 Interferon-Induced Helicase, IFIH1
"Interferon-Induced Helicase, IFIH1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.
| Descriptor ID |
D000072640
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| MeSH Number(s) |
D08.811.913.696.445.735.720.249.875
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| Concept/Terms |
Interferon-Induced Helicase, IFIH1- Interferon-Induced Helicase, IFIH1
- Helicase, IFIH1 Interferon-Induced
- IFIH1 Interferon-Induced Helicase
- Interferon Induced Helicase, IFIH1
- Helicard
- Melanoma Differentiation-Associated Protein 5
- Melanoma Differentiation Associated Protein 5
- CADM-140 Autoantigen
- Autoantigen, CADM-140
- CADM 140 Autoantigen
- Interferon Induced with Helicase C Domain 1
- Interferon-Induced Helicase C Domain-Containing Protein 1
- Interferon Induced Helicase C Domain Containing Protein 1
- IFIH1 Protein
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Below are MeSH descriptors whose meaning is more general than "Interferon-Induced Helicase, IFIH1".
Below are MeSH descriptors whose meaning is more specific than "Interferon-Induced Helicase, IFIH1".
This graph shows the total number of publications written about "Interferon-Induced Helicase, IFIH1" by people in this website by year, and whether "Interferon-Induced Helicase, IFIH1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2020 | 2 | 1 | 3 | | 2021 | 1 | 1 | 2 | | 2022 | 0 | 1 | 1 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interferon-Induced Helicase, IFIH1" by people in Profiles.
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Yamazaki S, Shimizu M, Yakabe A, Inage E, Jimbo K, Suzuki M, Miyaoka F, Kaneko S, Irabu H, Shimbo A, Ohtomo Y, Mori M, Morio T, Shimizu T. Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature. Immunol Med. 2024 Jun; 47(2):110-117.
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Blum SI, Taylor JP, Barra JM, Burg AR, Shang Q, Qiu S, Shechter O, Hayes AR, Green TJ, Geurts AM, Chen YG, Tse HM. MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance. JCI Insight. 2023 Jan 24; 8(2).
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Riella CV, McNulty M, Ribas GT, Tattersfield CF, Perez-Gill C, Eichinger F, Kelly J, Chun J, Subramanian B, Guizelini D, Alper SL, Pollak MR, Sampson MG, Friedman DJ. ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2210150119.
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Chitrakar A, Solorio-Kirpichyan K, Prangley E, Rath S, Du J, Korennykh A. Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L. Proc Natl Acad Sci U S A. 2021 11 16; 118(46).
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Sabbagh SE, Neely J, Chow A, DeGuzman M, Lai J, Lvovich S, McGrath T, Pereira M, Pinal-Fernandez I, Roberts J, Rouster-Stevens K, Schmeling H, Sura A, Tarshish G, Tucker L, Rider LG, Kim S. Risk factors associated with Pneumocystis jirovecii pneumonia in juvenile myositis in North America. Rheumatology (Oxford). 2021 02 01; 60(2):829-836.
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Kunitomo Y, Young G, Datta R, Korn LL, Tanoue L, Gautam S. A 62-Year-Old Woman With Lung Cancer, Ulcerating Rash, and Rapidly Progressive Hypoxemia. Chest. 2020 10; 158(4):e191-e196.
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Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease. J Virol. 2020 04 16; 94(9).
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Bankers L, Miller C, Liu G, Thongkittidilok C, Morrison J, Poeschla EM. Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation. J Immunol. 2020 05 15; 204(10):2791-2807.
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Gilani A, Adang LA, Vanderver A, Collins A, Kleinschmidt-DeMasters BK. Neuropathological Findings in a Case of IFIH1-Related Aicardi-Gouti?res Syndrome. Pediatr Dev Pathol. 2019 Nov-Dec; 22(6):566-570.
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Adang LA, Frank DB, Gilani A, Takanohashi A, Ulrick N, Collins A, Cross Z, Galambos C, Helman G, Kanaan U, Keller S, Simon D, Sherbini O, Hanna BD, Vanderver AL. Aicardi gouti?res syndrome is associated with pulmonary hypertension. Mol Genet Metab. 2018 12; 125(4):351-358.
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