 Fibrinogens, Abnormal
"Fibrinogens, Abnormal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.
| Descriptor ID |
D015241
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| MeSH Number(s) |
D12.776.124.050.250.265 D12.776.124.125.500.265 D23.119.490.265
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fibrinogens, Abnormal".
Below are MeSH descriptors whose meaning is more specific than "Fibrinogens, Abnormal".
This graph shows the total number of publications written about "Fibrinogens, Abnormal" by people in this website by year, and whether "Fibrinogens, Abnormal" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fibrinogens, Abnormal" by people in Profiles.
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Walton BL, Getz TM, Bergmeier W, Lin FC, Uitte de Willige S, Wolberg AS. The fibrinogen ?A/?' isoform does not promote acute arterial thrombosis in mice. J Thromb Haemost. 2014 May; 12(5):680-9.
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Smyk-Pearson S, Golden-Mason L, Klarquist J, Burton JR, Tester IA, Wang CC, Culbertson N, Vandenbark AA, Rosen HR. Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection. J Infect Dis. 2008 Jan 01; 197(1):46-57.
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Walter S, Stabler S, Lefkowitz JB. Fibrinogen Denver: a dysfibrinogenemia associated with an abnormal Reptilase time and significant bleeding. Haemophilia. 2006 Jul; 12(4):393-7.
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