 Diacylglycerol O-Acyltransferase
"Diacylglycerol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyses the last step of the TRIACYLGLYCEROL synthesis reaction in which diacylglycerol is covalently joined to LONG-CHAIN ACYL COA to form triglyceride. It was formerly categorized as EC 2.3.1.124.
| Descriptor ID |
D051048
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| MeSH Number(s) |
D08.811.913.050.387
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| Concept/Terms |
Diacylglycerol O-Acyltransferase- Diacylglycerol O-Acyltransferase
- Diacylglycerol O Acyltransferase
- O-Acyltransferase, Diacylglycerol
- DAGAT Enzyme
- Palmitoyl-Coenzyme A-sn-1,2-Diacylglycerol Acyltransferase
- A-sn-1,2-Diacylglycerol Acyltransferase, Palmitoyl-Coenzyme
- Acyltransferase, Palmitoyl-Coenzyme A-sn-1,2-Diacylglycerol
- Palmitoyl Coenzyme A sn 1,2 Diacylglycerol Acyltransferase
- Diacylglycerol O-Acyltransferase 1
- Diacylglycerol O Acyltransferase 1
- O-Acyltransferase 1, Diacylglycerol
- Diglyceride Acyltransferase
- Acyltransferase, Diglyceride
- Palmitoyl-CoA-sn-1,2-Diacylglycerol Acyltransferase
- Acyltransferase, Palmitoyl-CoA-sn-1,2-Diacylglycerol
- Palmitoyl CoA sn 1,2 Diacylglycerol Acyltransferase
- Acyl-Coenzyme A Diacyl-glycerol Acyltransferase
- Acyl Coenzyme A Diacyl glycerol Acyltransferase
- Diacylglycerol Acyltransferase
- Acyltransferase, Diacylglycerol
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Below are MeSH descriptors whose meaning is more general than "Diacylglycerol O-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Diacylglycerol O-Acyltransferase".
This graph shows the total number of publications written about "Diacylglycerol O-Acyltransferase" by people in this website by year, and whether "Diacylglycerol O-Acyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 2 | 0 | 2 | | 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Diacylglycerol O-Acyltransferase" by people in Profiles.
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Heden TD, Morris EM, Kearney ML, Liu TW, Park YM, Kanaley JA, Thyfault JP. Differential effects of low-fat and high-fat diets on fed-state hepatic triacylglycerol secretion, hepatic fatty acid profiles, and DGAT-1 protein expression in obese-prone Sprague-Dawley rats. Appl Physiol Nutr Metab. 2014 Apr; 39(4):472-9.
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Jackson KC, Wohlers LM, Valencia AP, Cilenti M, Borengasser SJ, Thyfault JP, Spangenburg EE. Wheel running prevents the accumulation of monounsaturated fatty acids in the liver of ovariectomized mice by attenuating changes in SCD-1 content. Appl Physiol Nutr Metab. 2011 Dec; 36(6):798-810.
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Ranganathan G, Unal R, Pokrovskaya I, Yao-Borengasser A, Phanavanh B, Lecka-Czernik B, Rasouli N, Kern PA. The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. J Lipid Res. 2006 Nov; 47(11):2444-50.
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Man WC, Miyazaki M, Chu K, Ntambi J. Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. J Lipid Res. 2006 Sep; 47(9):1928-39.
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Dobrzyn A, Dobrzyn P, Miyazaki M, Sampath H, Chu K, Ntambi JM. Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J Biol Chem. 2005 Jun 17; 280(24):23356-62.
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Quittnat F, Nishikawa Y, Stedman TT, Voelker DR, Choi JY, Zahn MM, Murphy RC, Barkley RM, Pypaert M, Joiner KA, Coppens I. On the biogenesis of lipid bodies in ancient eukaryotes: synthesis of triacylglycerols by a Toxoplasma DGAT1-related enzyme. Mol Biochem Parasitol. 2004 Nov; 138(1):107-22.
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Chen HC, Jensen DR, Myers HM, Eckel RH, Farese RV. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2003 Jun; 111(11):1715-22.
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Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2002 Apr; 109(8):1049-55.
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Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000 May; 25(1):87-90.
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