 Nicotine
"Nicotine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
| Descriptor ID |
D009538
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| MeSH Number(s) |
D03.132.760.570 D03.383.725.518
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nicotine".
Below are MeSH descriptors whose meaning is more specific than "Nicotine".
This graph shows the total number of publications written about "Nicotine" by people in this website by year, and whether "Nicotine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1997 | 1 | 0 | 1 | | 1998 | 3 | 0 | 3 | | 1999 | 4 | 1 | 5 | | 2000 | 5 | 4 | 9 | | 2001 | 4 | 0 | 4 | | 2002 | 2 | 1 | 3 | | 2003 | 6 | 6 | 12 | | 2004 | 10 | 1 | 11 | | 2005 | 9 | 2 | 11 | | 2006 | 5 | 3 | 8 | | 2007 | 6 | 3 | 9 | | 2008 | 3 | 4 | 7 | | 2009 | 6 | 4 | 10 | | 2010 | 4 | 3 | 7 | | 2011 | 9 | 1 | 10 | | 2012 | 11 | 9 | 20 | | 2013 | 5 | 6 | 11 | | 2014 | 6 | 2 | 8 | | 2015 | 4 | 3 | 7 | | 2016 | 3 | 1 | 4 | | 2017 | 4 | 2 | 6 | | 2018 | 7 | 3 | 10 | | 2019 | 2 | 2 | 4 | | 2020 | 7 | 3 | 10 | | 2021 | 6 | 4 | 10 | | 2022 | 3 | 8 | 11 | | 2023 | 2 | 3 | 5 | | 2024 | 4 | 2 | 6 | | 2025 | 4 | 1 | 5 | | 2026 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Nicotine" by people in Profiles.
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Kumar PS, Beverly ML, Galindo-Fernandez P, Thompson W, Verma M, Shick E. To Vape or Not to Vape: Oral Health in the Age of Electronic Nicotine Delivery Systems and Electronic Non-Nicotine Delivery Systems. Int Dent J. 2026 Jun; 76(3):109523.
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Buck JM, Melnick M, Stitzel JA. Developmental Nicotine Exposure Induces Intergenerational Transmission of an Ensemble of Neurodevelopmental Disorder-Related Translatomic Perturbations in DRD1-Expressing Striatal Cells of Adolescent Male Mice. Genes (Basel). 2026 Jan 25; 17(2).
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Bauer SE, Macrea M, Casey A, Dagli E, Eakin MN, Farber HJ, Gonzalez P, Hayes D, Hu SW, Kathuria H, Knight SL, Moraes TJ, Neptune ER, Piper ME, Skeen EH, Ueng CS, Upson D, Walley SC, Rao DR. Treatment of Nicotine Use in Adolescents Under 18 Years of Age: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2025 Sep; 211(9):1584-1599.
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Aki S, Brown M, Stitzel J, Mathews H. The effects of nicotine on sleep in female C57BL/6J mice. Behav Brain Res. 2025 10 18; 495:115754.
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Gu W, Langlois AWR, Giratallah H, Claw KG, Prasad B, Thummel KE, Tyndale RF. Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme. Pharmacol Res Perspect. 2025 Aug; 13(4):e70149.
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Lombardi AM, Griffioen M, Wong H, Milstead R, Borski C, Shiely E, Bower ME, Schmitt E, LaPlante L, Ehringer MA, Stitzel J, Hoeffer CA. AKT2 Modulates Astrocytic Nicotine Responses In Vivo. Glia. 2025 Oct; 73(10):2098-2129.
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Durra A, Cherry C, Luo C, Hou E, Frauenpreis A, Purkayastha A, Passamano I, Makanani S, Castillo K, Lund A, Choi W, Sen C, Chandran R, Rickabaugh T, Kaushal P, Bouhaddou M, Vladar EK, Gomperts BN. Unflavored electronic cigarette exposure induces alterations in airway ciliary structure and function. Respir Res. 2025 Jul 02; 26(1):223.
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Dennison Himmelfarb CR, Benowitz NL, Blank MD, Bhatnagar A, Chase PJ, Davis EM, Fetterman JL, Keller-Hamilton B, Ogungbe O, Page RL, Rezk-Hanna M, Robertson RM, Whitsel LP. Impact of Smokeless Oral Nicotine Products on Cardiovascular Disease: Implications for Policy, Prevention, and Treatment: A Policy Statement From the American Heart Association. Circulation. 2025 Jan 07; 151(1):e1-e21.
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Williams BM, Steed ND, Woolley JT, Moedl AA, Nelson CA, Jones GC, Burris MD, Arias HR, Kim OH, Jang EY, Hone AJ, McIntosh JM, Yorgason JT, Steffensen SC. Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of a6-Nicotinic Receptors and Dopamine Transporters. ACS Chem Neurosci. 2024 05 01; 15(9):1738-1754.
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Guevara A, Smith CER, Caldwell JL, Ngo L, Mott LR, Lee IJ, Tapa S, Wang Z, Wang L, Woodward WR, Ng GA, Habecker BA, Ripplinger CM. Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart. Am J Physiol Heart Circ Physiol. 2024 06 01; 326(6):H1337-H1349.
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