 Serine C-Palmitoyltransferase
"Serine C-Palmitoyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A key enzyme in SPHINGOLIPIDS biosynthesis, this enzyme catalyzes the pyridoxal-5'-phosphate-dependent condensation of L-SERINE and PALMITOYL COENZYME A to 3-dehydro-D-sphinganine. The enzyme consists of two different subunits.
| Descriptor ID |
D051102
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| MeSH Number(s) |
D08.811.913.050.668
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| Concept/Terms |
Serine C-Palmitoyltransferase- Serine C-Palmitoyltransferase
- C-Palmitoyltransferase, Serine
- Serine C Palmitoyltransferase
- Serine Palmitoyltransferase
- Palmitoyltransferase, Serine
- Palmitoyl-CoA-L-Serine C-Palmitoyltransferase (Decarboxylating)
- Palmitoyl-Coenzyme A-L-Serine C-Palmitoyltransferase (Decarboxylating)
Long Chain Base Biosynthesis Protein 2- Long Chain Base Biosynthesis Protein 2
- Serine-Palmitoyl-CoA Transferase 2
- Serine Palmitoyl CoA Transferase 2
- Transferase 2, Serine-Palmitoyl-CoA
- Serine Palmitoyltransferase 2
- Palmitoyltransferase 2, Serine
- Serine Palmitoyltransferase, Long Chain Base Subunit 2
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Below are MeSH descriptors whose meaning is more general than "Serine C-Palmitoyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Serine C-Palmitoyltransferase".
This graph shows the total number of publications written about "Serine C-Palmitoyltransferase" by people in this website by year, and whether "Serine C-Palmitoyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Serine C-Palmitoyltransferase" by people in Profiles.
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Piccolo BD, Graham JL, Kang P, Randolph CE, Shankar K, Yeruva L, Fox R, Robeson MS, Moody B, LeRoith T, Stanhope KL, Adams SH, Havel PJ. Progression of diabetes is associated with changes in the ileal transcriptome and ileal-colon morphology in the UC Davis Type 2 Diabetes Mellitus rat. Physiol Rep. 2021 11; 9(22):e15102.
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Fridman V, Suriyanarayanan S, Novak P, David W, Macklin EA, McKenna-Yasek D, Walsh K, Aziz-Bose R, Oaklander AL, Brown R, Hornemann T, Eichler F. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019 01 22; 92(4):e359-e370.
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Ndengele MM, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Muscoli C, Petrusca DN, Mollace V, Mazzon E, Li D, Petrache I, Matuschak GM, Salvemini D. Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. J Pharmacol Exp Ther. 2009 Apr; 329(1):64-75.
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Medler TR, Petrusca DN, Lee PJ, Hubbard WC, Berdyshev EV, Skirball J, Kamocki K, Schuchman E, Tuder RM, Petrache I. Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):639-46.
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Petrache I, Natarajan V, Zhen L, Medler TR, Richter AT, Cho C, Hubbard WC, Berdyshev EV, Tuder RM. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med. 2005 May; 11(5):491-8.
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Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E599-607.
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