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Corrella Scott Detweiler

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/735-2956

    Collapse Research 
    Collapse research activities and funding
    R01AI168916     (DETWEILER, CORRELLA S)Aug 7, 2023 - Jul 31, 2027
    NIH
    Infection-Dependent Vulnerabilities of Gram-negative Bacterial Pathogens
    Role: Principal Investigator
    R21AI171945     (DETWEILER, CORRELLA S)Mar 1, 2023 - Feb 28, 2025
    NIH
    Using Salmonella Pathogenesis and Cell Biology as a Discovery Tool
    Role: Principal Investigator
    R21AI151979     (DETWEILER, CORRELLA S)Dec 7, 2020 - Nov 30, 2023
    NIH
    A Small Molecule That Blocks Salmonella Replication in Macrophages
    Role: Principal Investigator
    R21AI126453     (DETWEILER, CORRELLA)Jun 15, 2016 - May 31, 2019
    NIH
    Chemical Probes for Bacteria-Macrophage Interactions
    Role: Principal Investigator
    R21AI121474     (DETWEILER, CORRELLA)Jun 1, 2016 - May 31, 2019
    NIH
    Macrophages, Granulomas, and Bacterial Persistence
    Role: Principal Investigator
    R33AI121365     (DETWEILER, CORRELLA)Dec 1, 2015 - Nov 30, 2021
    NIH
    A Novel Screen for Antibacterials that Are Non-Toxic to Mammals
    Role: Principal Investigator
    R21AI121365     (DETWEILER, CORRELLA)Dec 1, 2015 - Nov 30, 2017
    NIH
    A Novel Screen for Antibacterials that Are Non-Toxic to Mammals
    Role: Principal Investigator
    R01AI095395     (DETWEILER, CORRELLA)Mar 1, 2012 - Feb 28, 2018
    NIH
    Hemophagocytic Macrophages and Systemic Salmonella Infection
    Role: Principal Investigator
    R21AI099593     (DETWEILER, CORRELLA)Feb 15, 2012 - Jan 31, 2015
    NIH
    Host Pathways that Enable /Salmonella/ Replication Within Hemophagocytic Macropha
    Role: Principal Investigator
    R56AI095395     (DETWEILER, CORRELLA)Sep 1, 2011 - Feb 29, 2012
    NIH
    Hemophagocytic Macrophages and Systemic Salmonella Infection
    Role: Principal Investigator
    R21AI076682     (DETWEILER, CORRELLA)Dec 15, 2007 - Nov 30, 2010
    NIH
    A Mammalian Cellular Niche for Chronic Bacteria
    Role: Principal Investigator
    R01AI072492     (DETWEILER, CORRELLA)Jun 1, 2007 - Dec 31, 2013
    NIH
    Persistent Systemic Infection of Mice by Salmonella Enterica
    Role: Principal Investigator
    R56AI063116     (DETWEILER, CORRELLA)Sep 1, 2005 - Aug 31, 2007
    NIH
    The Salmonella RcsC Phosphorelay System and Virulence
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Allgood SC, Su C-C, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS. Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment. mBio. 2023 Dec 19; 14(6):e0249223. PMID: 37921493.
      View in: PubMed
    2. Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS. Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment. bioRxiv. 2023 Sep 20. PMID: 37786697.
      View in: PubMed
    3. Villanueva JA, Crooks AL, Nagy TA, Quintana JLJ, Dalebroux ZD, Detweiler CS. Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes. mBio. 2022 10 26; 13(5):e0179022. PMID: 36135367.
      View in: PubMed
    4. Dombach JL, Quintana JL, Allgood SC, Nagy TA, Gustafson DL, Detweiler CS. A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice. PLoS Pathog. 2022 06; 18(6):e1010606. PMID: 35687608.
      View in: PubMed
    5. Dombach JL, Quintana JLJ, Detweiler CS. Staphylococcal Bacterial Persister Cells, Biofilms, and Intracellular Infection Are Disrupted by JD1, a Membrane-Damaging Small Molecule. mBio. 2021 10 26; 12(5):e0180121. PMID: 34634935.
