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Toni A Nagy

TitleSr Research Associate
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry

    Collapse Research 
    Collapse research activities and funding
    R21AI121474     (DETWEILER, CORRELLA)Jun 1, 2016 - May 31, 2019
    NIH
    Macrophages, Granulomas, and Bacterial Persistence
    Role: Co-Principal Investigator
    F32AI094766     (NAGY, TONI)Mar 15, 2012 - Mar 14, 2015
    NIH
    Role of Host Lipids in Salmonella Replication Within Hemophagocytic Macrophages
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kibby EM, Conte AN, Burroughs AM, Nagy TA, Vargas JA, Whalen LA, Aravind L, Whiteley AT. Bacterial NLR-related proteins protect against phage. Cell. 2023 05 25; 186(11):2410-2424.e18. PMID: 37160116.
      View in: PubMed
    2. Villanueva JA, Crooks AL, Nagy TA, Quintana JLJ, Dalebroux ZD, Detweiler CS. Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes. mBio. 2022 10 26; 13(5):e0179022. PMID: 36135367.
      View in: PubMed
    3. Dombach JL, Quintana JL, Allgood SC, Nagy TA, Gustafson DL, Detweiler CS. A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice. PLoS Pathog. 2022 06; 18(6):e1010606. PMID: 35687608.
      View in: PubMed
    4. Dombach JL, Quintana JLJ, Nagy TA, Wan C, Crooks AL, Yu H, Su CC, Yu EW, Shen J, Detweiler CS. A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids. PLoS Pathog. 2020 12; 16(12):e1009119. PMID: 33290418.
      View in: PubMed
    5. Nagy TA, Crooks AL, Quintana JLJ, Detweiler CS. Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice. ACS Infect Dis. 2020 05 08; 6(5):1238-1249. PMID: 32272013.
      View in: PubMed
    6. Reens AL, Nagy TA, Detweiler CS. Salmonella enterica Requires Lipid Metabolism Genes To Replicate in Proinflammatory Macrophages and Mice. Infect Immun. 2019 12 17; 88(1). PMID: 31611277.
      View in: PubMed
    7. Nagy TA, Quintana JLJ, Reens AL, Crooks AL, Detweiler CS. Autophagy Induction by a Small Molecule Inhibits Salmonella Survival in Macrophages and Mice. Antimicrob Agents Chemother. 2019 09 09; 63(12). PMID: 31591121.
      View in: PubMed
    8. Reens AL, Crooks AL, Su CC, Nagy TA, Reens DL, Podoll JD, Edwards ME, Yu EW, Detweiler CS. A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load. PLoS Pathog. 2018 06; 14(6):e1007115. PMID: 29879224.
      View in: PubMed
    9. Courtney CM, Goodman SM, Nagy TA, Levy M, Bhusal P, Madinger NE, Detweiler CS, Nagpal P, Chatterjee A. Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation. Sci Adv. 2017 10; 3(10):e1701776. PMID: 28983513.
      View in: PubMed
    10. Bauler TJ, Starr T, Nagy TA, Sridhar S, Scott D, Winkler CW, Steele-Mortimer O, Detweiler CS, Peterson KE. Salmonella Meningitis Associated with Monocyte Infiltration in Mice. Am J Pathol. 2017 Jan; 187(1):187-199. PMID: 27955815.
      View in: PubMed
    11. Brown DE, Nick HJ, McCoy MW, Moreland SM, Stepanek AM, Benik R, O'Connell KE, Pilonieta MC, Nagy TA, Detweiler CS. Increased ferroportin-1 expression and rapid splenic iron loss occur with anemia caused by Salmonella enterica Serovar Typhimurium infection in mice. Infect Immun. 2015 Jun; 83(6):2290-9. PMID: 25824831.
      View in: PubMed
    12. Nagy TA, Moreland SM, Detweiler CS. Salmonella acquires ferrous iron from haemophagocytic macrophages. Mol Microbiol. 2014 Sep; 93(6):1314-26. PMID: 25081030.
      View in: PubMed
    13. Nagy TA, Moreland SM, Andrews-Polymenis H, Detweiler CS. The ferric enterobactin transporter Fep is required for persistent Salmonella enterica serovar typhimurium infection. Infect Immun. 2013 Nov; 81(11):4063-70. PMID: 23959718.
      View in: PubMed
    14. Pilonieta MC, Nagy TA, Jorgensen DR, Detweiler CS. A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production. Mol Microbiol. 2012 Apr; 84(2):296-309. PMID: 22375627.
      View in: PubMed
    15. Nagy TA, Wroblewski LE, Wang D, Piazuelo MB, Delgado A, Romero-Gallo J, Noto J, Israel DA, Ogden SR, Correa P, Cover TL, Peek RM. ?-Catenin and p120 mediate PPARd-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology. 2011 Aug; 141(2):553-64. PMID: 21704622.
      View in: PubMed
    16. Nagy TA, Allen SS, Wroblewski LE, Flaherty DK, Slaughter JC, Perez-Perez G, Israel DA, Peek RM. Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions. Am J Pathol. 2011 Apr; 178(4):1448-52. PMID: 21406172.
      View in: PubMed
    17. Wei J, Nagy TA, Vilgelm A, Zaika E, Ogden SR, Romero-Gallo J, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A. Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology. 2010 Oct; 139(4):1333-43. PMID: 20547161.
      View in: PubMed
    18. Franco AT, Friedman DB, Nagy TA, Romero-Gallo J, Krishna U, Kendall A, Israel DA, Tegtmeyer N, Washington MK, Peek RM. Delineation of a carcinogenic Helicobacter pylori proteome. Mol Cell Proteomics. 2009 Aug; 8(8):1947-58. PMID: 19470446.
      View in: PubMed
    19. Nagy TA, Frey MR, Yan F, Israel DA, Polk DB, Peek RM. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis. 2009 Mar 01; 199(5):641-51. PMID: 19199544.
      View in: PubMed
    20. Franco AT, Johnston E, Krishna U, Yamaoka Y, Israel DA, Nagy TA, Wroblewski LE, Piazuelo MB, Correa P, Peek RM. Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res. 2008 Jan 15; 68(2):379-87. PMID: 18199531.
      View in: PubMed
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