 Focal Adhesion Kinase 1
"Focal Adhesion Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
| Descriptor ID |
D051417
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| MeSH Number(s) |
D08.811.913.696.620.682.725.049.500 D12.776.744.493
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| Concept/Terms |
Focal Adhesion Kinase 1- Focal Adhesion Kinase 1
- Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
- Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
- p125FAK Protein
- Protein Tyrosine Kinase 2
- Endogenous Substrate pp120
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Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 1".
This graph shows the total number of publications written about "Focal Adhesion Kinase 1" by people in this website by year, and whether "Focal Adhesion Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2003 | 0 | 4 | 4 | | 2006 | 0 | 1 | 1 | | 2009 | 0 | 2 | 2 | | 2011 | 1 | 1 | 2 | | 2012 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Focal Adhesion Kinase 1" by people in Profiles.
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Kessler BE, Mishall KM, Kellett MD, Clark EG, Pugazhenthi U, Pozdeyev N, Kim J, Tan AC, Schweppe RE. Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. Oncogene. 2019 04; 38(14):2565-2579.
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Shtam T, Naryzhny S, Samsonov R, Karasik D, Mizgirev I, Kopylov A, Petrenko E, Zabrodskaya Y, Kamyshinsky R, Nikitin D, Sorokin M, Buzdin A, Gil-Henn H, Malek A. Plasma exosomes stimulate breast cancer metastasis through surface interactions and activation of FAK signaling. Breast Cancer Res Treat. 2019 Feb; 174(1):129-141.
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Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U. Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart. J Cell Biochem. 2017 09; 118(9):2933-2940.
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Kessler BE, Sharma V, Zhou Q, Jing X, Pike LA, Kerege AA, Sams SB, Schweppe RE. FAK Expression, Not Kinase Activity, Is a Key Mediator of Thyroid Tumorigenesis and Protumorigenic Processes. Mol Cancer Res. 2016 09; 14(9):869-82.
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Chatterji T, Varkaris AS, Parikh NU, Song JH, Cheng CJ, Schweppe RE, Alexander S, Davis JW, Troncoso P, Friedl P, Kuang J, Lin SH, Gallick GE. Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells. Oncotarget. 2015 Apr 30; 6(12):10175-94.
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Whitson RJ, Lucia MS, Lambert JR. Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2). J Cell Biochem. 2013 Jun; 114(6):1424-33.
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Chan CM, Jing X, Pike LA, Zhou Q, Lim DJ, Sams SB, Lund GS, Sharma V, Haugen BR, Schweppe RE. Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis. Clin Cancer Res. 2012 Jul 01; 18(13):3580-91.
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Infante JR, Camidge DR, Mileshkin LR, Chen EX, Hicks RJ, Rischin D, Fingert H, Pierce KJ, Xu H, Roberts WG, Shreeve SM, Burris HA, Siu LL. Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors. J Clin Oncol. 2012 May 01; 30(13):1527-33.
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Heinhuis B, Koenders MI, van den Berg WB, Netea MG, Dinarello CA, Joosten LA. Interleukin 32 (IL-32) contains a typical a-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1. J Biol Chem. 2012 Feb 17; 287(8):5733-43.
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McConnell BV, Koto K, Gutierrez-Hartmann A. Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression. Mol Cancer. 2011 Jun 18; 10:75.
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