      View in: PubMed
    6. McLeod JR, Harvey PA, Detweiler CS. An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice. Microbiol Spectr. 2021 09 03; 9(1):e0027521. PMID: 34190602.
      View in: PubMed
    7. Dombach JL, Quintana JLJ, Nagy TA, Wan C, Crooks AL, Yu H, Su CC, Yu EW, Shen J, Detweiler CS. A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids. PLoS Pathog. 2020 12; 16(12):e1009119. PMID: 33290418.
      View in: PubMed
    8. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. J Virol. 2020 09 29; 94(20). PMID: 32737250.
      View in: PubMed
    9. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. J Clin Microbiol. 2020 09 22; 58(10). PMID: 32737123.
      View in: PubMed
    10. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. Antimicrob Agents Chemother. 2020 09 21; 64(10). PMID: 32737055.
      View in: PubMed
    11. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. Infect Immun. 2020 09 18; 88(10). PMID: 32737060.
      View in: PubMed
    12. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. Mol Cell Biol. 2020 09 14; 40(19). PMID: 32737077.
      View in: PubMed
    13. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. J Bacteriol. 2020 09 08; 202(19). PMID: 32737061.
      View in: PubMed
    14. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. Appl Environ Microbiol. 2020 09 01; 86(18). PMID: 32737128.
      View in: PubMed
    15. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. mBio. 2020 07 31; 11(4). PMID: 32737071.
      View in: PubMed
    16. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. Microbiol Mol Biol Rev. 2020 08 19; 84(3). PMID: 32737075.
      View in: PubMed
    17. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. Clin Microbiol Rev. 2020 09 16; 33(4). PMID: 32737035.
      View in: PubMed
    18. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. mSystems. 2020 Jul 31; 5(4). PMID: 32737195.
      View in: PubMed
    19. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. mSphere. 2020 07 31; 5(4). PMID: 32737154.
      View in: PubMed
    20. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky MJ, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. Microbiol Resour Announc. 2020 Jul 31; 9(32). PMID: 32737059.
      View in: PubMed
    21. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky M, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Fuller AO, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. J Microbiol Biol Educ. 2020; 21(2). PMID: 32788948.
      View in: PubMed
    22. Schloss PD, Junior M, Alvania R, Arias CA, Baumler A, Casadevall A, Detweiler C, Drake H, Gilbert J, Imperiale MJ, Lovett S, Maloy S, McAdam AJ, Newton ILG, Sadowsky M, Sandri-Goldin RM, Silhavy TJ, Tontonoz P, Young JH, Cameron CE, Cann I, Oveta Fuller A, Kozik AJ. The ASM Journals Committee Values the Contributions of Black Microbiologists. Microbiol Spectr. 2020 07; 8(3). PMID: 32737963.
      View in: PubMed
    23. Nagy TA, Crooks AL, Quintana JLJ, Detweiler CS. Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice. ACS Infect Dis. 2020 05 08; 6(5):1238-1249. PMID: 32272013.
      View in: PubMed
    24. Detweiler CS. Infection-based chemical screens uncover host-pathogen interactions. Curr Opin Microbiol. 2020 04; 54:43-50. PMID: 32036306.
      View in: PubMed
    25. Reens AL, Nagy TA, Detweiler CS. Salmonella enterica Requires Lipid Metabolism Genes To Replicate in Proinflammatory Macrophages and Mice. Infect Immun. 2019 12 17; 88(1). PMID: 31611277.
      View in: PubMed
    26. Nagy TA, Quintana JLJ, Reens AL, Crooks AL, Detweiler CS. Autophagy Induction by a Small Molecule Inhibits Salmonella Survival in Macrophages and Mice. Antimicrob Agents Chemother. 2019 09 09; 63(12). PMID: 31591121.
