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Scott Alper

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-8664

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lee FFY, Harris C, Alper S. RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator. J Mol Biol. 2024 04 15; 436(8):168497. PMID: 38369277.
      View in: PubMed
    2. Gurule NJ, Malcolm KC, Harris C, Knapp JR, O'Connor BP, McClendon J, Janssen WJ, Lee FFY, Price C, Osaghae-Nosa J, Wheeler EA, McMahon CM, Pietras EM, Pollyea DA, Alper S. Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis. Leukemia. 2023 10; 37(10):2115-2124. PMID: 37591942.
      View in: PubMed
    3. Grey EL, McClendon J, Suresh J, Alper S, Janssen WJ, Bryant SJ. Thiol-Michael Addition Microparticles: Their Synthesis, Characterization, and Uptake by Macrophages. ACS Biomater Sci Eng. 2023 07 10; 9(7):4223-4240. PMID: 37379254.
      View in: PubMed
    4. Lee FFY, Alper S. Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling. Front Immunol. 2022; 13:1023567. PMID: 36531997.
      View in: PubMed
    5. Saleh LS, Amer LD, Thompson BJ, Danhorn T, Knapp JR, Gibbings SL, Thomas S, Barthel L, O'Connor BP, Janssen WJ, Alper S, Bryant SJ. Mapping Macrophage Polarization and Origin during the Progression of the Foreign Body Response to a Poly(ethylene glycol) Hydrogel Implant. Adv Healthc Mater. 2022 05; 11(9):e2102209. PMID: 34967497.
      View in: PubMed
    6. Pollyea DA, Kim HM, Stevens BM, Lee FF, Harris C, Hedin BR, Knapp JR, O'Connor BP, Jordan CT, Pietras EM, Tan AC, Alper S. MDS-associated SF3B1 mutations enhance proinflammatory gene expression in patient blast cells. J Leukoc Biol. 2021 07; 110(1):197-205. PMID: 33155727.
      View in: PubMed
    7. Lee FF, Davidson K, Harris C, McClendon J, Janssen WJ, Alper S. NF-?B mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages. J Biol Chem. 2020 05 01; 295(18):6236-6248. PMID: 32179652.
      View in: PubMed
    8. Honda JR, Hess T, Carlson R, Kandasamy P, Nieto Ramirez LM, Norton GJ, Virdi R, Islam MN, Mehaffy C, Hasan NA, Epperson LE, Hesser D, Alper S, Strong M, Flores SC, Voelker DR, Dobos KM, Chan ED. Nontuberculous Mycobacteria Show Differential Infectivity and Use Phospholipids to Antagonize LL-37. Am J Respir Cell Mol Biol. 2020 03; 62(3):354-363. PMID: 31545652.
      View in: PubMed
    9. Janssen WJ, Danhorn T, Harris C, Mould KJ, Lee FF, Hedin BR, D'Alessandro A, Leach SM, Alper S. Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages. G3 (Bethesda). 2020 02 06; 10(2):555-567. PMID: 31810980.
      View in: PubMed
    10. Amer LD, Saleh LS, Walker C, Thomas S, Janssen WJ, Alper S, Bryant SJ. Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels. Acta Biomater. 2019 12; 100:105-117. PMID: 31568879.
      View in: PubMed
    11. Pollyea DA, Harris C, Rabe JL, Hedin BR, De Arras L, Katz S, Wheeler E, Bejar R, Walter MJ, Jordan CT, Pietras EM, Alper S. Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling. Haematologica. 2019 09; 104(9):e388-e392. PMID: 30846499.
      View in: PubMed
    12. Alper S, Lenz LL. Editorial overview: Tuning the innate immune response to pathogens. Curr Opin Immunol. 2018 10; 54:vi-ix. PMID: 30342707.
      View in: PubMed
    13. Mubarak RA, Roberts N, Mason RJ, Alper S, Chu HW. Comparison of pro- and anti-inflammatory responses in paired human primary airway epithelial cells and alveolar macrophages. Respir Res. 2018 06 25; 19(1):126. PMID: 29940963.
      View in: PubMed
    14. Honda JR, Alper S, Bai X, Chan ED. Acquired and genetic host susceptibility factors and microbial pathogenic factors that predispose to nontuberculous mycobacterial infections. Curr Opin Immunol. 2018 10; 54:66-73. PMID: 29936307.
      View in: PubMed
    15. Pollyea DA, Hedin BR, O'Connor BP, Alper S. Monocyte function in patients with myelodysplastic syndrome. J Leukoc Biol. 2018 09; 104(3):641-647. PMID: 29656609.
      View in: PubMed
    16. Apfeld J, Alper S. What Can We Learn About Human Disease from the Nematode C. elegans? Methods Mol Biol. 2018; 1706:53-75. PMID: 29423793.
