 Immunoglobulin Variable Region
"Immunoglobulin Variable Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
| Descriptor ID |
D007135
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| MeSH Number(s) |
D12.644.541.500.650.500 D12.776.124.486.485.680.650.500 D12.776.124.486.485.797 D12.776.124.790.651.680.650.500 D12.776.124.790.651.797 D12.776.377.715.548.680.650.500 D12.776.377.715.548.797 G02.111.570.060.425
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| Concept/Terms |
Immunoglobulin Variable Region- Immunoglobulin Variable Region
- Immunoglobulin Variable Regions
- Regions, Immunoglobulin Variable
- Variable Regions, Immunoglobulin
- Ig Variable Region
- Variable Region, Ig
- Ig Variable Regions
- Variable Regions, Ig
- Variable Region, Immunoglobulin
- Immunoglobulin V
Immunoglobulin Fv Fragments- Immunoglobulin Fv Fragments
- Fragment, Immunoglobulin Fv
- Fragments, Immunoglobulin Fv
- Fv Fragment, Immunoglobulin
- Fv Fragments, Immunoglobulin
- Immunoglobulin Fv Fragment
- Fv Antibody Fragments
- Antibody Fragment, Fv
- Antibody Fragments, Fv
- Fragment, Fv Antibody
- Fragments, Fv Antibody
- Fv Antibody Fragment
- Fv Fragments
- Fragment, Fv
- Fragments, Fv
- Fv Fragment
Framework Region, Immunoglobulin- Framework Region, Immunoglobulin
- Framework Regions, Immunoglobulin
- Immunoglobulin Framework Regions
- Ig Framework Region
- Framework Region, Ig
- Framework Regions, Ig
- Ig Framework Regions
- Immunoglobulin Framework Region
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Variable Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Variable Region".
This graph shows the total number of publications written about "Immunoglobulin Variable Region" by people in this website by year, and whether "Immunoglobulin Variable Region" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 1 | 3 | | 1997 | 1 | 1 | 2 | | 1998 | 1 | 2 | 3 | | 1999 | 2 | 1 | 3 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 2 | 3 | | 2002 | 1 | 3 | 4 | | 2003 | 1 | 2 | 3 | | 2004 | 3 | 1 | 4 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Variable Region" by people in Profiles.
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Petersen BM, Ulmer SA, Rhodes ER, Gutierrez-Gonzalez MF, Dekosky BJ, Sprenger KG, Whitehead TA. Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires. Front Immunol. 2021; 12:728694.
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Guo K, Halemano K, Schmitt K, Katuwal M, Wang Y, Harper MS, Heilman KJ, Kuwata T, Stephens EB, Santiago ML. Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques. Immunogenetics. 2015 Jul; 67(7):355-70.
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Novinger LJ, Ashikaga T, Krag DN. Identification of tumor-binding scFv derived from clonally related B cells in tumor and lymph node of a patient with breast cancer. Cancer Immunol Immunother. 2015 Jan; 64(1):29-39.
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Bowers E, Scamurra RW, Asrani A, Beniguel L, MaWhinney S, Keays KM, Thurn JR, Janoff EN. Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection. PLoS One. 2014; 9(1):e81913.
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Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ, Meltzer PS. High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet. 2014 Jan; 46(1):8-10.
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Gopalakrishnan S, Majumder K, Predeus A, Huang Y, Koues OI, Verma-Gaur J, Loguercio S, Su AI, Feeney AJ, Artyomov MN, Oltz EM. Unifying model for molecular determinants of the preselection V? repertoire. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):E3206-15.
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Bedel R, Matsuda JL, Brigl M, White J, Kappler J, Marrack P, Gapin L. Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol. 2012 Jul 19; 13(8):705-6.
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Arruda DC, Santos LC, Melo FM, Pereira FV, Figueiredo CR, Matsuo AL, Mortara RA, Juliano MA, Rodrigues EG, Dobroff AS, Polonelli L, Travassos LR. ?-Actin-binding complementarity-determining region 2 of variable heavy chain from monoclonal antibody C7 induces apoptosis in several human tumor cells and is protective against metastatic melanoma. J Biol Chem. 2012 Apr 27; 287(18):14912-22.
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Detanico T, Heiser RA, Aviszus K, Bonorino C, Wysocki LJ. Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor. J Immunol. 2011 Jul 01; 187(1):82-91.
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Heiser RA, Snyder CM, St Clair J, Wysocki LJ. Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide. J Immunol. 2011 Jul 01; 187(1):212-21.
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