 Methylmalonyl-CoA Mutase
"Methylmalonyl-CoA Mutase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. A block in this enzymatic conversion leads to the metabolic disease, methylmalonic aciduria. EC 5.4.99.2.
| Descriptor ID |
D008765
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| MeSH Number(s) |
D08.811.399.520.625
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| Concept/Terms |
Methylmalonyl-CoA Mutase- Methylmalonyl-CoA Mutase
- Methylmalonyl CoA Mutase
- Mutase, Methylmalonyl-CoA
- Methylmalonyl-CoA Isomerase
- Isomerase, Methylmalonyl-CoA
- Methylmalonyl CoA Isomerase
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Below are MeSH descriptors whose meaning is more general than "Methylmalonyl-CoA Mutase".
Below are MeSH descriptors whose meaning is more specific than "Methylmalonyl-CoA Mutase".
This graph shows the total number of publications written about "Methylmalonyl-CoA Mutase" by people in this website by year, and whether "Methylmalonyl-CoA Mutase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methylmalonyl-CoA Mutase" by people in Profiles.
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McDonald MK, Fritz JA, Jia D, Scheuchner D, Snyder FF, Stanislaus A, Curle J, Li L, Stabler SP, Allen RH, Mains PE, Gravel RA. Identification of ABC transporters acting in vitamin B12 metabolism in Caenorhabditis elegans. Mol Genet Metab. 2017 12; 122(4):160-171.
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Chandler RJ, Sloan J, Fu H, Tsai M, Stabler S, Allen R, Kaestner KH, Kazazian HH, Venditti CP. Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle. BMC Med Genet. 2007 Oct 15; 8:64.
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Chandler RJ, Aswani V, Tsai MS, Falk M, Wehrli N, Stabler S, Allen R, Sedensky M, Kazazian HH, Venditti CP. Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Mol Genet Metab. 2006 Sep-Oct; 89(1-2):64-73.
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Al-Owain M, Freehauf C, Bernstein L, Kappy M, Thomas J. Growth hormone deficiency associated with methylmalonic acidemia. J Pediatr Endocrinol Metab. 2004 Feb; 17(2):239-43.
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Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J. 1993 Nov; 7(14):1344-53.
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Kolhouse JF, Stabler SP, Allen RH. Identification and perturbation of mutant human fibroblasts based on measurements of methylmalonic acid and total homocysteine in the culture media. Arch Biochem Biophys. 1993 Jun; 303(2):355-60.
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Stabler SP, Brass EP, Marcell PD, Allen RH. Inhibition of cobalamin-dependent enzymes by cobalamin analogues in rats. J Clin Invest. 1991 Apr; 87(4):1422-30.
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Krahenbuhl S, Ray DB, Stabler SP, Allen RH, Brass EP. Increased hepatic mitochondrial capacity in rats with hydroxy-cobalamin[c-lactam]-induced methylmalonic aciduria. J Clin Invest. 1990 Dec; 86(6):2054-61.
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Kolhouse JF, Stabler SP, Allen RH. L-methylmalonyl-CoA mutase from human placenta. Methods Enzymol. 1988; 166:407-14.
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Fenton WA, Hack AM, Kraus JP, Rosenberg LE. Immunochemical studies of fibroblasts from patients with methylmalonyl-CoA mutase apoenzyme deficiency: detection of a mutation interfering with mitochondrial import. Proc Natl Acad Sci U S A. 1987 Mar; 84(5):1421-4.
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