 Sterol O-Acyltransferase
"Sterol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.
| Descriptor ID |
D002785
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| MeSH Number(s) |
D08.811.913.050.799
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| Concept/Terms |
Sterol O-Acyltransferase- Sterol O-Acyltransferase
- O-Acyltransferase, Sterol
- Sterol O Acyltransferase
- Cholesterol Esterifying Enzyme
- Enzyme, Cholesterol Esterifying
- Esterifying Enzyme, Cholesterol
- Acyl-CoA-Cholesterol Acyltransferase
- Acyl CoA Cholesterol Acyltransferase
- Acyltransferase, Acyl-CoA-Cholesterol
- Cholesterol Acyltransferase
- Acyltransferase, Cholesterol
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Below are MeSH descriptors whose meaning is more general than "Sterol O-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Sterol O-Acyltransferase".
This graph shows the total number of publications written about "Sterol O-Acyltransferase" by people in this website by year, and whether "Sterol O-Acyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Sterol O-Acyltransferase" by people in Profiles.
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Bonaca MP, Morrow DA, Bergmark BA, Berg DD, Lima JAC, Hoffmann U, Kato Y, Lu MT, Kuder J, Murphy SA, Spinar J, Oude Ophuis T, Kiss RG, Lopez-Sendon J, Averkov O, Wheatcroft SB, Kubica J, Carlos Nicolau J, Furtado RHM, Abuhatzira L, Hirshberg B, Omar SA, Vavere AL, Chang YT, George RT, Sabatine MS. Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B. Circulation. 2022 09 20; 146(12):907-916.
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Bonaca MP, George RT, Morrow DA, Bergmark BA, Park JG, Abuhatzira L, Vavere AL, Karathanasis SK, Jin C, She D, Hirshberg B, Hsia J, Sabatine MS. Recombinant human lecithin-cholesterol acyltransferase in patients with atherosclerosis: phase 2a primary results and phase 2b design. Eur Heart J Cardiovasc Pharmacother. 2022 05 05; 8(3):243-252.
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Nishikawa Y, Quittnat F, Stedman TT, Voelker DR, Choi JY, Zahn M, Yang M, Pypaert M, Joiner KA, Coppens I. Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma. Cell Microbiol. 2005 Jun; 7(6):849-67.
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Hiatt WR, Klepack E, Nehler M, Regensteiner JG, Blue J, Imus J, Criqui MH. The effect of inhibition of acyl coenzyme A-cholesterol acyltransferase (ACAT) on exercise performance in patients with peripheral arterial disease. Vasc Med. 2004 Nov; 9(4):271-7.
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Leventhal AR, Leslie CC, Tabas I. Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking. J Biol Chem. 2004 Feb 27; 279(9):8084-92.
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