 Phosphoenolpyruvate Carboxykinase (GTP)
"Phosphoenolpyruvate Carboxykinase (GTP)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the lyase class that catalyzes the conversion of GTP and oxaloacetate to GDP, phosphoenolpyruvate, and carbon dioxide. This reaction is part of gluconeogenesis in the liver. The enzyme occurs in both the mitochondria and cytosol of mammalian liver. (From Dorland, 27th ed) EC 4.1.1.32.
| Descriptor ID |
D010729
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| MeSH Number(s) |
D08.811.520.224.125.550
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| Concept/Terms |
Phosphoenolpyruvate Carboxykinase (GTP)- Phosphoenolpyruvate Carboxykinase (GTP)
- GTP-Dependent Phosphoenolpyruvate Carboxykinase
- Carboxykinase, GTP-Dependent Phosphoenolpyruvate
- GTP Dependent Phosphoenolpyruvate Carboxykinase
- Phosphoenolpyruvate Carboxykinase, GTP-Dependent
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Below are MeSH descriptors whose meaning is more general than "Phosphoenolpyruvate Carboxykinase (GTP)".
Below are MeSH descriptors whose meaning is more specific than "Phosphoenolpyruvate Carboxykinase (GTP)".
This graph shows the total number of publications written about "Phosphoenolpyruvate Carboxykinase (GTP)" by people in this website by year, and whether "Phosphoenolpyruvate Carboxykinase (GTP)" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 2 | 0 | 2 | | 1999 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphoenolpyruvate Carboxykinase (GTP)" by people in Profiles.
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Jo JR, An S, Ghosh S, Nedumaran B, Kim YD. Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2-YY1 signaling pathway. Sci Rep. 2021 09 23; 11(1):18999.
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Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 07 01; 311(1):R200-8.
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Li C, Shu ZJ, Lee S, Gupta MB, Jansson T, Nathanielsz PW, Kamat A. Effects of maternal nutrient restriction, intrauterine growth restriction, and glucocorticoid exposure on phosphoenolpyruvate carboxykinase-1 expression in fetal baboon hepatocytes in vitro. J Med Primatol. 2013 Aug; 42(4):211-9.
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Qadri I, Choudhury M, Rahman SM, Knotts TA, Janssen RC, Schaack J, Iwahashi M, Puljak L, Simon FR, Kilic G, Fitz JG, Friedman JE. Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein ?. J Biol Chem. 2012 Oct 26; 287(44):37340-51.
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Allen DL, Cleary AS, Lindsay SF, Loh AS, Reed JM. Myostatin expression is increased by food deprivation in a muscle-specific manner and contributes to muscle atrophy during prolonged food deprivation in mice. J Appl Physiol (1985). 2010 Sep; 109(3):692-701.
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Carlson GM, Holyoak T. Structural insights into the mechanism of phosphoenolpyruvate carboxykinase catalysis. J Biol Chem. 2009 Oct 02; 284(40):27037-41.
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Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE. Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinology. 2009 Jul; 150(7):3021-30.
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Stiffin RM, Sullivan SM, Carlson GM, Holyoak T. Differential inhibition of cytosolic PEPCK by substrate analogues. Kinetic and structural characterization of inhibitor recognition. Biochemistry. 2008 Feb 19; 47(7):2099-109.
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Limesand SW, Rozance PJ, Smith D, Hay WW. Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1716-25.
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Qiao L, MacLean PS, You H, Schaack J, Shao J. knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology. 2006 Jun; 147(6):3060-9.
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