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Breck A. Duerkop

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-8670

    Collapse Research 
    Collapse research activities and funding
    R01AI141479     (DUERKOP, BRECK A)Sep 14, 2018 - Aug 31, 2023
    NIH
    Mechanistic basis of bacteriophages for the decolonization of vancomycin resistant enterococci in the intestine.
    Role: Principal Investigator
    K01DK102436     (DUERKOP, BRECK A)Sep 15, 2014 - Aug 31, 2019
    NIH
    The contribution of bacteriophages to host-microbe interactions in the intestine
    Role: Principal Investigator
    F32DK089718     (DUERKOP, BRECK A)Jul 1, 2010 - Jun 30, 2013
    NIH
    Interactions of a commensal bacterium with the intestinal mucosal surface
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kirsch JM, Hryckowian AJ, Duerkop BA. A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota. bioRxiv. 2024 Mar 09. PMID: 37873088.
      View in: PubMed
    2. Johnson CN, Bullen NP, Andersen SE, Arya G, Marotta SR, Whitney JC, Duerkop BA. Evolution of a small phage protein overcomes antiphage defense in Enterococcus faecalis. bioRxiv. 2023 Dec 02. PMID: 38014348.
      View in: PubMed
    3. Kirsch JM, Ely S, Stellfox ME, Hullahalli K, Luong P, Palmer KL, Van Tyne D, Duerkop BA. Targeted IS-element sequencing uncovers transposition dynamics during selective pressure in enterococci. PLoS Pathog. 2023 06; 19(6):e1011424. PMID: 37267422.
      View in: PubMed
    4. Colbert JF, Kirsch JM, Erzen CL, Langou?t-Astri? CJ, Thompson GE, McMurtry SA, Kofonow JM, Robertson CE, Kovacs EJ, Sullivan RC, Hippensteel JA, Sawant NV, De Nisco NJ, McCollister BD, Schwartz RS, Horswill AR, Frank DN, Duerkop BA, Schmidt EP. Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity. mBio. 2023 06 27; 14(3):e0005223. PMID: 37102874.
      View in: PubMed
    5. Colbert JF, Kirsch JM, Erzen CL, Langou?t-Astri? CJ, Thompson GE, McMurtry SA, Kofonow JM, Robertson CE, Kovacs EJ, Sullivan RC, Hippensteel JA, Sawant NV, De Nisco NJ, McCollister BD, Schwartz RS, Horswill AR, Frank DN, Duerkop BA, Schmidt EP. Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity. bioRxiv. 2023 Jan 11. PMID: 36711447.
      View in: PubMed
    6. Mangalea MR, Keift K, Duerkop BA, Anantharaman K. Assembly and Annotation of Viral Metagenomes from Short-Read Sequencing Data. Methods Mol Biol. 2023; 2649:317-337. PMID: 37258871.
      View in: PubMed
    7. Kunz Coyne AJ, Stamper K, Kebriaei R, Holger DJ, El Ghali A, Morrisette T, Biswas B, Wilson M, Deschenes MV, Canfield GS, Duerkop BA, Arias CA, Rybak MJ. Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage Susceptibility. Antibiotics (Basel). 2022 Aug 30; 11(9). PMID: 36139953.
      View in: PubMed
    8. Johnson CN, Palacios Araya D, Schink V, Islam M, Mangalea MR, Decurtis EK, Ngo TC, Palmer KL, Duerkop BA. Genetically distant bacteriophages select for unique genomic changes in Enterococcus faecalis. Microbiologyopen. 2022 04; 11(2):e1273. PMID: 35478284.
      View in: PubMed
    9. Lev K, Kunz Coyne AJ, Kebriaei R, Morrisette T, Stamper K, Holger DJ, Canfield GS, Duerkop BA, Arias CA, Rybak MJ. Evaluation of Bacteriophage-Antibiotic Combination Therapy for Biofilm-Embedded MDR Enterococcus faecium. Antibiotics (Basel). 2022 Mar 15; 11(3). PMID: 35326855.
      View in: PubMed
    10. Araya DP, Palmer KL, Duerkop BA. Correction: CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria. PLoS Pathog. 2021 Dec; 17(12):e1010153. PMID: 34898641.
      View in: PubMed
    11. Morrisette T, Lev KL, Canfield GS, Duerkop BA, Kebriaei R, Stamper KC, Holger D, Lehman SM, Willcox S, Arias CA, Rybak MJ. Evaluation of Bacteriophage Cocktails Alone and in Combination with Daptomycin against Daptomycin-Nonsusceptible Enterococcus faecium. Antimicrob Agents Chemother. 2022 01 18; 66(1):e0162321. PMID: 34723631.