      View in: PubMed
    17. Lee FF, Alper S. Functional Genomics in Murine Macrophages. Methods Mol Biol. 2018; 1809:289-298. PMID: 29987795.
      View in: PubMed
    18. Blumhagen RZ, Hedin BR, Malcolm KC, Burnham EL, Moss M, Abraham E, Huie TJ, Nick JA, Fingerlin TE, Alper S. Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L930-L939. PMID: 28775099.
      View in: PubMed
    19. Alper S, Warg LA, De Arras L, Flatley BR, Davidson EJ, Adams J, Smith K, Wohlford-Lenane CL, McCray PB, Pedersen BS, Schwartz DA, Yang IV. Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria. Genetics. 2016 09; 204(1):327-36. PMID: 27356610.
      View in: PubMed
    20. O'Connor BP, Danhorn T, De Arras L, Flatley BR, Marcus RA, Farias-Hesson E, Leach SM, Alper S. Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex. PLoS Genet. 2015 Feb; 11(2):e1004932. PMID: 25658809.
      View in: PubMed
    21. De Arras L, Guthrie BS, Alper S. Using RNA-interference to investigate the innate immune response in mouse macrophages. J Vis Exp. 2014 Nov 03; (93):e51306. PMID: 25407484.
      View in: PubMed
    22. De Arras L, Laws R, Leach SM, Pontis K, Freedman JH, Schwartz DA, Alper S. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. Genetics. 2014 Jun; 197(2):485-96. PMID: 24361939.
      View in: PubMed
    23. De Arras L, Alper S. Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing. PLoS Genet. 2013 Oct; 9(10):e1003855. PMID: 24204290.
      View in: PubMed
    24. Victorino F, Alper S. Identifying novel spatiotemporal regulators of innate immunity. Immunol Res. 2013 Mar; 55(1-3):3-9. PMID: 22926826.
      View in: PubMed
    25. De Arras L, Seng A, Lackford B, Keikhaee MR, Bowerman B, Freedman JH, Schwartz DA, Alper S. An evolutionarily conserved innate immunity protein interaction network. J Biol Chem. 2013 Jan 18; 288(3):1967-78. PMID: 23209288.
      View in: PubMed
    26. De Arras L, Yang IV, Lackford B, Riches DW, Prekeris R, Freedman JH, Schwartz DA, Alper S. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J Immunol. 2012 Mar 15; 188(6):2905-13. PMID: 22312129.
      View in: PubMed
    27. Yang IV, Jiang W, Rutledge HR, Lackford B, Warg LA, De Arras L, Alper S, Schwartz DA, Pisetsky DS. Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands. Mol Immunol. 2011 Sep; 48(15-16):1886-95. PMID: 21665277.
      View in: PubMed
    28. Yang IV, Alper S, Lackford B, Rutledge H, Warg LA, Burch LH, Schwartz DA. Novel regulators of the systemic response to lipopolysaccharide. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):393-402. PMID: 21131441.
      View in: PubMed
    29. Alper S. Model systems to the rescue: The relationship between aging and innate immunity. Commun Integr Biol. 2010 Sep; 3(5):409-14. PMID: 21057627.
      View in: PubMed
    30. Alper S, McElwee MK, Apfeld J, Lackford B, Freedman JH, Schwartz DA. The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity. J Biol Chem. 2010 Jan 15; 285(3):1822-8. PMID: 19923212.
      View in: PubMed
    31. Yang IV, Wade CM, Kang HM, Alper S, Rutledge H, Lackford B, Eskin E, Daly MJ, Schwartz DA. Identification of novel genes that mediate innate immunity using inbred mice. Genetics. 2009 Dec; 183(4):1535-44. PMID: 19805818.
      View in: PubMed
    32. Green RM, Gally F, Keeney JG, Alper S, Gao B, Han M, Martin RJ, Weinberger AR, Case SR, Minor MN, Chu HW. Impact of cigarette smoke exposure on innate immunity: a Caenorhabditis elegans model. PLoS One. 2009 Aug 31; 4(8):e6860. PMID: 19718433.
      View in: PubMed
    33. Alper S, Laws R, Lackford B, Boyd WA, Dunlap P, Freedman JH, Schwartz DA. Identification of innate immunity genes and pathways using a comparative genomics approach. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):7016-21. PMID: 18463287.
      View in: PubMed
    34. Alper S, Podbilewicz B. Cell fusion in Caenorhabditis elegans. Methods Mol Biol. 2008; 475:53-74. PMID: 18979238.
      View in: PubMed
    35. Alper S, McBride SJ, Lackford B, Freedman JH, Schwartz DA. Specificity and complexity of the Caenorhabditis elegans innate immune response. Mol Cell Biol. 2007 Aug; 27(15):5544-53. PMID: 17526726.
      View in: PubMed
    36. Cui Y, McBride SJ, Boyd WA, Alper S, Freedman JH. Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity. Genome Biol. 2007; 8(6):R122. PMID: 17592649.
      View in: PubMed
    37. Alper S, Kenyon C. The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. Development. 2002 Jul; 129(14):3335-48. PMID: 12091304.
      View in: PubMed
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