 Interleukin-1alpha
"Interleukin-1alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.
| Descriptor ID |
D053582
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| MeSH Number(s) |
D12.644.276.374.465.010.300 D12.644.276.374.500.400.300 D12.776.467.374.465.010.300 D12.776.467.374.500.400.300 D23.529.374.465.131.300 D23.529.374.500.400.300
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| Concept/Terms |
Interleukin-1alpha- Interleukin-1alpha
- Interleukin 1alpha
- IL-1 alpha
- Interleukin-1 alpha
- Interleukin 1 alpha
- Hematopoietin-1
- Hematopoietin 1
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Below are MeSH descriptors whose meaning is more general than "Interleukin-1alpha".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1alpha".
This graph shows the total number of publications written about "Interleukin-1alpha" by people in this website by year, and whether "Interleukin-1alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 2 | 0 | 2 | | 2007 | 3 | 3 | 6 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 1 | 3 | | 2010 | 2 | 0 | 2 | | 2011 | 5 | 1 | 6 | | 2012 | 1 | 1 | 2 | | 2013 | 3 | 1 | 4 | | 2014 | 3 | 2 | 5 | | 2015 | 2 | 1 | 3 | | 2017 | 1 | 1 | 2 | | 2018 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 4 | 5 | | 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Interleukin-1alpha" by people in Profiles.
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LaRocca TJ, Cavalier AN, Roberts CM, Lemieux MR, Ramesh P, Garcia MA, Link CD. Amyloid beta acts synergistically as a pro-inflammatory cytokine. Neurobiol Dis. 2021 11; 159:105493.
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Cavalli G, Colafrancesco S, Emmi G, Imazio M, Lopalco G, Maggio MC, Sota J, Dinarello CA. Interleukin 1a: a comprehensive review on the role of IL-1a in the pathogenesis and treatment of autoimmune and inflammatory diseases. Autoimmun Rev. 2021 Mar; 20(3):102763.
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Kanni T, Argyropoulou M, Dinarello CA, Simard J, Giamarellos-Bourboulis EJ. MABp1 targeting interleukin-1a in hidradenitis suppurativa ineligible for adalimumab treatment: results of the open-label extension period. Clin Exp Dermatol. 2021 Jan; 46(1):162-163.
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Ogawa T, Ishitsuka Y, Nakamura Y, Kubota N, Saito A, Fujisawa Y, Watanabe R, Okiyama N, Suga Y, Roop DR, Fujimoto M. NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy. J Immunol. 2020 08 15; 205(4):907-914.
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James JA, Guthridge JM, Chen H, Lu R, Bourn RL, Bean K, Munroe ME, Smith M, Chakravarty E, Baer AN, Noaiseh G, Parke A, Boyle K, Keyes-Elstein L, Coca A, Utset T, Genovese MC, Pascual V, Utz PJ, Holers VM, Deane KD, Sivils KL, Aberle T, Wallace DJ, McNamara J, Franchimont N, St Clair EW. Unique Sj?gren's syndrome patient subsets defined by molecular features. Rheumatology (Oxford). 2020 04 01; 59(4):860-868.
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De Dios R, Nguyen L, Ghosh S, McKenna S, Wright CJ. CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NF?B inhibitory protein I?B? to drive IL1a and IL1? expression. Immunology. 2020 05; 160(1):64-77.
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Tian T, Lofftus S, Pan Y, Stingley CA, King SL, Zhao J, Pan TY, Lock R, Marglous JW, Liu K, Widlund HR, Fuhlbrigge RC, Cichowski K, Kupper TS. IL1a Antagonizes IL1? and Promotes Adaptive Immune Rejection of Malignant Tumors. Cancer Immunol Res. 2020 05; 8(5):660-671.
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Butler B, De Dios R, Nguyen L, McKenna S, Ghosh S, Wright CJ. Developmentally Regulated Innate Immune NF?B Signaling Mediates IL-1a Expression in the Perinatal Murine Lung. Front Immunol. 2019; 10:1555.
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Voronov E, Dinarello CA, Apte RN. Interleukin-1a as an intracellular alarmin in cancer biology. Semin Immunol. 2018 08; 38:3-14.
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Singh AK, Fechtner S, Chourasia M, Sicalo J, Ahmed S. Critical role of IL-1a in IL-1?-induced inflammatory responses: cooperation with NF-?Bp65 in transcriptional regulation. FASEB J. 2019 02; 33(2):2526-2536.
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