 Mutagenesis, Site-Directed
"Mutagenesis, Site-Directed" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
| Descriptor ID |
D016297
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| MeSH Number(s) |
E05.393.420.601.575
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| Concept/Terms |
Mutagenesis, Site-Directed- Mutagenesis, Site-Directed
- Mutagenesis, Site Directed
- Site-Specific Mutagenesis
- Site Specific Mutagenesis
- Mutagenesis, Site-Specific
- Mutageneses, Site-Specific
- Mutagenesis, Site Specific
- Site-Specific Mutageneses
- Site-Directed Mutagenesis
- Mutageneses, Site-Directed
- Site Directed Mutagenesis
- Site-Directed Mutageneses
Oligonucleotide-Directed Mutagenesis- Oligonucleotide-Directed Mutagenesis
- Oligonucleotide Directed Mutagenesis
- Mutagenesis, Oligonucleotide-Directed
- Mutageneses, Oligonucleotide-Directed
- Mutagenesis, Oligonucleotide Directed
- Oligonucleotide-Directed Mutageneses
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Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Site-Directed".
Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Site-Directed".
This graph shows the total number of publications written about "Mutagenesis, Site-Directed" by people in this website by year, and whether "Mutagenesis, Site-Directed" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 2 | 6 | 8 | | 1992 | 2 | 10 | 12 | | 1993 | 1 | 13 | 14 | | 1994 | 1 | 4 | 5 | | 1995 | 1 | 8 | 9 | | 1996 | 0 | 17 | 17 | | 1997 | 0 | 18 | 18 | | 1998 | 2 | 15 | 17 | | 1999 | 0 | 8 | 8 | | 2000 | 1 | 12 | 13 | | 2001 | 2 | 13 | 15 | | 2002 | 1 | 16 | 17 | | 2003 | 4 | 18 | 22 | | 2004 | 1 | 18 | 19 | | 2005 | 1 | 12 | 13 | | 2006 | 0 | 16 | 16 | | 2007 | 1 | 12 | 13 | | 2008 | 0 | 16 | 16 | | 2009 | 0 | 10 | 10 | | 2010 | 0 | 16 | 16 | | 2011 | 0 | 10 | 10 | | 2012 | 0 | 15 | 15 | | 2013 | 0 | 8 | 8 | | 2014 | 0 | 5 | 5 | | 2015 | 0 | 4 | 4 | | 2016 | 1 | 10 | 11 | | 2017 | 0 | 6 | 6 | | 2018 | 0 | 5 | 5 | | 2019 | 1 | 2 | 3 | | 2020 | 1 | 2 | 3 |
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Below are the most recent publications written about "Mutagenesis, Site-Directed" by people in Profiles.
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Mukherjee S, Hung ST, Douglas N, Manna P, Thomas C, Ekrem A, Palmer AE, Jimenez R. Engineering of a Brighter Variant of the FusionRed Fluorescent Protein Using Lifetime Flow Cytometry and Structure-Guided Mutations. Biochemistry. 2020 10 06; 59(39):3669-3682.
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Shirts MR, Ferguson AL. Statistically Optimal Continuous Free Energy Surfaces from Biased Simulations and Multistate Reweighting. J Chem Theory Comput. 2020 Jul 14; 16(7):4107-4125.
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Bharadwaj VS, Knott BC, Ståhlberg J, Beckham GT, Crowley MF. The hydrolysis mechanism of a GH45 cellulase and its potential relation to lytic transglycosylase and expansin function. J Biol Chem. 2020 04 03; 295(14):4477-4487.
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Bandi S, Singh SM, Shah DD, Upadhyay V, Mallela KMG. 2D NMR Analysis of the Effect of Asparagine Deamidation Versus Methionine Oxidation on the Structure, Stability, Aggregation, and Function of a Therapeutic Protein. Mol Pharm. 2019 11 04; 16(11):4621-4635.
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Medina-Cucurella AV, Steiner PJ, Faber MS, Beltrán J, Borelli AN, Kirby MB, Cutler SR, Whitehead TA. User-defined single pot mutagenesis using unamplified oligo pools. Protein Eng Des Sel. 2019 09 10; 32(1):41-45.
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Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, Ge K, Kutateladze TG. Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF. Nat Commun. 2019 05 24; 10(1):2314.
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Zambrano CA, Escobar D, Ramos-Santiago T, Bollinger I, Stitzel J. Serine residues in the a4 nicotinic acetylcholine receptor subunit regulate surface a4ß2* receptor expression and clustering. Biochem Pharmacol. 2019 01; 159:64-73.
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Vasquez JJ, Wedel C, Cosentino RO, Siegel TN. Exploiting CRISPR-Cas9 technology to investigate individual histone modifications. Nucleic Acids Res. 2018 10 12; 46(18):e106.
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Glustrom LW, Lyon KR, Paschini M, Reyes CM, Parsonnet NV, Toro TB, Lundblad V, Wuttke DS. Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10315-10320.
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Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 07 12; 174(2):300-311.e11.
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