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Matthew James Kennedy

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations

    Collapse Research 
    Collapse research activities and funding
    R01MH134957     (KENNEDY, MATTHEW J)Jan 1, 2024 - Dec 31, 2028
    NIH
    Evaluating the functional impact of synaptic nanoarchitecture
    Role: Principal Investigator
    R21MH134019     (KENNEDY, MATTHEW J)Aug 15, 2023 - Aug 14, 2025
    NIH
    Tools for manipulating protein condensates at the synapse
    Role: Principal Investigator
    R35NS116879     (KENNEDY, MATTHEW J)May 1, 2020 - Apr 30, 2028
    NIH
    Novel approaches for interrogating and manipulating synaptic function, structure and plasticity
    Role: Principal Investigator
    R01NS110383     (BAYER, K. ULRICH ;DELL'ACQUA, MARK L ;KENNEDY, MATTHEW J)Sep 30, 2018 - Jun 30, 2024
    NIH
    Postsynaptic kinase/phosphatase networks in amyloid beta-induced synaptic dysfunction
    Role: Co-Principal Investigator
    UF1NS107710     (KENNEDY, MATTHEW J)Sep 30, 2018 - Sep 29, 2021
    NIH
    Validating and extending optical tools for extended neural silencing
    Role: Principal Investigator
    R01NS107554     (KENNEDY, MATTHEW J)Jul 15, 2018 - Apr 30, 2023
    NIH
    Investigating Unconventional Secretory Trafficking in Neuronal Dendrites
    Role: Principal Investigator
    R21AG058005     (KENNEDY, MATTHEW J)Jan 1, 2017 - Dec 31, 2020
    NIH
    Mechanisms of beta-amyloid induced synaptic dysfunction
    Role: Principal Investigator
    R21EY026363     (KENNEDY, MATTHEW J)Sep 30, 2015 - Sep 29, 2018
    NIH
    Optical tools for extended neural silencing
    Role: Principal Investigator
    R01NS082271     (KENNEDY, MATTHEW J)Jun 15, 2013 - Apr 30, 2019
    NIH
    Mechanisms of dendritic exocytosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Welle TM, Rajgor D, Garcia JD, Kareemo D, Zych SM, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. bioRxiv. 2023 Dec 12. PMID: 38168421.
      View in: PubMed
    2. Olah SS, Kareemo DJ, Buchta WC, Sinnen BL, Miller CN, Actor-Engel HS, Gookin SE, Winborn CS, Kleinjan MS, Crosby KC, Aoto J, Smith KR, Kennedy MJ. Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Rep. 2023 11 28; 42(11):113331. PMID: 37910506.
      View in: PubMed
    3. Wang S, Chen X, Crisman L, Dou X, Winborn CS, Wan C, Puscher H, Yin Q, Kennedy MJ, Shen J. Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module. Sci Adv. 2023 02 22; 9(8):eade2540. PMID: 36812304.
      View in: PubMed
    4. Kleinjan MS, Buchta WC, Ogelman R, Hwang IW, Kuwajima M, Hubbard DD, Kareemo DJ, Prikhodko O, Olah SL, Gomez Wulschner LE, Abraham WC, Franco SJ, Harris KM, Oh WC, Kennedy MJ. Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk. Neuron. 2023 02 01; 111(3):362-371.e6. PMID: 36395772.
      View in: PubMed
    5. Barcomb K, Olah SS, Kennedy MJ, Ford CP. Properties and modulation of excitatory inputs to the locus coeruleus. J Physiol. 2022 Nov; 600(22):4897-4916. PMID: 36156249.
      View in: PubMed
    6. Gookin SE, Taylor MR, Schwartz SL, Kennedy MJ, Dell'Acqua ML, Crosby KC, Smith KR. Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses. Front Synaptic Neurosci. 2022; 14:852227. PMID: 35463850.
      View in: PubMed
    7. Bourke AM, Kennedy MJ. Spatial and Temporal Control of Protein Secretion with Light. Methods Mol Biol. 2022; 2473:29-45. PMID: 35819757.
      View in: PubMed
    8. Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR. Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity. Cell Rep. 2021 12 21; 37(12):110142. PMID: 34936876.
