 Founder Effect
"Founder Effect" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
| Descriptor ID |
D018703
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| MeSH Number(s) |
G05.285
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| Concept/Terms |
Founder Effect- Founder Effect
- Effect, Founder
- Effects, Founder
- Founder Effects
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Below are MeSH descriptors whose meaning is more general than "Founder Effect".
Below are MeSH descriptors whose meaning is more specific than "Founder Effect".
This graph shows the total number of publications written about "Founder Effect" by people in this website by year, and whether "Founder Effect" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 | | 2018 | 0 | 2 | 2 |
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Below are the most recent publications written about "Founder Effect" by people in Profiles.
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Smith CCR, Flaxman SM, Scordato ESC, Kane NC, Hund AK, Sheta BM, Safran RJ. Demographic inference in barn swallows using whole-genome data shows signal for bottleneck and subspecies differentiation during the Holocene. Mol Ecol. 2018 11; 27(21):4200-4212.
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Udler MS, Kim J, von Grotthuss M, Bon?s-Guarch S, Cole JB, Chiou J, Boehnke M, Laakso M, Atzmon G, Glaser B, Mercader JM, Gaulton K, Flannick J, Getz G, Florez JC. Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis. PLoS Med. 2018 09; 15(9):e1002654.
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Fantauzzo KA, Soriano P. Generation of an immortalized mouse embryonic palatal mesenchyme cell line. PLoS One. 2017; 12(6):e0179078.
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Szucs M, Melbourne BA, Tuff T, Weiss-Lehman C, Hufbauer RA. Genetic and demographic founder effects have long-term fitness consequences for colonising populations. Ecol Lett. 2017 04; 20(4):436-444.
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Percival CJ, Liberton DK, Pardo-Manuel de Villena F, Spritz R, Marcucio R, Hallgr?msson B. Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross. J Anat. 2016 Jan; 228(1):96-112.
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Simbiri KO, Smith NA, Otieno R, Wohlford EE, Daud II, Odada SP, Middleton F, Rochford R. Epstein-Barr virus genetic variation in lymphoblastoid cell lines derived from Kenyan pediatric population. PLoS One. 2015; 10(5):e0125420.
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Fu C, Ess KC. Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells. Genesis. 2013 Apr; 51(4):284-92.
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Akkina R. New generation humanized mice for virus research: comparative aspects and future prospects. Virology. 2013 Jan 05; 435(1):14-28.
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Birlea SA, Gowan K, Fain PR, Spritz RA. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. J Invest Dermatol. 2010 Mar; 130(3):798-803.
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Sharthkumar A, Greist A, Di Paola J, Winay J, Roberson C, Heiman M, Herbert S, Parameswaran R, Shapiro A. Biologic response to subcutaneous and intranasal therapy with desmopressin in a large Amish kindred with Type 2M von Willebrand disease. Haemophilia. 2008 May; 14(3):539-48.
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