 Diazepam
"Diazepam" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
| Descriptor ID |
D003975
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| MeSH Number(s) |
D03.633.100.079.080.070.216
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| Concept/Terms |
Diazepam- Diazepam
- 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
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Below are MeSH descriptors whose meaning is more general than "Diazepam".
Below are MeSH descriptors whose meaning is more specific than "Diazepam".
This graph shows the total number of publications written about "Diazepam" by people in this website by year, and whether "Diazepam" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2014 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Diazepam" by people in Profiles.
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Nakhaee S, Farrokhfall K, Miri-Moghaddam E, Askari M, Amirabadizadeh A, Foadoddini M, Mehrpour O. Effects of naloxone and diazepam on blood glucose levels in tramadol overdose using generalized estimating equation (GEE) model; (an experimental study). BMC Endocr Disord. 2021 Sep 06; 21(1):180.
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Nakhaee S, Farrokhfall K, Miri-Moghaddam E, Foadoddini M, Askari M, Amirabadizadeh A, Brent J, Megarbane B, Mehrpour O. The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study. Behav Brain Funct. 2021 May 29; 17(1):5.
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Brodnik ZD, Batra A, Oleson EB, Espa?a RA. Local GABAA Receptor-Mediated Suppression of Dopamine Release within the Nucleus Accumbens. ACS Chem Neurosci. 2019 04 17; 10(4):1978-1985.
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Schelp SA, Brodnik ZD, Rakowski DR, Pultorak KJ, Sambells AT, Espa?a RA, Oleson EB. Diazepam Concurrently Increases the Frequency and Decreases the Amplitude of Transient Dopamine Release Events in the Nucleus Accumbens. J Pharmacol Exp Ther. 2018 01; 364(1):145-155.
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Meyers ML, Mirsky DM, Dannull KA, Tong S, Crombleholme TM. Effects of Maternal Valium Administration on Fetal MRI Motion Artifact: A Comparison Study at High Altitude. Fetal Diagn Ther. 2017; 42(2):124-129.
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Stamenic TT, Poe MM, Rehman S, Santrac A, Divovic B, Scholze P, Ernst M, Cook JM, Savic MM. Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the a5 subunit. Eur J Pharmacol. 2016 Nov 15; 791:433-443.
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Pobbe RL, Lopes MA, Vasconcelos AT, Yamashita PS, de Bortoli VC, Zangrossi H. Influence of procedural variables on rat inhibitory avoidance and escape behaviors generated by the elevated T-maze. Behav Brain Res. 2014 Oct 15; 273:45-51.
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Chamberlain JM, Okada P, Holsti M, Mahajan P, Brown KM, Vance C, Gonzalez V, Lichenstein R, Stanley R, Brousseau DC, Grubenhoff J, Zemek R, Johnson DW, Clemons TE, Baren J. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. JAMA. 2014 Apr 23-30; 311(16):1652-60.
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Kovacevic J, Timic T, Tiruveedhula VV, Batinic B, Namjoshi OA, Milic M, Joksimovic S, Cook JM, Savic MM. Duration of treatment and activation of a1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats. Brain Res Bull. 2014 May; 104:1-6.
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Obradovic ALj, Joksimovic S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinic B, Radulovic T, Markovic B, Roth BL, Sieghart W, Cook JM, Savic MM. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. Brain Res. 2014 Mar 20; 1554:36-48.
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