Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.
Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ. Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J Biol Chem. 1997 Oct 03; 272(40):25401-8.