 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
| Descriptor ID |
D015632
|
| MeSH Number(s) |
D03.383.725.450
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine".
This graph shows the total number of publications written about "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" by people in this website by year, and whether "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" by people in Profiles.
-
Hammond SL, Popichak KA, Li X, Hunt LG, Richman EH, Damale PU, Chong EKP, Backos DS, Safe S, Tjalkens RB. The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism. J Pharmacol Exp Ther. 2018 06; 365(3):636-651.
-
Liang LP, Huang J, Fulton R, Pearson-Smith JN, Day BJ, Patel M. Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease. Toxicol Appl Pharmacol. 2017 07 01; 326:34-42.
-
Miller JA, Trout BR, Sullivan KA, Bialecki RA, Roberts RA, Tjalkens RB. Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-?B reporter mice prior to loss of dopaminergic neurons. J Neurosci Res. 2011 Mar; 89(3):406-17.
-
H?glinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, Degregori J, Oertel WH, Rakic P, Hirsch EC, Hunot S. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3585-90.
-
Quik M, Sum JD, Whiteaker P, McCallum SE, Marks MJ, Musachio J, McIntosh JM, Collins AC, Grady SR. Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice. Mol Pharmacol. 2003 May; 63(5):1169-79.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|