 Sphingosine N-Acyltransferase
"Sphingosine N-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The enzyme is mainly localized in the MITOCHONDRIA.
| Descriptor ID |
D051049
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| MeSH Number(s) |
D08.811.913.050.712
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| Concept/Terms |
Sphingosine N-Acyltransferase- Sphingosine N-Acyltransferase
- N-Acyltransferase, Sphingosine
- Sphingosine N Acyltransferase
- Sphingosine Acyltransferase
- Acyltransferase, Sphingosine
- Ceramide Synthetase
- Synthetase, Ceramide
- Fatty Acyl-CoA - Sphingosine Acyltransferase
- Fatty Acyl CoA Sphingosine Acyltransferase
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Below are MeSH descriptors whose meaning is more general than "Sphingosine N-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Sphingosine N-Acyltransferase".
This graph shows the total number of publications written about "Sphingosine N-Acyltransferase" by people in this website by year, and whether "Sphingosine N-Acyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2011 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Sphingosine N-Acyltransferase" by people in Profiles.
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Amatruda M, Marechal D, Gacias M, Wentling M, Turpin-Nolan S, Morstein J, Moniruzzaman M, Brüning JC, Haughey NJ, Trauner DH, Casaccia P. Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis. Glia. 2025 Feb; 73(2):271-290.
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Kenney HM, Yoshida T, Berdyshev E, Calatroni A, Gill SR, Simpson EL, Lussier S, Boguniewicz M, Hata T, Chiesa Fuxench ZC, De Benedetto A, Ong PY, Ko J, Davidson W, David G, Schlievert PM, Leung DYM, Beck LA. CERS1 is a biomarker of Staphylococcus aureus abundance and atopic dermatitis severity. J Allergy Clin Immunol. 2025 Feb; 155(2):479-490.
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Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I. Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J. 2018 04; 32(4):1880-1890.
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Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI. SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22; 291(4):1957-1973.
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Petrache I, Kamocki K, Poirier C, Pewzner-Jung Y, Laviad EL, Schweitzer KS, Van Demark M, Justice MJ, Hubbard WC, Futerman AH. Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. PLoS One. 2013; 8(5):e62968.
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Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063.
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