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Sharon R Grady

TitleAffiliate
InstitutionUniversity of Colorado Boulder
DepartmentInstitute for Behav Genetics
Phone492-9677

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Parker RL, O'Neill HC, Henley BM, Wageman CR, Drenan RM, Marks MJ, Miwa JM, Grady SR, Lester HA. Deletion of lynx1 reduces the function of a6* nicotinic receptors. PLoS One. 2017; 12(12):e0188715. PMID: 29206881.
      View in: PubMed
    2. Wall TR, Henderson BJ, Voren G, Wageman CR, Deshpande P, Cohen BN, Grady SR, Marks MJ, Yohannes D, Kenny PJ, Bencherif M, Lester HA. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Front Pharmacol. 2017; 8:641. PMID: 29033834.
      View in: PubMed
    3. McClure-Begley TD, Esterlis I, Stone KL, Lam TT, Grady SR, Colangelo CM, Lindstrom JM, Marks MJ, Picciotto MR. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. eNeuro. 2016 Jul-Aug; 3(4). PMID: 27559543.
      View in: PubMed
    4. Marks MJ, O'Neill HC, Wynalda-Camozzi KM, Ortiz NC, Simmons EE, Short CA, Butt CM, McIntosh JM, Grady SR. Chronic treatment with varenicline changes expression of four nAChR binding sites in mice. Neuropharmacology. 2015 Dec; 99:142-55. PMID: 26192545.
      View in: PubMed
    5. Zambrano CA, Short CA, Salamander RM, Grady SR, Marks MJ. Density of a4?2* nAChR on the surface of neurons is modulated by chronic antagonist exposure. Pharmacol Res Perspect. 2015 Mar; 3(2):e00111. PMID: 25729578.
      View in: PubMed
    6. McClure-Begley TD, Grady SR, Marks MJ, Collins AC, Stitzel JA. Presynaptic GABAB autoreceptor regulation of nicotinic acetylcholine receptor mediated [(3)H]-GABA release from mouse synaptosomes. Biochem Pharmacol. 2014 Sep 01; 91(1):87-96. PMID: 24953818.
      View in: PubMed
    7. Marks MJ, Grady SR, Salminen O, Paley MA, Wageman CR, McIntosh JM, Whiteaker P. a6?2*-subtype nicotinic acetylcholine receptors are more sensitive than a4?2*-subtype receptors to regulation by chronic nicotine administration. J Neurochem. 2014 Jul; 130(2):185-98. PMID: 24661093.
      View in: PubMed
    8. Wang Y, Lee JW, Oh G, Grady SR, McIntosh JM, Brunzell DH, Cannon JR, Drenan RM. Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function a6* nAChRs. J Neurochem. 2014 Apr; 129(2):315-27. PMID: 24266758.
      View in: PubMed
    9. Wageman CR, Marks MJ, Grady SR. Effectiveness of nicotinic agonists as desensitizers at presynaptic a4?2- and a4a5?2-nicotinic acetylcholine receptors. Nicotine Tob Res. 2014 Mar; 16(3):297-305. PMID: 24052501.
      View in: PubMed
    10. McClure-Begley TD, Stone KL, Marks MJ, Grady SR, Colangelo CM, Lindstrom JM, Picciotto MR. Exploring the nicotinic acetylcholine receptor-associated proteome with iTRAQ and transgenic mice. Genomics Proteomics Bioinformatics. 2013 Aug; 11(4):207-18. PMID: 23891776.
      View in: PubMed
    11. Quik M, Campos C, Grady SR. Multiple CNS nicotinic receptors mediate L-dopa-induced dyskinesias: studies with parkinsonian nicotinic receptor knockout mice. Biochem Pharmacol. 2013 Oct 15; 86(8):1153-62. PMID: 23831952.
      View in: PubMed
    12. Soll LG, Grady SR, Salminen O, Marks MJ, Tapper AR. A role for a4(non-a6)* nicotinic acetylcholine receptors in motor behavior. Neuropharmacology. 2013 Oct; 73:19-30. PMID: 23688922.