      View in: PubMed
    9. Actor-Engel HS, Schwartz SL, Crosby KC, Sinnen BL, Prikhodko O, Ramsay HJ, Bourne JN, Winborn CS, Lucas A, Smith KR, Dell'Acqua ML, Kennedy MJ. Precision Mapping of Amyloid-? Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits. eNeuro. 2021 Nov-Dec; 8(6). PMID: 34789478.
      View in: PubMed
    10. Bourke AM, Schwartz SL, Bowen AB, Kleinjan MS, Winborn CS, Kareemo DJ, Gutnick A, Schwarz TL, Kennedy MJ. zapERtrap: A light-regulated ER release system reveals unexpected neuronal trafficking pathways. J Cell Biol. 2021 09 06; 220(9). PMID: 34241635.
      View in: PubMed
    11. Restrepo S, Schwartz SL, Kennedy MJ, Aoto J. Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. J Vis Exp. 2020 05 22; (159). PMID: 32510501.
      View in: PubMed
    12. Kennedy MJ, Hanus C. Architecture and Dynamics of the Neuronal Secretory Network. Annu Rev Cell Dev Biol. 2019 10 06; 35:543-566. PMID: 31283381.
      View in: PubMed
    13. Wild AR, Sinnen BL, Dittmer PJ, Kennedy MJ, Sather WA, Dell'Acqua ML. Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma. Cell Rep. 2019 03 26; 26(13):3537-3550.e4. PMID: 30917310.
      View in: PubMed
    14. Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 03 06; 101(5):863-875.e6. PMID: 30704911.
      View in: PubMed
    15. Hiester BG, Becker MI, Bowen AB, Schwartz SL, Kennedy MJ. Mechanisms and Role of Dendritic Membrane Trafficking for Long-Term Potentiation. Front Cell Neurosci. 2018; 12:391. PMID: 30425622.
      View in: PubMed
    16. Bourke AM, Bowen AB, Kennedy MJ. New approaches for solving old problems in neuronal protein trafficking. Mol Cell Neurosci. 2018 09; 91:48-66. PMID: 29649542.
      View in: PubMed
    17. Hiester BG, Bourke AM, Sinnen BL, Cook SG, Gibson ES, Smith KR, Kennedy MJ. L-Type Voltage-Gated Ca2+ Channels Regulate Synaptic-Activity-Triggered Recycling Endosome Fusion in Neuronal Dendrites. Cell Rep. 2017 Nov 21; 21(8):2134-2146. PMID: 29166605.
      View in: PubMed
    18. Bowen AB, Bourke AM, Hiester BG, Hanus C, Kennedy MJ. Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines. Elife. 2017 09 06; 6. PMID: 28875935.
      View in: PubMed
    19. Sinnen BL, Bowen AB, Forte JS, Hiester BG, Crosby KC, Gibson ES, Dell'Acqua ML, Kennedy MJ. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017 Feb 08; 93(3):646-660.e5. PMID: 28132827.
      View in: PubMed
    20. Sinnen BL, Bowen AB, Gibson ES, Kennedy MJ. Local and Use-Dependent Effects of ?-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis. J Neurosci. 2016 11 09; 36(45):11532-11543. PMID: 27911757.
      View in: PubMed
    21. Taslimi A, Vrana JD, Chen D, Borinskaya S, Mayer BJ, Kennedy MJ, Tucker CL. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun. 2014 Sep 18; 5:4925. PMID: 25233328.
      View in: PubMed
    22. Tucker CL, Vrana JD, Kennedy MJ. Tools for controlling protein interactions using light. Curr Protoc Cell Biol. 2014 Sep 02; 64:17.16.1-20. PMID: 25181301.
      View in: PubMed
    23. Fox PD, Haberkorn CJ, Weigel AV, Higgins JL, Akin EJ, Kennedy MJ, Krapf D, Tamkun MM. Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubs. Mol Biol Cell. 2013 Sep; 24(17):2703-13. PMID: 23864710.
      View in: PubMed
    24. Chen D, Gibson ES, Kennedy MJ. A light-triggered protein secretion system. J Cell Biol. 2013 May 13; 201(4):631-40. PMID: 23671313.
      View in: PubMed
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