      View in: PubMed
    12. Johnson CN, Sheriff EK, Duerkop BA, Chatterjee A. Let Me Upgrade You: Impact of Mobile Genetic Elements on Enterococcal Adaptation and Evolution. J Bacteriol. 2021 10 12; 203(21):e0017721. PMID: 34370561.
      View in: PubMed
    13. Kirsch JM, Brzozowski RS, Faith D, Round JL, Secor PR, Duerkop BA. Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals. Annu Rev Virol. 2021 09 29; 8(1):95-113. PMID: 34255542.
      View in: PubMed
    14. Palacios Araya D, Palmer KL, Duerkop BA. CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria. PLoS Pathog. 2021 07; 17(7):e1009672. PMID: 34237097.
      View in: PubMed
    15. Mangalea MR, Paez-Espino D, Kieft K, Chatterjee A, Chriswell ME, Seifert JA, Feser ML, Demoruelle MK, Sakatos A, Anantharaman K, Deane KD, Kuhn KA, Holers VM, Duerkop BA. Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential. Cell Host Microbe. 2021 05 12; 29(5):726-739.e5. PMID: 33957082.
      View in: PubMed
    16. Canfield GS, Chatterjee A, Espinosa J, Mangalea MR, Sheriff EK, Keidan M, McBride SW, McCollister BD, Hang HC, Duerkop BA. Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium. Antimicrob Agents Chemother. 2023 05 01; 65(5). PMID: 33649110.
      View in: PubMed
    17. Spencer BL, Chatterjee A, Duerkop BA, Baker CJ, Doran KS. Complete Genome Sequence of Neonatal Clinical Group B Streptococcal Isolate CJB111. Microbiol Resour Announc. 2021 Jan 14; 10(2). PMID: 33446593.
      View in: PubMed
    18. Chatterjee A, Willett JLE, Dunny GM, Duerkop BA. Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria. PLoS Genet. 2021 01; 17(1):e1009204. PMID: 33411815.
      View in: PubMed
    19. Kleiner M, Bushnell B, Sanderson KE, Hooper LV, Duerkop BA. Transductomics: sequencing-based detection and analysis of transduced DNA in pure cultures and microbial communities. Microbiome. 2020 11 15; 8(1):158. PMID: 33190645.
      View in: PubMed
    20. Alhajjar N, Chatterjee A, Spencer BL, Burcham LR, Willett JLE, Dunny GM, Duerkop BA, Doran KS. Genome-Wide Mutagenesis Identifies Factors Involved in Enterococcus faecalis Vaginal Adherence and Persistence. Infect Immun. 2020 09 18; 88(10). PMID: 32778611.
      View in: PubMed
    21. Morrisette T, Lev KL, Kebriaei R, Abdul-Mutakabbir JC, Stamper KC, Morales S, Lehman SM, Canfield GS, Duerkop BA, Arias CA, Rybak MJ. Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities. Antimicrob Agents Chemother. 2020 08 20; 64(9). PMID: 32571816.
      View in: PubMed
    22. Canfield GS, Duerkop BA. Molecular mechanisms of enterococcal-bacteriophage interactions and implications for human health. Curr Opin Microbiol. 2020 08; 56:38-44. PMID: 32652484.
      View in: PubMed
    23. Mangalea MR, Duerkop BA. Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies. Infect Immun. 2020 06 22; 88(7). PMID: 32094257.
      View in: PubMed
    24. Chatterjee A, Willett JLE, Nguyen UT, Monogue B, Palmer KL, Dunny GM, Duerkop BA. Parallel Genomics Uncover Novel Enterococcal-Bacteriophage Interactions. mBio. 2020 03 03; 11(2). PMID: 32127456.
      View in: PubMed
    25. Johnson CN, Duerkop BA. Dyeing to connect. Nat Microbiol. 2019 12; 4(12):2033-2034. PMID: 31754272.
      View in: PubMed
    26. Rodrigues M, McBride SW, Hullahalli K, Palmer KL, Duerkop BA. Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci. Antimicrob Agents Chemother. 2019 11; 63(11). PMID: 31527030.
      View in: PubMed
    27. Price VJ, McBride SW, Hullahalli K, Chatterjee A, Duerkop BA, Palmer KL. Enterococcus faecalis CRISPR-Cas Is a Robust Barrier to Conjugative Antibiotic Resistance Dissemination in the Murine Intestine. mSphere. 2019 07 24; 4(4). PMID: 31341074.
      View in: PubMed
    28. Chatterjee A, Johnson CN, Luong P, Hullahalli K, McBride SW, Schubert AM, Palmer KL, Carlson PE, Duerkop BA. Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci. Infect Immun. 2019 06; 87(6). PMID: 30936157.
