Item Type | Name |
Concept
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Jurkat Cells
|
Concept
|
Lymphoma, T-Cell
|
Concept
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Cell Movement
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Concept
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Hematopoietic Stem Cells
|
Concept
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Cell Death
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Concept
|
Receptors, Antigen, T-Cell, alpha-beta
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Concept
|
Cell Lineage
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Concept
|
Receptors, Antigen, T-Cell
|
Concept
|
T-Cell Antigen Receptor Specificity
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Concept
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HeLa Cells
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Concept
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Cell Division
|
Concept
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Cell Survival
|
Concept
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Cell Cycle
|
Concept
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Cord Blood Stem Cell Transplantation
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Concept
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Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
|
Concept
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Stem Cell Factor
|
Concept
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Clone Cells
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Concept
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Cell Migration Inhibition
|
Concept
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K562 Cells
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Concept
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Th1 Cells
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Concept
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NIH 3T3 Cells
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Concept
|
Receptor-CD3 Complex, Antigen, T-Cell
|
Concept
|
Dendritic Cells
|
Concept
|
Resting Phase, Cell Cycle
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Concept
|
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
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Concept
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Genes, T-Cell Receptor
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Concept
|
Cell Aggregation
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Concept
|
CHO Cells
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Concept
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Stromal Cells
|
Concept
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Th2 Cells
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Concept
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Cell Line
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Concept
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Tumor Cells, Cultured
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Concept
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Cell Differentiation
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Concept
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Cell Line, Transformed
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Concept
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Bone Marrow Cells
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Concept
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Mast Cells
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Concept
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NK Cell Lectin-Like Receptor Subfamily C
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Concept
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Receptors, Antigen, B-Cell
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Concept
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Killer Cells, Natural
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Concept
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Cell Line, Tumor
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Concept
|
Cell Polarity
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Concept
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Cells, Cultured
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Concept
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Stem Cells
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Concept
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Cell Separation
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Concept
|
Receptors, Antigen, T-Cell, gamma-delta
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Concept
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Natural Killer T-Cells
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Concept
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Cell Proliferation
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Academic Article
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Alterations in CD4 dependence accompany T cell development and differentiation.
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Academic Article
|
Innate PLZF+CD4+ a? T cells develop and expand in the absence of Itk.
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Academic Article
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Induction of cytotoxic T-cell response by optimal-length peptides does not require CD4+ T-cell help.
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Academic Article
|
Regulatory intramolecular association in a tyrosine kinase of the Tec family.
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Academic Article
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A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.
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Academic Article
|
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.
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Academic Article
|
Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection.
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Academic Article
|
The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.
|
Academic Article
|
Generation of the T cell repertoire.
|
Academic Article
|
Structurally similar TCRs differ in their efficiency of positive selection.
|
Academic Article
|
T-cell development in T cell receptor alphabeta transgenic mice.
|
Academic Article
|
Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain.
|
Academic Article
|
The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.
|
Academic Article
|
Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice.
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Academic Article
|
Itk and Th2 responses: action but no reaction.
|
Academic Article
|
Do the CD4 and CD8 lineages represent parallel pathways?
|
Academic Article
|
Molecular determinants of TCR expression and selection.
|
Academic Article
|
T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis.
|
Academic Article
|
A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.
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Academic Article
|
Itk is not essential for CD28 signaling in naive T cells.
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Academic Article
|
The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
|
Academic Article
|
IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection.
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Academic Article
|
Expression of T-cell receptor alpha-chain genes in transgenic mice.
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Academic Article
|
A network of high-mobility group box transcription factors programs innate interleukin-17 production.
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Academic Article
|
T cell development and activation in Jak3-deficient mice.
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Academic Article
|
Compartmentalized Eph receptor and ephrin expression in the thymus.
|
Academic Article
|
Peptide Antigen Concentration Modulates Digital NFAT1 Activation in Primary Mouse Naive CD8+ T Cells as Measured by Flow Cytometry of Isolated Cell Nuclei.
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Academic Article
|
The Transcription Factor Runx2 Is Required for Long-Term Persistence of Antiviral CD8+ Memory T Cells.
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Academic Article
|
Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.
|
Academic Article
|
Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation.
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Academic Article
|
Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals.
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Academic Article
|
In vivo priming of cytotoxic T lymphocyte responses in relation to in vitro up-regulation of major histocompatibility complex class I molecules by short synthetic peptides.
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Academic Article
|
Tec kinases in T cell and mast cell signaling.
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Academic Article
|
Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase.
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Academic Article
|
T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells.
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Academic Article
|
Strength of T cell receptor signaling strikes again.
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Academic Article
|
Signals that regulate lymphocyte development and differentiation.
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Academic Article
|
Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development.
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Academic Article
|
Regulation of tissue-dependent differences in CD8+ T cell apoptosis during viral infection.
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Academic Article
|
Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.
|
Academic Article
|
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3.
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Academic Article
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The effects of MHC gene dosage and allelic variation on T cell receptor selection.
|
Academic Article
|
Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection.
|
Academic Article
|
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.
