 Serotonin
"Serotonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
| Descriptor ID |
D012701
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| MeSH Number(s) |
D02.092.211.215.801.852 D03.633.100.473.914.814 D23.469.050.650
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| Concept/Terms |
Serotonin- Serotonin
- 5-Hydroxytryptamine
- 5 Hydroxytryptamine
- Hippophaine
- 3-(2-Aminoethyl)-1H-indol-5-ol
- Enteramine
- 5-HT
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Below are MeSH descriptors whose meaning is more general than "Serotonin".
Below are MeSH descriptors whose meaning is more specific than "Serotonin".
This graph shows the total number of publications written about "Serotonin" by people in this website by year, and whether "Serotonin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 2 | 2 | 4 | | 1998 | 2 | 0 | 2 | | 1999 | 1 | 1 | 2 | | 2000 | 2 | 0 | 2 | | 2001 | 2 | 1 | 3 | | 2002 | 3 | 2 | 5 | | 2003 | 5 | 4 | 9 | | 2004 | 6 | 6 | 12 | | 2005 | 11 | 5 | 16 | | 2006 | 5 | 8 | 13 | | 2007 | 4 | 2 | 6 | | 2008 | 5 | 7 | 12 | | 2009 | 4 | 6 | 10 | | 2010 | 5 | 3 | 8 | | 2011 | 6 | 6 | 12 | | 2012 | 3 | 6 | 9 | | 2013 | 5 | 3 | 8 | | 2014 | 5 | 4 | 9 | | 2015 | 6 | 4 | 10 | | 2016 | 2 | 3 | 5 | | 2017 | 5 | 7 | 12 | | 2018 | 1 | 2 | 3 | | 2019 | 3 | 3 | 6 | | 2020 | 2 | 5 | 7 | | 2021 | 1 | 2 | 3 | | 2022 | 1 | 2 | 3 | | 2023 | 1 | 0 | 1 | | 2024 | 4 | 2 | 6 | | 2025 | 2 | 1 | 3 |
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Below are the most recent publications written about "Serotonin" by people in Profiles.
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Payet JM, Baratta MV, Christianson JP, Lowry CA, Hale MW. Modulation of dorsal raphe nucleus connectivity and serotonergic signalling to the insular cortex in the prosocial effects of chronic fluoxetine. Neuropharmacology. 2025 Jul 01; 272:110406.
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Scholl JL, Rogers JT, Feng N, Forster GL, Watt MJ, Yaeger JDW, Buchanan MW, Lowry CA, Renner KJ. Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic cation transporter 3 (OCT3). Stress. 2025 Dec; 28(1):2457765.
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Elad A, Moalem B, Sender D, Bardugo A, Kim KS, Arad Y, Benhayon H, Gal Etzyoni A, Greenstein N, Halfon A, Knapp S, Malis M, Peck B, Samuel I, Kupietzky A, Daher S, Forkosh E, Hakimian D, Hershcovici T, Ilani N, Katz L, Rottenstreich M, Vainer E, Ishay Y, Zlotnick E, Nasereddin A, Shiff I, Benson A, Grinbaum R, Mishra S, Kotler S, Samuelson LC, Sandoval DA, Ben-Haroush Schyr R, Ben-Zvi D. Sleeve gastrectomy reveals the plasticity of the human gastric epithelium. Nat Commun. 2025 Jan 20; 16(1):869.
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Romanowicz J, Niemiec S, Khailova L, Lehmann T, Mancuso CA, Mitchell MB, Morgan GJ, Twite M, DiMaria MV, Klawitter J, Davidson JA, Frank BS. Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease. Physiol Rep. 2024 Nov; 12(22):e70133.
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Ferraz-Bannitz R, Ozturk B, Cummings C, Efthymiou V, Casanova Querol P, Poulos L, Wang H, Navarrete V, Saeed H, Mulla CM, Pan H, Dreyfuss JM, Simonson DC, Sandoval DA, Patti ME. Postprandial metabolomics analysis reveals disordered serotonin metabolism in post-bariatric hypoglycemia. J Clin Invest. 2024 Sep 12; 134(21).
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Archambault JL, Hernandez TL, Nozik ES, Palmer C, Dillon M, Singh RJ, Galambos C, Delaney CA. Relationship between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn. J Pediatr. 2025 Jan; 276:114290.
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Chen HC, He P, McDonald M, Williamson MR, Varadharajan S, Lozzi B, Woo J, Choi DJ, Sardar D, Huang-Hobbs E, Sun H, Ippagunta SM, Jain A, Rao G, Merchant TE, Ellison DW, Noebels JL, Bertrand KC, Mack SC, Deneen B. Histone serotonylation regulates ependymoma tumorigenesis. Nature. 2024 Aug; 632(8026):903-910.
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Page CE, Epperson CN, Novick AM, Duffy KA, Thompson SM. Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder. Mol Psychiatry. 2024 Dec; 29(12):3802-3813.
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Ogelman R, Gomez Wulschner LE, Hoelscher VM, Hwang IW, Chang VN, Oh WC. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nat Commun. 2024 Feb 16; 15(1):1368.
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Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel BR, Maze I, Deneen B. Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. Science. 2023 06 16; 380(6650):eade0027.
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