      View in: PubMed
    27. Reens AL, Crooks AL, Su CC, Nagy TA, Reens DL, Podoll JD, Edwards ME, Yu EW, Detweiler CS. A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load. PLoS Pathog. 2018 06; 14(6):e1007115. PMID: 29879224.
      View in: PubMed
    28. Lathrop SK, Cooper KG, Binder KA, Starr T, Mampilli V, Detweiler CS, Steele-Mortimer O. Salmonella Typhimurium Infection of Human Monocyte-Derived Macrophages. Curr Protoc Microbiol. 2018 08; 50(1):e56. PMID: 29927091.
      View in: PubMed
    29. Courtney CM, Goodman SM, Nagy TA, Levy M, Bhusal P, Madinger NE, Detweiler CS, Nagpal P, Chatterjee A. Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation. Sci Adv. 2017 10; 3(10):e1701776. PMID: 28983513.
      View in: PubMed
    30. Detweiler CS. A New Way to Beat Intestinal Pathogens. Trends Microbiol. 2017 03; 25(3):169-170. PMID: 28139374.
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    31. Bauler TJ, Starr T, Nagy TA, Sridhar S, Scott D, Winkler CW, Steele-Mortimer O, Detweiler CS, Peterson KE. Salmonella Meningitis Associated with Monocyte Infiltration in Mice. Am J Pathol. 2017 Jan; 187(1):187-199. PMID: 27955815.
      View in: PubMed
    32. McQuate SE, Young AM, Silva-Herzog E, Bunker E, Hernandez M, de Chaumont F, Liu X, Detweiler CS, Palmer AE. Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA. Cell Microbiol. 2017 01; 19(1). PMID: 27376507.
      View in: PubMed
    33. Silva-Herzog E, McDonald EM, Crooks AL, Detweiler CS. Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses. PLoS One. 2015; 10(12):e0141343. PMID: 26633172.
      View in: PubMed
    34. McDonald EM, Pilonieta MC, Nick HJ, Detweiler CS. Bacterial Stimulation of Toll-Like Receptor 4 Drives Macrophages To Hemophagocytose. Infect Immun. 2016 01; 84(1):47-55. PMID: 26459510.
      View in: PubMed
    35. Brown DE, Nick HJ, McCoy MW, Moreland SM, Stepanek AM, Benik R, O'Connell KE, Pilonieta MC, Nagy TA, Detweiler CS. Increased ferroportin-1 expression and rapid splenic iron loss occur with anemia caused by Salmonella enterica Serovar Typhimurium infection in mice. Infect Immun. 2015 Jun; 83(6):2290-9. PMID: 25824831.
      View in: PubMed
    36. Teske SS, Detweiler CS. The biomechanisms of metal and metal-oxide nanoparticles' interactions with cells. Int J Environ Res Public Health. 2015 Jan 22; 12(2):1112-34. PMID: 25648173.
      View in: PubMed
    37. Pilonieta MC, Moreland SM, English CN, Detweiler CS. Salmonella enterica infection stimulates macrophages to hemophagocytose. mBio. 2014 Dec 09; 5(6):e02211. PMID: 25491357.
      View in: PubMed
    38. Nagy TA, Moreland SM, Detweiler CS. Salmonella acquires ferrous iron from haemophagocytic macrophages. Mol Microbiol. 2014 Sep; 93(6):1314-26. PMID: 25081030.
      View in: PubMed
    39. Nagy TA, Moreland SM, Andrews-Polymenis H, Detweiler CS. The ferric enterobactin transporter Fep is required for persistent Salmonella enterica serovar typhimurium infection. Infect Immun. 2013 Nov; 81(11):4063-70. PMID: 23959718.
      View in: PubMed
    40. Brown DE, Libby SJ, Moreland SM, McCoy MW, Brabb T, Stepanek A, Fang FC, Detweiler CS. Salmonella enterica causes more severe inflammatory disease in C57/BL6 Nramp1G169 mice than Sv129S6 mice. Vet Pathol. 2013 Sep; 50(5):867-76. PMID: 23446432.