      View in: PubMed
    13. Sala M, Braida D, Pucci L, Manfredi I, Marks MJ, Wageman CR, Grady SR, Loi B, Fucile S, Fasoli F, Zoli M, Tasso B, Sparatore F, Clementi F, Gotti C. CC4, a dimer of cytisine, is a selective partial agonist at a4?2/a6?2 nAChR with improved selectivity for tobacco smoking cessation. Br J Pharmacol. 2013 Feb; 168(4):835-49. PMID: 22957729.
      View in: PubMed
    14. O'Neill HC, Laverty DC, Patzlaff NE, Cohen BN, Fonck C, McKinney S, McIntosh JM, Lindstrom JM, Lester HA, Grady SR, Marks MJ. Mice expressing the ADNFLE valine 287 leucine mutation of the ?2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function. Pharmacol Biochem Behav. 2013 Jan; 103(3):603-21. PMID: 23123803.
      View in: PubMed
    15. Mackey ED, Engle SE, Kim MR, O'Neill HC, Wageman CR, Patzlaff NE, Wang Y, Grady SR, McIntosh JM, Marks MJ, Lester HA, Drenan RM. a6* nicotinic acetylcholine receptor expression and function in a visual salience circuit. J Neurosci. 2012 Jul 25; 32(30):10226-37. PMID: 22836257.
      View in: PubMed
    16. McClure-Begley TD, Wageman CR, Grady SR, Marks MJ, McIntosh JM, Collins AC, Whiteaker P. A novel a-conotoxin MII-sensitive nicotinic acetylcholine receptor modulates [(3) H]-GABA release in the superficial layers of the mouse superior colliculus. J Neurochem. 2012 Jul; 122(1):48-57. PMID: 22506481.
      View in: PubMed
    17. Quik M, Park KM, Hrachova M, Mallela A, Huang LZ, McIntosh JM, Grady SR. Role for a6 nicotinic receptors in l-dopa-induced dyskinesias in parkinsonian mice. Neuropharmacology. 2012 Sep; 63(3):450-9. PMID: 22579614.
      View in: PubMed
    18. Zambrano CA, Salamander RM, Collins AC, Grady SR, Marks MJ. Regulation of the distribution and function of [(125)I]epibatidine binding sites by chronic nicotine in mouse embryonic neuronal cultures. J Pharmacol Exp Ther. 2012 Aug; 342(2):245-54. PMID: 22532626.
      View in: PubMed
    19. Ortiz NC, O'Neill HC, Marks MJ, Grady SR. Varenicline blocks ?2*-nAChR-mediated response and activates ?4*-nAChR-mediated responses in mice in vivo. Nicotine Tob Res. 2012 Jun; 14(6):711-9. PMID: 22241831.
      View in: PubMed
    20. Grady SR, Wageman CR, Patzlaff NE, Marks MJ. Low concentrations of nicotine differentially desensitize nicotinic acetylcholine receptors that include a5 or a6 subunits and that mediate synaptosomal neurotransmitter release. Neuropharmacology. 2012 Apr; 62(5-6):1935-43. PMID: 22239849.
      View in: PubMed
    21. McGranahan TM, Patzlaff NE, Grady SR, Heinemann SF, Booker TK. a4?2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. J Neurosci. 2011 Jul 27; 31(30):10891-902. PMID: 21795541.
      View in: PubMed
    22. Quik M, Perez XA, Grady SR. Role of a6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders. Biochem Pharmacol. 2011 Oct 15; 82(8):873-82. PMID: 21684266.
      View in: PubMed
    23. Huang LZ, Grady SR, Quik M. Nicotine reduces L-DOPA-induced dyskinesias by acting at beta2* nicotinic receptors. J Pharmacol Exp Ther. 2011 Sep; 338(3):932-41. PMID: 21665941.
      View in: PubMed
    24. Zhao-Shea R, Liu L, Soll LG, Improgo MR, Meyers EE, McIntosh JM, Grady SR, Marks MJ, Gardner PD, Tapper AR. Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area. Neuropsychopharmacology. 2011 Apr; 36(5):1021-32. PMID: 21289604.
