 N-Formylmethionine Leucyl-Phenylalanine
"N-Formylmethionine Leucyl-Phenylalanine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.
| Descriptor ID |
D009240
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| MeSH Number(s) |
D02.886.030.676.450.440 D12.125.072.050.685.445 D12.125.142.666.500 D12.125.166.676.450.440 D12.644.456.400 D23.125.685
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| Concept/Terms |
N-Formylmethionine Leucyl-Phenylalanine- N-Formylmethionine Leucyl-Phenylalanine
- Leucyl-Phenylalanine, N-Formylmethionine
- N Formylmethionine Leucyl Phenylalanine
- Formylmethionyl-Leucyl-Phenylalanine
- Formylmethionyl Leucyl Phenylalanine
- N-Formyl-Methionyl-Leucyl-Phenylalanine
- N Formyl Methionyl Leucyl Phenylalanine
- Formylmet-Leu-Phe
- Formylmet Leu Phe
- Formylmethionylleucylphenylalanine
Formylmethionyl Peptide- Formylmethionyl Peptide
- Peptide, Formylmethionyl
- N-Formylated Peptide
- N Formylated Peptide
- Peptide, N-Formylated
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Below are MeSH descriptors whose meaning is more general than "N-Formylmethionine Leucyl-Phenylalanine".
Below are MeSH descriptors whose meaning is more specific than "N-Formylmethionine Leucyl-Phenylalanine".
This graph shows the total number of publications written about "N-Formylmethionine Leucyl-Phenylalanine" by people in this website by year, and whether "N-Formylmethionine Leucyl-Phenylalanine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1997 | 1 | 3 | 4 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 3 | 3 | | 2000 | 0 | 5 | 5 | | 2001 | 0 | 3 | 3 | | 2003 | 1 | 2 | 3 | | 2004 | 1 | 2 | 3 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 3 | 3 | | 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "N-Formylmethionine Leucyl-Phenylalanine" by people in Profiles.
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Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 05; 501(7465):52-7.
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Berry KA, Henson PM, Murphy RC. Effects of acrolein on leukotriene biosynthesis in human neutrophils. Chem Res Toxicol. 2008 Dec; 21(12):2424-32.
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Tuder RM, Yun JH, Graham BB. Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):1-6.
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Jordan JR, Moore EE, Sarin EL, Damle SS, Kashuk SB, Silliman CC, Banerjee A. Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4. J Appl Physiol (1985). 2008 Apr; 104(4):1161-6.
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Zemans R, Downey GP. Role of caveolin-1 in regulation of inflammation: different strokes for different folks. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L175-7.
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Eltzschig HK, Eckle T, Mager A, K?per N, Karcher C, Weissm?ller T, Boengler K, Schulz R, Robson SC, Colgan SP. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006 Nov 10; 99(10):1100-8.
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Zarini S, Gij?n MA, Folco G, Murphy RC. Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine. J Biol Chem. 2006 Apr 14; 281(15):10134-42.
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Tuluc F, Garcia A, Bredetean O, Meshki J, Kunapuli SP. Primary granule release from human neutrophils is potentiated by soluble fibrinogen through a mechanism depending on multiple intracellular signaling pathways. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1264-72.
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Di Gennaro A, Carnini C, Buccellati C, Ballerio R, Zarini S, Fumagalli F, Viappiani S, Librizzi L, Hernandez A, Murphy RC, Constantin G, De Curtis M, Folco G, Sala A. Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes. FASEB J. 2004 May; 18(7):842-4.
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Frasch SC, Henson PM, Nagaosa K, Fessler MB, Borregaard N, Bratton DL. Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils. J Biol Chem. 2004 Apr 23; 279(17):17625-33.
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