 Diacylglycerol O-Acyltransferase
"Diacylglycerol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyses the last step of the TRIACYLGLYCEROL synthesis reaction in which diacylglycerol is covalently joined to LONG-CHAIN ACYL COA to form triglyceride. It was formerly categorized as EC 2.3.1.124.
| Descriptor ID |
D051048
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| MeSH Number(s) |
D08.811.913.050.387
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| Concept/Terms |
Diacylglycerol O-Acyltransferase- Diacylglycerol O-Acyltransferase
- Diacylglycerol O Acyltransferase
- O-Acyltransferase, Diacylglycerol
- DAGAT Enzyme
- Palmitoyl-Coenzyme A-sn-1,2-Diacylglycerol Acyltransferase
- A-sn-1,2-Diacylglycerol Acyltransferase, Palmitoyl-Coenzyme
- Acyltransferase, Palmitoyl-Coenzyme A-sn-1,2-Diacylglycerol
- Palmitoyl Coenzyme A sn 1,2 Diacylglycerol Acyltransferase
- Diacylglycerol O-Acyltransferase 1
- Diacylglycerol O Acyltransferase 1
- O-Acyltransferase 1, Diacylglycerol
- Diglyceride Acyltransferase
- Acyltransferase, Diglyceride
- Palmitoyl-CoA-sn-1,2-Diacylglycerol Acyltransferase
- Acyltransferase, Palmitoyl-CoA-sn-1,2-Diacylglycerol
- Palmitoyl CoA sn 1,2 Diacylglycerol Acyltransferase
- Acyl-Coenzyme A Diacyl-glycerol Acyltransferase
- Acyl Coenzyme A Diacyl glycerol Acyltransferase
- Diacylglycerol Acyltransferase
- Acyltransferase, Diacylglycerol
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Below are MeSH descriptors whose meaning is more general than "Diacylglycerol O-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Diacylglycerol O-Acyltransferase".
This graph shows the total number of publications written about "Diacylglycerol O-Acyltransferase" by people in this website by year, and whether "Diacylglycerol O-Acyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2006 | 2 | 0 | 2 |
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Below are the most recent publications written about "Diacylglycerol O-Acyltransferase" by people in Profiles.
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Heden TD, Morris EM, Kearney ML, Liu TW, Park YM, Kanaley JA, Thyfault JP. Differential effects of low-fat and high-fat diets on fed-state hepatic triacylglycerol secretion, hepatic fatty acid profiles, and DGAT-1 protein expression in obese-prone Sprague-Dawley rats. Appl Physiol Nutr Metab. 2014 Apr; 39(4):472-9.
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Barlind JG, Bauer UA, Birch AM, Birtles S, Buckett LK, Butlin RJ, Davies RD, Eriksson JW, Hammond CD, Hovland R, Johannesson P, Johansson MJ, Kemmitt PD, Lindmark BT, Morentin Gutierrez P, Noeske TA, Nordin A, O'Donnell CJ, Petersson AU, Redzic A, Turnbull AV, Vinblad J. Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem. 2012 Dec 13; 55(23):10610-29.
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McCoull W, Addie MS, Birch AM, Birtles S, Buckett LK, Butlin RJ, Bowker SS, Boyd S, Chapman S, Davies RD, Donald CS, Green CP, Jenner C, Kemmitt PD, Leach AG, Moody GC, Gutierrez PM, Newcombe NJ, Nowak T, Packer MJ, Plowright AT, Revill J, Schofield P, Sheldon C, Stokes S, Turnbull AV, Wang SJ, Whalley DP, Wood JM. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012 Jun 15; 22(12):3873-8.
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Jackson KC, Wohlers LM, Valencia AP, Cilenti M, Borengasser SJ, Thyfault JP, Spangenburg EE. Wheel running prevents the accumulation of monounsaturated fatty acids in the liver of ovariectomized mice by attenuating changes in SCD-1 content. Appl Physiol Nutr Metab. 2011 Dec; 36(6):798-810.
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Ranganathan G, Unal R, Pokrovskaya I, Yao-Borengasser A, Phanavanh B, Lecka-Czernik B, Rasouli N, Kern PA. The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. J Lipid Res. 2006 Nov; 47(11):2444-50.
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Man WC, Miyazaki M, Chu K, Ntambi J. Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. J Lipid Res. 2006 Sep; 47(9):1928-39.
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Dobrzyn A, Dobrzyn P, Miyazaki M, Sampath H, Chu K, Ntambi JM. Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J Biol Chem. 2005 Jun 17; 280(24):23356-62.
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Quittnat F, Nishikawa Y, Stedman TT, Voelker DR, Choi JY, Zahn MM, Murphy RC, Barkley RM, Pypaert M, Joiner KA, Coppens I. On the biogenesis of lipid bodies in ancient eukaryotes: synthesis of triacylglycerols by a Toxoplasma DGAT1-related enzyme. Mol Biochem Parasitol. 2004 Nov; 138(1):107-22.
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Chen HC, Jensen DR, Myers HM, Eckel RH, Farese RV. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2003 Jun; 111(11):1715-22.
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Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000 May; 25(1):87-90.
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