 Ornithine Decarboxylase
"Ornithine Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
| Descriptor ID |
D009955
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| MeSH Number(s) |
D08.811.520.224.125.425
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| Concept/Terms |
Ornithine Decarboxylase- Ornithine Decarboxylase
- Decarboxylase, Ornithine
- Ornithine Carboxy-lyase
- Carboxy-lyase, Ornithine
- Ornithine Carboxy lyase
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Below are MeSH descriptors whose meaning is more general than "Ornithine Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Ornithine Decarboxylase".
This graph shows the total number of publications written about "Ornithine Decarboxylase" by people in this website by year, and whether "Ornithine Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ornithine Decarboxylase" by people in Profiles.
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Banerjee B, Khrystoforova I, Polis B, Zvi IB, Karasik D. Acute hypoxia elevates arginase 2 and induces polyamine stress response in zebrafish via evolutionarily conserved mechanism. Cell Mol Life Sci. 2021 Dec 16; 79(1):41.
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Jasuja R, Costello JC, Singh R, Gupta V, Spina CS, Toraldo G, Jang H, Li H, Serra C, Guo W, Chauhan P, Narula NS, Guarneri T, Ergun A, Travison TG, Collins JJ, Bhasin S. Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy. Aging Cell. 2014 Apr; 13(2):303-10.
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Barry EL, Baron JA, Bhat S, Grau MV, Burke CA, Sandler RS, Ahnen DJ, Haile RW, O'Brien TG. Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. J Natl Cancer Inst. 2006 Oct 18; 98(20):1494-500.
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Dwivedi C, Valluri HB, Guan X, Agarwal R. Chemopreventive effects of alpha-santalol on ultraviolet B radiation-induced skin tumor development in SKH-1 hairless mice. Carcinogenesis. 2006 Sep; 27(9):1917-22.
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Topisirovic I, Kentsis A, Perez JM, Guzman ML, Jordan CT, Borden KL. Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels. Mol Cell Biol. 2005 Feb; 25(3):1100-12.
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Tosaka Y, Tanaka H, Yano Y, Masai K, Nozaki M, Yomogida K, Otani S, Nojima H, Nishimune Y. Identification and characterization of testis specific ornithine decarboxylase antizyme (OAZ-t) gene: expression in haploid germ cells and polyamine-induced frameshifting. Genes Cells. 2000 Apr; 5(4):265-76.
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Backous DD, Henley CM, Dunn JK, Jenkins HA. alpha-Difluoromethylornithine delays behavioral recovery and induces decompensation after unilateral labyrinthectomy. Otolaryngol Head Neck Surg. 1994 Oct; 111(4):377-84.
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Piccoletti R, Bendinelli P, Maroni P, Tacchini L, Bernelli-Zazzera A. Protein kinase C and gene expression in prolactin-stimulated postischemic livers. Ann N Y Acad Sci. 1994 Jun 17; 723:454-6.
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Sundberg JP, Erickson AA, Roop DR, Binder RL. Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10. Cancer Res. 1994 Mar 01; 54(5):1344-51.
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Reyland ME, Williams DL. Suppression of cAMP-mediated signal transduction in mouse adrenocortical cells which express apolipoprotein E. J Biol Chem. 1991 Nov 05; 266(31):21099-104.
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