 Eukaryotic Initiation Factor-4A
"Eukaryotic Initiation Factor-4A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of eukaryotic initiation factor 4F that as an RNA helicase involved in unwinding the secondary structure of the 5' UNTRANSLATED REGION of MRNA. The unwinding facilitates the binding of the 40S ribosomal subunit.
| Descriptor ID |
D039601
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| MeSH Number(s) |
D08.811.913.696.445.735.720.500 D12.776.835.725.868.500.500
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| Concept/Terms |
Eukaryotic Initiation Factor-4A- Eukaryotic Initiation Factor-4A
- Eukaryotic Initiation Factor 4A
- Initiation Factor-4A, Eukaryotic
- EIF-4A
- Eukaryotic Peptide Initiation Factor-4A
- Eukaryotic Peptide Initiation Factor 4A
- Peptide Initiation Factor EIF-4A
- Peptide Initiation Factor EIF 4A
- Eukaryotic Initiation Factor EIF-4A
- Eukaryotic Initiation Factor EIF 4A
Eukaryotic Initiation Factor-4A2- Eukaryotic Initiation Factor-4A2
- Eukaryotic Initiation Factor 4A2
- Factor-4A2, Eukaryotic Initiation
- Initiation Factor-4A2, Eukaryotic
- EIF-4A2
Eukaryotic Initiation Factor-4A3- Eukaryotic Initiation Factor-4A3
- Eukaryotic Initiation Factor 4A3
- Factor-4A3, Eukaryotic Initiation
- Initiation Factor-4A3, Eukaryotic
- EIF-4A3
- EIF4AIII
- Eukaryotic Translation-Initiation Factor 4AIII
- Eukaryotic Translation Initiation Factor 4AIII
Eukaryotic Initiation Factor-4A1- Eukaryotic Initiation Factor-4A1
- Eukaryotic Initiation Factor 4A1
- Factor-4A1, Eukaryotic Initiation
- Initiation Factor-4A1, Eukaryotic
- EIF-4A1
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Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-4A".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-4A".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-4A" by people in this website by year, and whether "Eukaryotic Initiation Factor-4A" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-4A" by people in Profiles.
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Ripin N, Parker R. Are stress granules the RNA analogs of misfolded protein aggregates? RNA. 2022 01; 28(1):67-75.
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Tauber D, Tauber G, Khong A, Van Treeck B, Pelletier J, Parker R. Modulation of RNA Condensation by the DEAD-Box Protein eIF4A. Cell. 2020 02 06; 180(3):411-426.e16.
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Boehm V, Britto-Borges T, Steckelberg AL, Singh KK, Gerbracht JV, Gueney E, Blazquez L, Altm?ller J, Dieterich C, Gehring NH. Exon Junction Complexes Suppress Spurious Splice Sites to Safeguard Transcriptome Integrity. Mol Cell. 2018 11 01; 72(3):482-495.e7.
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Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017 03; 13(3):e1006658.
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Gromadzka AM, Steckelberg AL, Singh KK, Hofmann K, Gehring NH. A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. Nucleic Acids Res. 2016 Mar 18; 44(5):2348-61.
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Steckelberg AL, Altmueller J, Dieterich C, Gehring NH. CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes. Nucleic Acids Res. 2015 May 19; 43(9):4687-700.
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Steckelberg AL, Boehm V, Gromadzka AM, Gehring NH. CWC22 connects pre-mRNA splicing and exon junction complex assembly. Cell Rep. 2012 Sep 27; 2(3):454-61.
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Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E, Zukin RS. Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci. 2010 Jan 13; 30(2):694-702.
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