      View in: PubMed
    29. Chatterjee A, Duerkop BA. Sugar and Fatty Acids Ack-celerate Prophage Induction. Cell Host Microbe. 2019 02 13; 25(2):175-176. PMID: 30763529.
      View in: PubMed
    30. Duerkop BA. Bacteriophages shift the focus of the mammalian microbiota. PLoS Pathog. 2018 10; 14(10):e1007310. PMID: 30359456.
      View in: PubMed
    31. Duerkop BA, Kleiner M, Paez-Espino D, Zhu W, Bushnell B, Hassell B, Winter SE, Kyrpides NC, Hooper LV. Murine colitis reveals a disease-associated bacteriophage community. Nat Microbiol. 2018 09; 3(9):1023-1031. PMID: 30038310.
      View in: PubMed
    32. Chatterjee A, Duerkop BA. Beyond Bacteria: Bacteriophage-Eukaryotic Host Interactions Reveal Emerging Paradigms of Health and Disease. Front Microbiol. 2018; 9:1394. PMID: 29997604.
      View in: PubMed
    33. Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, B?ttner L, de Lima Rom?o E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, T?kel ?, Koh AY, Burstein E, Hooper LV, B?umler AJ, Winter SE. Precision editing of the gut microbiota ameliorates colitis. Nature. 2018 01 11; 553(7687):208-211. PMID: 29323293.
      View in: PubMed
    34. Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, B?ttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE. Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis. Cell Host Microbe. 2017 Feb 08; 21(2):208-219. PMID: 28182951.
      View in: PubMed
    35. Duerkop BA, Huo W, Bhardwaj P, Palmer KL, Hooper LV. Molecular Basis for Lytic Bacteriophage Resistance in Enterococci. mBio. 2016 08 30; 7(4). PMID: 27578757.
      View in: PubMed
    36. Kleiner M, Hooper LV, Duerkop BA. Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes. BMC Genomics. 2015 Jan 22; 16:7. PMID: 25608871.
      View in: PubMed
    37. Duerkop BA, Hooper LV. Resident viruses and their interactions with the immune system. Nat Immunol. 2013 Jul; 14(7):654-9. PMID: 23778792.
      View in: PubMed
    38. Duerkop BA, Clements CV, Rollins D, Rodrigues JL, Hooper LV. A composite bacteriophage alters colonization by an intestinal commensal bacterium. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17621-6. PMID: 23045666.
      View in: PubMed
    39. McClean AE, Duerkop BA, Greenberg EP, Kluepfel DA. AHL signals induce rubrifacine production in a bruI mutant of Brenneria rubrifaciens. Phytopathology. 2012 Feb; 102(2):195-203. PMID: 22236075.
      View in: PubMed
    40. Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J. Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Org Lett. 2010 Feb 19; 12(4):716-9. PMID: 20095633.
      View in: PubMed
    41. Duerkop BA, Vaishnava S, Hooper LV. Immune responses to the microbiota at the intestinal mucosal surface. Immunity. 2009 Sep 18; 31(3):368-76. PMID: 19766080.
      View in: PubMed
    42. Chandler JR, Duerkop BA, Hinz A, West TE, Herman JP, Churchill ME, Skerrett SJ, Greenberg EP. Mutational analysis of Burkholderia thailandensis quorum sensing and self-aggregation. J Bacteriol. 2009 Oct; 191(19):5901-9. PMID: 19648250.
      View in: PubMed
    43. Duerkop BA, Varga J, Chandler JR, Peterson SB, Herman JP, Churchill ME, Parsek MR, Nierman WC, Greenberg EP. Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis. J Bacteriol. 2009 Jun; 191(12):3909-18. PMID: 19376863.
      View in: PubMed
    44. Duerkop BA, Herman JP, Ulrich RL, Churchill ME, Greenberg EP. The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone. J Bacteriol. 2008 Jul; 190(14):5137-41. PMID: 18487338.
      View in: PubMed
    45. Duerkop BA, Ulrich RL, Greenberg EP. Octanoyl-homoserine lactone is the cognate signal for Burkholderia mallei BmaR1-BmaI1 quorum sensing. J Bacteriol. 2007 Jul; 189(14):5034-40. PMID: 17496085.
      View in: PubMed
    46. Chang HK, Thalhofer C, Duerkop BA, Mehling JS, Verma S, Gollob KJ, Almeida R, Wilson ME. Oxidant generation by single infected monocytes after short-term fluorescence labeling of a protozoan parasite. Infect Immun. 2007 Feb; 75(2):1017-24. PMID: 17118986.
      View in: PubMed
    47. M?h U, Hare BJ, Duerkop BA, Schuster M, Hanzelka BL, Heim R, Olson ER, Greenberg EP. A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16948-52. PMID: 17075036.
      View in: PubMed
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