Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.

Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest. 2011 Nov; 121(11):4548-66.

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subject areas

Animals
Arterioles
Calpain
Cell Proliferation
Collagen Type I
Cysteine Proteinase Inhibitors
Dipeptides
Disease Models, Animal
Epidermal Growth Factor
Familial Primary Pulmonary Hypertension
Gene Knockout Techniques
Humans
Hypertension, Pulmonary
Lung
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Platelet-Derived Growth Factor
Proto-Oncogene Proteins c-sis
Rats
Rats, Sprague-Dawley
RNA, Small Interfering
Smad Proteins
Transforming Growth Factor beta1

authors with profiles

Rubin M Tuder