 Choline
"Choline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
| Descriptor ID |
D002794
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| MeSH Number(s) |
D02.033.100.291.211 D02.092.063.291.211 D02.092.877.883.333 D02.675.276.232
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| Concept/Terms |
Choline- Choline
- 2-Hydroxy-N,N,N-trimethylethanaminium
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Below are MeSH descriptors whose meaning is more general than "Choline".
Below are MeSH descriptors whose meaning is more specific than "Choline".
This graph shows the total number of publications written about "Choline" by people in this website by year, and whether "Choline" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 | | 1998 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 1 | 2 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 3 | 1 | 4 | | 2009 | 0 | 4 | 4 | | 2010 | 2 | 0 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 2 | 2 | 4 | | 2013 | 2 | 3 | 5 | | 2014 | 1 | 3 | 4 | | 2015 | 1 | 2 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 2 | 2 | 4 | | 2020 | 1 | 0 | 1 | | 2021 | 3 | 2 | 5 | | 2022 | 1 | 1 | 2 | | 2023 | 1 | 1 | 2 | | 2024 | 3 | 1 | 4 |
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Below are the most recent publications written about "Choline" by people in Profiles.
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Francis EC, Dumolt JH, Zemski-Berry K, Jansson T, Powell TL. Maternal Plasma Choline Levels Are Positively Correlated with Maternal and Placental Phospholipid-DHA Content in Females with Obesity Who Receive DHA Supplementation. J Nutr. 2025 Mar; 155(3):880-889.
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Jia X, Su C, Zhang J, Huang F, Bai J, Guan F, Wei Y, Li L, Liu Y, Ji J, Du W, Ouyang Y, Zhang X, Zhang B, Wang H. Age and Gender Disparities in the Association of Long-Term Dietary Choline and Choline Compound Intakes with Incident Cognitive Decline in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study. Nutrients. 2024 Nov 28; 16(23).
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Bidne KL, Zemski Berry K, Dillon M, Jansson T, Powell TL. Maternal Docosahexaenoic Acid Supplementation Alters Maternal and Fetal Docosahexaenoic Acid Status and Placenta Phospholipids in Pregnancies Complicated by High Body Mass Index. Nutrients. 2024 Sep 02; 16(17).
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Hunter SK, Hoffman MC, D'Alessandro A, Freedman R. Developmental Windows for Effects of Choline and Folate on Excitatory and Inhibitory Neurotransmission During Human Gestation. Dev Psychobiol. 2024 Feb; 66(2).
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Cai LY, Tanase C, Anderson AW, Patel NJ, Lee CA, Jones RS, LeStourgeon LM, Mahon A, Taki I, Juvera J, Pruthi S, Gwal K, Ozturk A, Kang H, Rewers A, Rewers MJ, Alonso GT, Glaser N, Ghetti S, Jaser SS, Landman BA, Jordan LC. Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children. AJNR Am J Neuroradiol. 2023 07; 44(7):820-827.
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James KL, Gertz ER, Kirschke CP, Allayee H, Huang L, Kable ME, Newman JW, Stephensen CB, Bennett BJ. Trimethylamine N-Oxide Response to a Mixed Macronutrient Tolerance Test in a Cohort of Healthy United States Adults. Int J Mol Sci. 2023 Jan 20; 24(3).
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Hoffman MC, Hunter SJ, D'Alessandro A, Christians U, Law AJ, Freedman R. Maternal Plasma Choline during Gestation and Small for Gestational Age Infants. Am J Perinatol. 2024 05; 41(S 01):e939-e948.
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Bhaduri S, Kelly CL, Lesbats C, Sharkey J, Ressel L, Mukherjee S, Platt MD, Delikatny EJ, Poptani H. Metabolic changes in glioblastomas in response to choline kinase inhibition: In vivo MRS in rodent models. NMR Biomed. 2023 03; 36(3):e4855.
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Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness. Schizophr Bull. 2021 07 08; 47(4):896-905.
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Hunter SK, Hoffman MC, D'Alessandro A, Walker VK, Balser M, Noonan K, Law AJ, Freedman R. Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. J Psychiatr Res. 2021 09; 141:50-56.
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