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Academic Article
|
Quantitative analysis of the efficiency of clonal deletion in the thymus.
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Academic Article
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c-Abl, an additional tyrosine kinase required for T cell development and function.
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Academic Article
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Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.
|
Academic Article
|
Genomic structure and promoter region of the murine Janus-family tyrosine kinase, Jak3.
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Academic Article
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A profound deficiency in thymic progenitor cells in mice lacking Jak3.
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Academic Article
|
Jarid2 is induced by TCR signalling and controls iNKT cell maturation.
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Academic Article
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CD28 and ITK signals regulate autoreactive T cell trafficking.
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Academic Article
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The Tec kinase ITK regulates thymic expansion, emigration, and maturation of ?d NKT cells.
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Academic Article
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T-cell signaling regulated by the Tec family kinase, Itk.
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Academic Article
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Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.
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Academic Article
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Tec family kinases in T lymphocyte development and function.
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Academic Article
|
Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo.
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Academic Article
|
Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.
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Academic Article
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Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development.
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Academic Article
|
Type 1 interferon licenses na?ve CD8 T cells to mediate anti-viral cytotoxicity.
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Academic Article
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Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.
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Academic Article
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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
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Academic Article
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High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells.
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Academic Article
|
Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection.
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Academic Article
|
Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells.
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Academic Article
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Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.
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Academic Article
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Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.
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Academic Article
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TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
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Academic Article
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Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling.
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Academic Article
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Identification of Itk/Tsk Src homology 3 domain ligands.
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Academic Article
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Down-regulation of the T cell receptor CD3 zeta chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness.
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Academic Article
|
Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet.
|
Academic Article
|
Signaling pathways that regulate T cell development and differentiation.
|
Academic Article
|
Disrupting the intermolecular self-association of Itk enhances T cell signaling.
|
Academic Article
|
Enhanced T cell maturation and altered lineage commitment in T cell receptor/CD4-transgenic mice.
|
Academic Article
|
Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk.
|
Academic Article
|
The role of Tec family kinases in T cell development and function.
|
Academic Article
|
Intrathymic programming of effector fates in three molecularly distinct ?d T cell subtypes.
|
Academic Article
|
Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression.
|
Academic Article
|
Itk phosphorylation sites are required for functional activity in primary T cells.
|
Academic Article
|
IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.
|
Academic Article
|
Gene-enhancer variants reveal diverse TCR-mediated differentiation.
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Academic Article
|
Herpes simplex virus infection downmodulates NKG2D ligand expression.
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Academic Article
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T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells.
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Academic Article
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Characterization of long-term mixed donor-donor chimerism after double cord blood transplantation.
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Academic Article
|
The signal transduction of motion and antigen recognition: factors affecting T cell function and differentiation.
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Academic Article
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Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.
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Academic Article
|
Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.
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Academic Article
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The role of cytokine receptor signaling in lymphocyte development.
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Academic Article
|
Suppression of systemic autoimmunity by the innate immune adaptor STING.
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Academic Article
|
Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.
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Academic Article
|
Chromophore-assisted laser inactivation of subunits of the T-cell receptor in living cells is spatially restricted.
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Academic Article
|
The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells.
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Academic Article
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The "bubble boy" paradox: an answer that led to a question.
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Academic Article
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NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
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Academic Article
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A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis.
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Academic Article
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Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization.
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Academic Article
|
Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals.
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Academic Article
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Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
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Grant
|
Immunobiology of Jak3 Deficient Mice
|
Grant
|
THYMIC SELECTION AND T CELL LINEAGE COMMITMENT
|
Grant
|
Regulation of anti-viral T cell responses by IRF4
|
Grant
|
Response to viral infection in immunodeficient mice
|
Grant
|
Tec family tyrosine kinases in T cell signaling
|
Grant
|
Tec Kinases ltk and RlK in Mast Cell Signaling
|
Grant
|
Regulation of conventional versus innate CD8+ T cell development
|
Grant
|
Plasticity of T helper cell differentiation
|
Grant
|
Screening for inhibitors of the T cell Tec kinase, ltk
|
Grant
|
FASEB SRC on Signal Transduction in the Immune System
|
Grant
|
FASEB Summer Research Conference: Lymphocytes/Antibodies
|
Grant
|
ITK: an emerging target for treatment of T cell-mediated autoimmune disease
|
Academic Article
|
The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine.
|
Concept
|
Th17 Cells
|
Concept
|
Sf9 Cells
|
Academic Article
|
TCR signaling: it's all about the numbers.
|
Academic Article
|
CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.
|
Academic Article
|
Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength.
|
Academic Article
|
Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK.
|
Academic Article
|
Interplay between IL-10, IFN-?, IL-17A and PD-1 Expressing EBNA1-Specific CD4+ and CD8+ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma.
|
Academic Article
|
Analysis of T-cell Receptor-Induced Calcium Influx in Primary Murine T-cells by Full Spectrum Flow Cytometry.
|
Grant
|
Structural Studies of a T cell Specific Tyrosine Kinase
|