      View in: PubMed
    41. McCoy MW, Moreland SM, Detweiler CS. Hemophagocytic macrophages in murine typhoid fever have an anti-inflammatory phenotype. Infect Immun. 2012 Oct; 80(10):3642-9. PMID: 22868497.
      View in: PubMed
    42. Pilonieta MC, Nagy TA, Jorgensen DR, Detweiler CS. A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production. Mol Microbiol. 2012 Apr; 84(2):296-309. PMID: 22375627.
      View in: PubMed
    43. Silva-Herzog E, Detweiler CS. Salmonella enterica replication in hemophagocytic macrophages requires two type three secretion systems. Infect Immun. 2010 Aug; 78(8):3369-77. PMID: 20515933.
      View in: PubMed
    44. Brown DE, McCoy MW, Pilonieta MC, Nix RN, Detweiler CS. Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis. PLoS One. 2010 Feb 26; 5(2):e9441. PMID: 20195482.
      View in: PubMed
    45. Pilonieta MC, Erickson KD, Ernst RK, Detweiler CS. A protein important for antimicrobial peptide resistance, YdeI/OmdA, is in the periplasm and interacts with OmpD/NmpC. J Bacteriol. 2009 Dec; 191(23):7243-52. PMID: 19767429.
      View in: PubMed
    46. Silva-Herzog E, Detweiler CS. Intracellular microbes and haemophagocytosis. Cell Microbiol. 2008 Nov; 10(11):2151-8. PMID: 18616693.
      View in: PubMed
    47. Nix RN, Altschuler SE, Henson PM, Detweiler CS. Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. PLoS Pathog. 2007 Dec; 3(12):e193. PMID: 18085823.
      View in: PubMed
    48. Karimpour-Fard A, Detweiler CS, Erickson KD, Hunter L, Gill RT. Cross-species cluster co-conservation: a new method for generating protein interaction networks. Genome Biol. 2007; 8(9):R185. PMID: 17803817.
      View in: PubMed
    49. Erickson KD, Detweiler CS. The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice. Mol Microbiol. 2006 Nov; 62(3):883-94. PMID: 17010160.
      View in: PubMed
    50. De Keersmaecker SC, Marchal K, Verhoeven TL, Engelen K, Vanderleyden J, Detweiler CS. Microarray analysis and motif detection reveal new targets of the Salmonella enterica serovar Typhimurium HilA regulatory protein, including hilA itself. J Bacteriol. 2005 Jul; 187(13):4381-91. PMID: 15968047.
      View in: PubMed
    51. Detweiler CS, Monack DM, Brodsky IE, Mathew H, Falkow S. virK, somA and rcsC are important for systemic Salmonella enterica serovar Typhimurium infection and cationic peptide resistance. Mol Microbiol. 2003 Apr; 48(2):385-400. PMID: 12675799.
      View in: PubMed
    52. Chan K, Baker S, Kim CC, Detweiler CS, Dougan G, Falkow S. Genomic comparison of Salmonella enterica serovars and Salmonella bongori by use of an S. enterica serovar typhimurium DNA microarray. J Bacteriol. 2003 Jan; 185(2):553-63. PMID: 12511502.
      View in: PubMed
    53. Monack DM, Detweiler CS, Falkow S. Salmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1. Cell Microbiol. 2001 Dec; 3(12):825-37. PMID: 11736994.
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    54. Detweiler CS, Cunanan DB, Falkow S. Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5850-5. PMID: 11320214.
      View in: PubMed
    55. Lee AK, Detweiler CS, Falkow S. OmpR regulates the two-component system SsrA-ssrB in Salmonella pathogenicity island 2. J Bacteriol. 2000 Feb; 182(3):771-81. PMID: 10633113.
      View in: PubMed
    56. Owens JC, Detweiler CS, Li JJ. CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12521-6. PMID: 9356482.
      View in: PubMed
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