      View in: PubMed
    25. Drenan RM, Grady SR, Steele AD, McKinney S, Patzlaff NE, McIntosh JM, Marks MJ, Miwa JM, Lester HA. Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors. J Neurosci. 2010 Jul 21; 30(29):9877-89. PMID: 20660270.
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    26. Grady SR, Drenan RM, Breining SR, Yohannes D, Wageman CR, Fedorov NB, McKinney S, Whiteaker P, Bencherif M, Lester HA, Marks MJ. Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors. Neuropharmacology. 2010 Jun; 58(7):1054-66. PMID: 20114055.
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    27. Zhao-Shea R, Cohen BN, Just H, McClure-Begley T, Whiteaker P, Grady SR, Salminen O, Gardner PD, Lester HA, Tapper AR. Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism. FASEB J. 2010 Jan; 24(1):49-57. PMID: 19720621.
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    28. Grady SR, Salminen O, McIntosh JM, Marks MJ, Collins AC. Mouse striatal dopamine nerve terminals express alpha4alpha5beta2 and two stoichiometric forms of alpha4beta2*-nicotinic acetylcholine receptors. J Mol Neurosci. 2010 Jan; 40(1-2):91-5. PMID: 19693710.
      View in: PubMed
    29. Marks MJ, Laverty DS, Whiteaker P, Salminen O, Grady SR, McIntosh JM, Collins AC. John Daly's compound, epibatidine, facilitates identification of nicotinic receptor subtypes. J Mol Neurosci. 2010 Jan; 40(1-2):96-104. PMID: 19672723.
      View in: PubMed
    30. Breining SR, Bencherif M, Grady SR, Whiteaker P, Marks MJ, Wageman CR, Lester HA, Yohannes D. Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4359-63. PMID: 19560354.
      View in: PubMed
    31. Marks MJ, Wageman CR, Grady SR, Gopalakrishnan M, Briggs CA. Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain. Biochem Pharmacol. 2009 Oct 01; 78(7):795-802. PMID: 19481067.
      View in: PubMed
    32. Grady SR, Moretti M, Zoli M, Marks MJ, Zanardi A, Pucci L, Clementi F, Gotti C. Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release. J Neurosci. 2009 Feb 18; 29(7):2272-82. PMID: 19228980.
      View in: PubMed
    33. Collins AC, Salminen O, Marks MJ, Whiteaker P, Grady SR. The road to discovery of neuronal nicotinic cholinergic receptor subtypes. Handb Exp Pharmacol. 2009; (192):85-112. PMID: 19184647.
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    34. Drenan RM, Grady SR, Whiteaker P, McClure-Begley T, McKinney S, Miwa JM, Bupp S, Heintz N, McIntosh JM, Bencherif M, Marks MJ, Lester HA. In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors. Neuron. 2008 Oct 09; 60(1):123-36. PMID: 18940593.
      View in: PubMed
    35. Perez XA, Bordia T, McIntosh JM, Grady SR, Quik M. Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function. Mol Pharmacol. 2008 Sep; 74(3):844-53. PMID: 18583454.
      View in: PubMed
    36. Teper Y, Whyte D, Cahir E, Lester HA, Grady SR, Marks MJ, Cohen BN, Fonck C, McClure-Begley T, McIntosh JM, Labarca C, Lawrence A, Chen F, Gantois I, Davies PJ, Petrou S, Murphy M, Waddington J, Horne MK, Berkovic SF, Drago J. Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation. J Neurosci. 2007 Sep 19; 27(38):10128-42. PMID: 17881519.
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    37. Nashmi R, Xiao C, Deshpande P, McKinney S, Grady SR, Whiteaker P, Huang Q, McClure-Begley T, Lindstrom JM, Labarca C, Collins AC, Marks MJ, Lester HA. Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path. J Neurosci. 2007 Aug 01; 27(31):8202-18. PMID: 17670967.
