Muscular Atrophy, Spinal
"Muscular Atrophy, Spinal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
Descriptor ID |
D009134
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MeSH Number(s) |
C10.228.854.468 C10.574.562.500 C10.668.467.500
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Concept/Terms |
Muscular Atrophy, Spinal- Muscular Atrophy, Spinal
- Atrophy, Spinal Muscular
- Spinal Amyotrophy
- Amyotrophies, Spinal
- Amyotrophy, Spinal
- Spinal Amyotrophies
- Spinal Muscular Atrophy
Hereditary Motor Neuronopathy- Hereditary Motor Neuronopathy
- Hereditary Motor Neuronopathies
- Motor Neuronopathies, Hereditary
- Motor Neuronopathy, Hereditary
- Neuronopathies, Hereditary Motor
- Neuronopathy, Hereditary Motor
Scapuloperoneal Form of Spinal Muscular Atrophy- Scapuloperoneal Form of Spinal Muscular Atrophy
- Spinal Muscular Atrophy, Scapuloperoneal Form
- Spinal Muscular Atrophy, Scapuloperoneal
- Amyotrophy, Neurogenic Scapuloperoneal, New England Type
- Scapuloperoneal Spinal Muscular Atrophy
Progressive Muscular Atrophy- Progressive Muscular Atrophy
- Atrophies, Progressive Muscular
- Atrophy, Progressive Muscular
- Muscular Atrophies, Progressive
- Muscular Atrophy, Progressive
- Progressive Muscular Atrophies
- Progressive Myelopathic Muscular Atrophy
- Myelopathic Muscular Atrophy, Progressive
Bulbospinal Neuronopathy- Bulbospinal Neuronopathy
- Bulbospinal Neuronopathies
- Neuronopathies, Bulbospinal
- Neuronopathy, Bulbospinal
Myelopathic Muscular Atrophy- Myelopathic Muscular Atrophy
- Atrophy, Myelopathic Muscular
- Muscular Atrophy, Myelopathic
- Adult-Onset Spinal Muscular Atrophy
- Adult Onset Spinal Muscular Atrophy
- Muscular Atrophy, Adult Spinal
- Adult Spinal Muscular Atrophy
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Below are MeSH descriptors whose meaning is more general than "Muscular Atrophy, Spinal".
Below are MeSH descriptors whose meaning is more specific than "Muscular Atrophy, Spinal".
This graph shows the total number of publications written about "Muscular Atrophy, Spinal" by people in this website by year, and whether "Muscular Atrophy, Spinal" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1998 | 2 | 0 | 2 | 2015 | 2 | 0 | 2 | 2016 | 2 | 1 | 3 | 2017 | 1 | 0 | 1 | 2018 | 2 | 0 | 2 | 2020 | 2 | 0 | 2 | 2021 | 1 | 0 | 1 | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Muscular Atrophy, Spinal" by people in Profiles.
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Leon-Astudillo C, Okorie CUA, McCown MY, Dy FJ, Puranik S, Prero M, ElMallah MK, Treat L, Gross JE. ATS Core Curriculum 2022. Pediatric Pulmonary Medicine: Updates in pediatric neuromuscular disease. Pediatr Pulmonol. 2023 Jul; 58(7):1866-1874.
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Pourshafie N, Masati E, Lopez A, Bunker E, Snyder A, Edwards NA, Winkelsas AM, Fischbeck KH, Grunseich C. Altered SYNJ2BP-mediated mitochondrial-ER contacts in motor neuron disease. Neurobiol Dis. 2022 10 01; 172:105832.
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Kang X, Quan D. Electrodiagnostic Assessment of Motor Neuron Disease. Neurol Clin. 2021 11; 39(4):1071-1081.
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Moshe-Lilie O, Visser A, Chahin N, Ragole T, Dimitrova D, Karam C. Nusinersen in adult patients with spinal muscular atrophy: Observations from a single center. Neurology. 2020 07 28; 95(4):e413-e416.
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Pourshafie N, Masati E, Bunker E, Nickolls AR, Thepmankorn P, Johnson K, Feng X, Ekins T, Grunseich C, Fischbeck KH. Linking epigenetic dysregulation, mitochondrial impairment, and metabolic dysfunction in SBMA motor neurons. JCI Insight. 2020 07 09; 5(13).
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Weaver JJ, Hallam DK, Chick JFB, Vaidya S, Shin DS, Natarajan N, Rad N, Reis J, Koo KSH, Shivaram GM, Thibodeau A, Apkon S, Monroe EJ. Transforaminal intrathecal delivery of nusinersen for older children and adults with spinal muscular atrophy and complex spinal anatomy: an analysis of 200 consecutive injections. J Neurointerv Surg. 2021 Jan; 13(1):75-78.
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Martinez EE, Quinn N, Arouchon K, Anzaldi R, Tarrant S, Ma NS, Griffin J, Darras BT, Graham RJ, Mehta NM. Comprehensive nutritional and metabolic assessment in patients with spinal muscular atrophy: Opportunity for an individualized approach. Neuromuscul Disord. 2018 06; 28(6):512-519.
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Burgart AM, Magnus D, Tabor HK, Paquette ED, Frader J, Glover JJ, Jackson BM, Harrison CH, Urion DK, Graham RJ, Brandsema JF, Feudtner C. Ethical Challenges Confronted When Providing Nusinersen Treatment for Spinal Muscular Atrophy. JAMA Pediatr. 2018 Feb 01; 172(2):188-192.
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Weaver JJ, Natarajan N, Shaw DWW, Apkon SD, Koo KSH, Shivaram GM, Monroe EJ. Transforaminal intrathecal delivery of nusinersen using cone-beam computed tomography for children with spinal muscular atrophy and extensive surgical instrumentation: early results of technical success and safety. Pediatr Radiol. 2018 03; 48(3):392-397.
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Fleming J, Quan D. A case of congenital spinal muscular atrophy with pain due to a mutation in TRPV4. Neuromuscul Disord. 2016 Dec; 26(12):841-843.
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