 Hemicholinium 3
"Hemicholinium 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
| Descriptor ID |
D006426
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| MeSH Number(s) |
D02.092.877.435 D02.675.276.435
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hemicholinium 3".
Below are MeSH descriptors whose meaning is more specific than "Hemicholinium 3".
This graph shows the total number of publications written about "Hemicholinium 3" by people in this website by year, and whether "Hemicholinium 3" was a major or minor topic of these publications.
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Below are the most recent publications written about "Hemicholinium 3" by people in Profiles.
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Zheng QH, Gao M, Mock BH, Wang S, Hara T, Nazih R, Miller MA, Receveur TJ, Lopshire JC, Groh WJ, Zipes DP, Hutchins GD, DeGrado TR. Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3. Bioorg Med Chem Lett. 2007 Apr 15; 17(8):2220-4.
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Gao M, Miller MA, DeGrado TR, Mock BH, Lopshire JC, Rosenberger JG, Dusa C, Das MK, Groh WJ, Zipes DP, Hutchins GD, Zheng QH. Evaluation of [11C]hemicholinium-15 and [18F]hemicholinium-15 as new potential PET tracers for the high-affinity choline uptake system in the heart. Bioorg Med Chem. 2007 Feb 01; 15(3):1289-97.
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Hara T, Bansal A, DeGrado TR. Choline transporter as a novel target for molecular imaging of cancer. Mol Imaging. 2006 Oct-Dec; 5(4):498-509.
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Chao CK, Pomfret EA, Zeisel SH. Uptake of choline by rat mammary-gland epithelial cells. Biochem J. 1988 Aug 15; 254(1):33-8.
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Altiere RJ, Szarek JL, Diamond L. Neurally mediated nonadrenergic relaxation in cat airways occurs independent of cholinergic mechanisms. J Pharmacol Exp Ther. 1985 Sep; 234(3):590-7.
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