 Methylmalonyl-CoA Decarboxylase
"Methylmalonyl-CoA Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carboxy-lyase that catalyzes the decarboxylation of (S)-2-Methyl-3-oxopropanoyl-CoA to propanoyl-CoA. In microorganisms the reaction can be coupled to the vectorial transport of SODIUM ions across the cytoplasmic membrane.
| Descriptor ID |
D043586
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| MeSH Number(s) |
D08.811.520.224.125.387
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| Concept/Terms |
Methylmalonyl-CoA Decarboxylase- Methylmalonyl-CoA Decarboxylase
- Decarboxylase, Methylmalonyl-CoA
- Methylmalonyl CoA Decarboxylase
- Propionyl-Coenzyme A Carboxylase
- Carboxylase, Propionyl-Coenzyme A
- Propionyl Coenzyme A Carboxylase
- Propionyl-CoA Carboxylase
- Propionyl CoA Carboxylase
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Below are MeSH descriptors whose meaning is more general than "Methylmalonyl-CoA Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Methylmalonyl-CoA Decarboxylase".
This graph shows the total number of publications written about "Methylmalonyl-CoA Decarboxylase" by people in this website by year, and whether "Methylmalonyl-CoA Decarboxylase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Methylmalonyl-CoA Decarboxylase" by people in Profiles.
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Collard R, Majtan T, Park I, Kraus JP. Import of TAT-Conjugated Propionyl Coenzyme A Carboxylase Using Models of Propionic Acidemia. Mol Cell Biol. 2018 03 15; 38(6).
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Guenzel AJ, Collard R, Kraus JP, Matern D, Barry MA. Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors. Hum Gene Ther. 2015 Mar; 26(3):153-60.
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Damavandi MD, Chan EC, Kraus JP, Ho PC, Kang TS. Development of an UPLC-MS/MS method for assaying the enzymatic activity of propionyl coenzyme-A carboxylase. Bioanalysis. 2014 Feb; 6(3):335-48.
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Guenzel AJ, Hofherr SE, Hillestad M, Barry M, Weaver E, Venezia S, Kraus JP, Matern D, Barry MA. Generation of a hypomorphic model of propionic acidemia amenable to gene therapy testing. Mol Ther. 2013 Jul; 21(7):1316-23.
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Jiang H, Rao KS, Yee VC, Kraus JP. Characterization of four variant forms of human propionyl-CoA carboxylase expressed in Escherichia coli. J Biol Chem. 2005 Jul 29; 280(30):27719-27.
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Chloupkov? M, Ravn K, Schwartz M, Kraus JP. Changes in the carboxyl terminus of the beta subunit of human propionyl-CoA carboxylase affect the oligomer assembly and catalysis: expression and characterization of seven patient-derived mutant forms of PCC in Escherichia coli. Mol Genet Metab. 2000 Dec; 71(4):623-32.
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Ravn K, Chloupkova M, Christensen E, Brandt NJ, Simonsen H, Kraus JP, Nielsen IM, Skovby F, Schwartz M. High incidence of propionic acidemia in greenland is due to a prevalent mutation, 1540insCCC, in the gene for the beta-subunit of propionyl CoA carboxylase. Am J Hum Genet. 2000 Jul; 67(1):203-6.
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Kelson TL, Ohura T, Kraus JP. Chaperonin-mediated assembly of wild-type and mutant subunits of human propionyl-CoA carboxylase expressed in Escherichia coli. Hum Mol Genet. 1996 Mar; 5(3):331-7.
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Tahara T, Kraus JP, Ohura T, Rosenberg LE, Fenton WA. Three independent mutations in the same exon of the PCCB gene: differences between Caucasian and Japanese propionic acidaemia. J Inherit Metab Dis. 1993; 16(2):353-60.
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Ohura T, Kraus JP, Rosenberg LE. Unequal synthesis and differential degradation of propionyl CoA carboxylase subunits in cells from normal and propionic acidemia patients. Am J Hum Genet. 1989 Jul; 45(1):33-40.
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