkovskaia NO, Ryabinin AE. Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms. J Pharmacol Exp Ther. 2002 Aug; 302(2):516-24. PMID: 12130710.
      View in: PubMed
    44. Bachtell RK, Tsivkovskaia NO, Ryabinin AE. Strain differences in urocortin expression in the Edinger-Westphal nucleus and its relation to alcohol-induced hypothermia. Neuroscience. 2002; 113(2):421-34. PMID: 12127099.
      View in: PubMed
    45. Ryabinin AE, Bachtell RK, Freeman P, Risinger FO. ITF expression in mouse brain during acquisition of alcohol self-administration. Brain Res. 2001 Jan 26; 890(1):192-5. PMID: 11164784.
      View in: PubMed
    46. Bachtell RK, Ryabinin AE. Interactive effects of nicotine and alcohol co-administration on expression of inducible transcription factors in mouse brain. Neuroscience. 2001; 103(4):941-54. PMID: 11301203.
      View in: PubMed
    47. Ryabinin AE, Wang YM, Bachtell RK, Kinney AE, Grubb MC, Mark GP. Cocaine- and alcohol-mediated expression of inducible transcription factors is blocked by pentobarbital anesthesia. Brain Res. 2000 Sep 22; 877(2):251-61. PMID: 10986339.
      View in: PubMed
    48. Bachtell RK, Wang YM, Freeman P, Risinger FO, Ryabinin AE. Alcohol drinking produces brain region-selective changes in expression of inducible transcription factors. Brain Res. 1999 Nov 20; 847(2):157-65. PMID: 10575084.
      View in: PubMed
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