 alpha7 Nicotinic Acetylcholine Receptor
"alpha7 Nicotinic Acetylcholine Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric α7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.
| Descriptor ID |
D064569
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| MeSH Number(s) |
D12.776.157.530.400.400.100.500.500 D12.776.543.550.450.500.100.500.500 D12.776.543.585.400.500.100.500.500 D12.776.543.750.130.687.500 D12.776.543.750.720.360.550.500
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| Concept/Terms |
Receptor, alpha-Bungarotoxin- Receptor, alpha-Bungarotoxin
- Receptor, alpha Bungarotoxin
- alpha-Bungarotoxin Receptor
- alpha-Bungarotoxin Receptors
- Receptors, alpha-Bungarotoxin
- alpha Bungarotoxin Receptors
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Below are MeSH descriptors whose meaning is more general than "alpha7 Nicotinic Acetylcholine Receptor".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Ligand-Gated Ion Channels [D12.776.157.530.400.400]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
- Receptors, Nicotinic [D12.776.157.530.400.400.100.500]
- alpha7 Nicotinic Acetylcholine Receptor [D12.776.157.530.400.400.100.500.500]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.450]
- Ligand-Gated Ion Channels [D12.776.543.550.450.500]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.450.500.100]
- Receptors, Nicotinic [D12.776.543.550.450.500.100.500]
- alpha7 Nicotinic Acetylcholine Receptor [D12.776.543.550.450.500.100.500.500]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Ligand-Gated Ion Channels [D12.776.543.585.400.500]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
- Receptors, Nicotinic [D12.776.543.585.400.500.100.500]
- alpha7 Nicotinic Acetylcholine Receptor [D12.776.543.585.400.500.100.500.500]
- Receptors, Cell Surface [D12.776.543.750]
- Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.750.130]
- Receptors, Nicotinic [D12.776.543.750.130.687]
- alpha7 Nicotinic Acetylcholine Receptor [D12.776.543.750.130.687.500]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Cholinergic [D12.776.543.750.720.360]
- Receptors, Nicotinic [D12.776.543.750.720.360.550]
- alpha7 Nicotinic Acetylcholine Receptor [D12.776.543.750.720.360.550.500]
Below are MeSH descriptors whose meaning is more specific than "alpha7 Nicotinic Acetylcholine Receptor".
This graph shows the total number of publications written about "alpha7 Nicotinic Acetylcholine Receptor" by people in this website by year, and whether "alpha7 Nicotinic Acetylcholine Receptor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 3 | 3 | | 2008 | 0 | 3 | 3 | | 2009 | 0 | 6 | 6 | | 2010 | 0 | 4 | 4 | | 2011 | 0 | 3 | 3 | | 2012 | 0 | 4 | 4 | | 2013 | 1 | 2 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 4 | 0 | 4 | | 2016 | 4 | 1 | 5 | | 2017 | 2 | 1 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 2 | 0 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "alpha7 Nicotinic Acetylcholine Receptor" by people in Profiles.
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Navarro E, Norden DM, Trojanowski PJ, Godbout JP, L?pez MG. Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals. Molecules. 2021 Apr 07; 26(8).
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Minguez-Vi?as T, Nielsen BE, Shoemark DK, Gotti C, Sessions RB, Mulholland AJ, Bouzat C, Wonnacott S, Gallagher T, Bermudez I, Oliveira AS. A conserved arginine with non-conserved function is a key determinant of agonist selectivity in a7 nicotinic ACh receptors. Br J Pharmacol. 2021 04; 178(7):1651-1668.
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Nielsen BE, Stabile S, Vitale C, Bouzat C. Design, Synthesis, and Functional Evaluation of a Novel Series of Phosphonate-Functionalized 1,2,3-Triazoles as Positive Allosteric Modulators of a7 Nicotinic Acetylcholine Receptors. ACS Chem Neurosci. 2020 09 02; 11(17):2688-2704.
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Nielsen BE, Bermudez I, Bouzat C. Flavonoids as positive allosteric modulators of a7 nicotinic receptors. Neuropharmacology. 2019 12 01; 160:107794.
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Tregellas JR, Wylie KP. Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia. Nicotine Tob Res. 2019 02 18; 21(3):349-356.
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Nielsen BE, Minguez T, Bermudez I, Bouzat C. Molecular function of the novel a7?2 nicotinic receptor. Cell Mol Life Sci. 2018 Jul; 75(13):2457-2471.
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Bouzat C, Lasala M, Nielsen BE, Corradi J, Esandi MDC. Molecular function of a7 nicotinic receptors as drug targets. J Physiol. 2018 05 15; 596(10):1847-1861.
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Kem WR, Olincy A, Johnson L, Harris J, Wagner BD, Buchanan RW, Christians U, Freedman R. Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation. Neuropsychopharmacology. 2018 02; 43(3):583-589.
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Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O'Connell K, Jeong EM, Dudley SC, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G. Effect of a7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol. 2017 05 01; 312(5):L748-L759.
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Gee KW, Olincy A, Kanner R, Johnson L, Hogenkamp D, Harris J, Tran M, Edmonds SA, Sauer W, Yoshimura R, Johnstone T, Freedman R. First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. J Psychopharmacol. 2017 04; 31(4):434-441.
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