 Choline
"Choline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
| Descriptor ID |
D002794
|
| MeSH Number(s) |
D02.033.100.291.211 D02.092.063.291.211 D02.092.877.883.333 D02.675.276.232
|
| Concept/Terms |
Choline- Choline
- 2-Hydroxy-N,N,N-trimethylethanaminium
|
Below are MeSH descriptors whose meaning is more general than "Choline".
Below are MeSH descriptors whose meaning is more specific than "Choline".
This graph shows the total number of publications written about "Choline" by people in this website by year, and whether "Choline" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 | | 1998 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 1 | 2 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 3 | 0 | 3 | | 2009 | 0 | 4 | 4 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 2 | 3 | | 2012 | 2 | 2 | 4 | | 2013 | 2 | 3 | 5 | | 2014 | 1 | 3 | 4 | | 2015 | 1 | 3 | 4 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 2 | 1 | 3 | | 2020 | 1 | 0 | 1 | | 2021 | 3 | 2 | 5 | | 2022 | 1 | 1 | 2 | | 2023 | 1 | 2 | 3 | | 2024 | 3 | 2 | 5 | | 2025 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Choline" by people in Profiles.
-
Larson EA, Smith LE, Perng W, Switkowski KM, Rifas-Shiman SL, Oken E. The Interplay of Dietary Choline and Methyl Donors in Modulating Maternal Inflammation: Insights from Project Viva. J Nutr. 2025 Jun; 155(6):1999-2005.
-
Borgelt LM, Armstrong M, Brindley S, Brown JM, Reisdorph N, Stamm CA. Content of selected nutrients and heavy metals in prenatal multivitamins and minerals: an observational study. Am J Clin Nutr. 2025 Jun; 121(6):1395-1402.
-
Francis EC, Dumolt JH, Zemski-Berry K, Jansson T, Powell TL. Maternal Plasma Choline Levels Are Positively Correlated with Maternal and Placental Phospholipid-DHA Content in Females with Obesity Who Receive DHA Supplementation. J Nutr. 2025 Mar; 155(3):880-889.
-
Jia X, Su C, Zhang J, Huang F, Bai J, Guan F, Wei Y, Li L, Liu Y, Ji J, Du W, Ouyang Y, Zhang X, Zhang B, Wang H. Age and Gender Disparities in the Association of Long-Term Dietary Choline and Choline Compound Intakes with Incident Cognitive Decline in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study. Nutrients. 2024 Nov 28; 16(23).
-
Calame DG, Wong JH, Panda P, Nguyen DT, Leong NCP, Sangermano R, Patankar SG, Abdel-Hamid MS, AlAbdi L, Safwat S, Flannery KP, Dardas Z, Fatih JM, Murali C, Kannan V, Lotze TE, Herman I, Ammouri F, Rezich B, Efthymiou S, Alavi S, Murphy D, Firoozfar Z, Nasab ME, Bahreini A, Ghasemi M, Haridy NA, Goldouzi HR, Eghbal F, Karimiani EG, Begtrup A, Elloumi H, Srinivasan VM, Gowda VK, Du H, Jhangiani SN, Coban-Akdemir Z, Marafi D, Rodan L, Isikay S, Rosenfeld JA, Ramanathan S, Staton M, Oberg KC, Clark RD, Wenman C, Loughlin S, Saad R, Ashraf T, Male A, Tadros S, Boostani R, Abdel-Salam GMH, Zaki M, Mardi A, Hashemi-Gorji F, Abdalla E, Manzini MC, Pehlivan D, Posey JE, Gibbs RA, Houlden H, Alkuraya FS, Bujakowska K, Maroofian R, Lupski JR, Nguyen LN. Biallelic variation in the choline and ethanolamine transporter FLVCR1 underlies a severe developmental disorder spectrum. Genet Med. 2025 Jan; 27(1):101273.
-
Bidne KL, Zemski Berry K, Dillon M, Jansson T, Powell TL. Maternal Docosahexaenoic Acid Supplementation Alters Maternal and Fetal Docosahexaenoic Acid Status and Placenta Phospholipids in Pregnancies Complicated by High Body Mass Index. Nutrients. 2024 Sep 02; 16(17).
-
Hunter SK, Hoffman MC, D'Alessandro A, Freedman R. Developmental Windows for Effects of Choline and Folate on Excitatory and Inhibitory Neurotransmission During Human Gestation. Dev Psychobiol. 2024 02; 66(2).
-
Massey WJ, Kay KE, Jaramillo TC, Horak AJ, Cao S, Osborn LJ, Banerjee R, Mrdjen M, Hamoudi MK, Silver DJ, Burrows AC, Brown AL, Reizes O, Lathia JD, Wang Z, Hazen SL, Brown JM. Metaorganismal choline metabolism shapes olfactory perception. J Biol Chem. 2023 11; 299(11):105299.
-
Cai LY, Tanase C, Anderson AW, Patel NJ, Lee CA, Jones RS, LeStourgeon LM, Mahon A, Taki I, Juvera J, Pruthi S, Gwal K, Ozturk A, Kang H, Rewers A, Rewers MJ, Alonso GT, Glaser N, Ghetti S, Jaser SS, Landman BA, Jordan LC. Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children. AJNR Am J Neuroradiol. 2023 07; 44(7):820-827.
-
James KL, Gertz ER, Kirschke CP, Allayee H, Huang L, Kable ME, Newman JW, Stephensen CB, Bennett BJ. Trimethylamine N-Oxide Response to a Mixed Macronutrient Tolerance Test in a Cohort of Healthy United States Adults. Int J Mol Sci. 2023 Jan 20; 24(3).
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|