 Motor Neuron Disease
"Motor Neuron Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Descriptor ID |
D016472
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| MeSH Number(s) |
C10.574.562 C10.668.467
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| Concept/Terms |
Motor Neuron Disease- Motor Neuron Disease
- Motor Neuron Diseases
- Neuron Disease, Motor
- Neuron Diseases, Motor
- Motor System Disease
- Motor System Diseases
Lateral Sclerosis- Lateral Sclerosis
- Lateral Scleroses
- Scleroses, Lateral
- Sclerosis, Lateral
- Primary Lateral Sclerosis
- Lateral Scleroses, Primary
- Lateral Sclerosis, Primary
- Primary Lateral Scleroses
- Scleroses, Primary Lateral
- Sclerosis, Primary Lateral
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Below are MeSH descriptors whose meaning is more general than "Motor Neuron Disease".
Below are MeSH descriptors whose meaning is more specific than "Motor Neuron Disease".
This graph shows the total number of publications written about "Motor Neuron Disease" by people in this website by year, and whether "Motor Neuron Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 1 | 2 | | 2012 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Motor Neuron Disease" by people in Profiles.
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Pourshafie N, Masati E, Lopez A, Bunker E, Snyder A, Edwards NA, Winkelsas AM, Fischbeck KH, Grunseich C. Altered SYNJ2BP-mediated mitochondrial-ER contacts in motor neuron disease. Neurobiol Dis. 2022 10 01; 172:105832.
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Kleinschmidt-DeMasters BK, Marshall CB, Cykowski MD. Paraneoplastic Lower Motor Neuron Disease. J Neuropathol Exp Neurol. 2021 12 29; 80(12):1125-1127.
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Kang X, Quan D. Electrodiagnostic Assessment of Motor Neuron Disease. Neurol Clin. 2021 11; 39(4):1071-1081.
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Paganoni S, De Marchi F, Chan J, Thrower SK, Staff NP, Datta N, Kisanuki YY, Drory V, Fournier C, Pioro EP, Goutman SA, Atassi N, Jeon M, Caldwell S, Mcdonough T, Gentile C, Liu J, Turner M, Denny C, Felice K, Green M, Scarberry S, Abu-Saleh S, Nefussy B, Hastings D, Kim S, Swihart B, Arcila-Londono X, Newman DS, Silverman M, Genge A, Salmon K, Elman L, Mccluskey L, Almasy K, Gotkine M, Goslin K, Cummings A, Edwards EK, Rivner M, Bouchard K, Quarles B, Kwan J, Jaffa M, Baloh R, Allred P, Walk D, Maiser S, Manousakis G, Ferment V, Fernandes JAM, Thaisetthawatkul P, Heimes D, Phillips M, Sams L, Kahler M, Corcoran A, Larriviere DG, Chotto S, Juba G. The NEALS primary lateral sclerosis registry. Amyotroph Lateral Scler Frontotemporal Degener. 2020 11; 21(sup1):74-81.
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Foster LA, Salajegheh MK. Motor Neuron Disease: Pathophysiology, Diagnosis, and Management. Am J Med. 2019 01; 132(1):32-37.
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Moon DK, Johnson AMF. Lower Extremity Problem-Solving: Challenging Cases. Phys Med Rehabil Clin N Am. 2018 08; 29(3):619-631.
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Black HA, Leighton DJ, Cleary EM, Rose E, Stephenson L, Colville S, Ross D, Warner J, Porteous M, Gorrie GH, Swingler R, Goldstein D, Harms MB, Connick P, Pal S, Aitman TJ, Chandran S. Genetic epidemiology of motor neuron disease-associated variants in the Scottish population. Neurobiol Aging. 2017 03; 51:178.e11-178.e20.
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Li Y, Dunphy JM, Pedraza CE, Lynch CR, Cardona SM, Macklin WB, Lynch WP. Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence. J Virol. 2016 Jan 13; 90(7):3385-99.
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Tsai J, Bert RJ, Gilden D. Zoster paresis: asymptomatic MRI lesions far beyond the site of rash and focal weakness. J Neurol Sci. 2013 Jul 15; 330(1-2):119-20.
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Pastula DM, Moore DH, Bedlack RS. Creatine for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev. 2012 Dec 12; 12:CD005225.
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