      View in: PubMed
    38. Grady SR, Salminen O, Laverty DC, Whiteaker P, McIntosh JM, Collins AC, Marks MJ. The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum. Biochem Pharmacol. 2007 Oct 15; 74(8):1235-46. PMID: 17825262.
      View in: PubMed
    39. Bordia T, Grady SR, McIntosh JM, Quik M. Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum. Mol Pharmacol. 2007 Jul; 72(1):52-61. PMID: 17409284.
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    40. Salminen O, Drapeau JA, McIntosh JM, Collins AC, Marks MJ, Grady SR. Pharmacology of alpha-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice. Mol Pharmacol. 2007 Jun; 71(6):1563-71. PMID: 17341654.
      View in: PubMed
    41. Matta SG, Balfour DJ, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, Lukas RJ, Markou A, Marks MJ, McCallum SE, Parameswaran N, Perkins KA, Picciotto MR, Quik M, Rose JE, Rothenfluh A, Schafer WR, Stolerman IP, Tyndale RF, Wehner JM, Zirger JM. Guidelines on nicotine dose selection for in vivo research. Psychopharmacology (Berl). 2007 Feb; 190(3):269-319. PMID: 16896961.
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    42. McCallum SE, Parameswaran N, Bordia T, McIntosh JM, Grady SR, Quik M. Decrease in alpha3*/alpha6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damage. Mol Pharmacol. 2005 Sep; 68(3):737-46. PMID: 15933214.
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    43. Salminen O, Whiteaker P, Grady SR, Collins AC, McIntosh JM, Marks MJ. The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay. Neuropharmacology. 2005 Apr; 48(5):696-705. PMID: 15814104.
      View in: PubMed
    44. Lai A, Parameswaran N, Khwaja M, Whiteaker P, Lindstrom JM, Fan H, McIntosh JM, Grady SR, Quik M. Long-term nicotine treatment decreases striatal alpha 6* nicotinic acetylcholine receptor sites and function in mice. Mol Pharmacol. 2005 May; 67(5):1639-47. PMID: 15681595.
      View in: PubMed
    45. Marks MJ, Rowell PP, Cao JZ, Grady SR, McCallum SE, Collins AC. Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment. Neuropharmacology. 2004 Jun; 46(8):1141-57. PMID: 15111021.
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    46. Salminen O, Murphy KL, McIntosh JM, Drago J, Marks MJ, Collins AC, Grady SR. Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice. Mol Pharmacol. 2004 Jun; 65(6):1526-35. PMID: 15155845.
      View in: PubMed
    47. Cui C, Booker TK, Allen RS, Grady SR, Whiteaker P, Marks MJ, Salminen O, Tritto T, Butt CM, Allen WR, Stitzel JA, McIntosh JM, Boulter J, Collins AC, Heinemann SF. The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. J Neurosci. 2003 Dec 03; 23(35):11045-53. PMID: 14657161.
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    48. Quik M, Sum JD, Whiteaker P, McCallum SE, Marks MJ, Musachio J, McIntosh JM, Collins AC, Grady SR. Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice. Mol Pharmacol. 2003 May; 63(5):1169-79. PMID: 12695545.
      View in: PubMed
    49. King SL, Marks MJ, Grady SR, Caldarone BJ, Koren AO, Mukhin AG, Collins AC, Picciotto MR. Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. J Neurosci. 2003 May 01; 23(9):3837-43. PMID: 12736354.
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    50. Marks MJ, Whiteaker P, Grady SR, Picciotto MR, McIntosh JM, Collins AC. Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice. J Neurochem. 2002 Jun; 81(5):1102-15. PMID: 12065623.
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    51. Grady SR, Murphy KL, Cao J, Marks MJ, McIntosh JM, Collins AC. Characterization of nicotinic agonist-induced [(3)H]dopamine release from synaptosomes prepared from four mouse brain regions. J Pharmacol Exp Ther. 2002 May; 301(2):651-60. PMID: 11961070.
      View in: PubMed
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