 Cathepsin D
"Cathepsin D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).
| Descriptor ID |
D002402
|
| MeSH Number(s) |
D08.811.277.656.074.500.180 D08.811.277.656.224.187 D08.811.277.656.300.048.180
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin D".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin D".
This graph shows the total number of publications written about "Cathepsin D" by people in this website by year, and whether "Cathepsin D" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 | | 2001 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Cathepsin D" by people in Profiles.
-
Crawford SA, Wiles TA, Wenzlau JM, Powell RL, Barbour G, Dang M, Groegler J, Barra JM, Burnette KS, Hohenstein AC, Baker RL, Tse HM, Haskins K, Delong T. Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes. Diabetes. 2022 12 01; 71(12):2793-2803.
-
Limonte CP, Valo E, Drel V, Natarajan L, Darshi M, Forsblom C, Henderson CM, Hoofnagle AN, Ju W, Kretzler M, Montemayor D, Nair V, Nelson RG, O'Toole JF, Toto RD, Rosas SE, Ruzinski J, Sandholm N, Schmidt IM, Vaisar T, Waikar SS, Zhang J, Rossing P, Ahluwalia TS, Groop PH, Pennathur S, Snell-Bergeon JK, Costacou T, Orchard TJ, Sharma K, de Boer IH. Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes. Diabetes Care. 2022 06 02; 45(6):1416-1427.
-
Baltazar GC, Guha S, Lu W, Lim J, Boesze-Battaglia K, Laties AM, Tyagi P, Kompella UB, Mitchell CH. Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells. PLoS One. 2012; 7(12):e49635.
-
Yu H, Zhou Y, Lind SE, Ding WQ. Clioquinol targets zinc to lysosomes in human cancer cells. Biochem J. 2009 Jan 01; 417(1):133-9.
-
Leinwand LA. Molecular events underlying pregnancy-induced cardiomyopathy. Cell. 2007 Feb 09; 128(3):437-8.
-
Bernard K, Litman E, Fitzpatrick JL, Shellman YG, Argast G, Polvinen K, Everett AD, Fukasawa K, Norris DA, Ahn NG, Resing KA. Functional proteomic analysis of melanoma progression. Cancer Res. 2003 Oct 15; 63(20):6716-25.
-
Ebert DH, Wetzel JD, Brumbaugh DE, Chance SR, Stobie LE, Baer GS, Dermody TS. Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3. J Virol. 2001 Apr; 75(7):3197-206.
-
Row PE, Reaves BJ, Domin J, Luzio JP, Davidson HW. Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Biochem J. 2001 Feb 01; 353(Pt 3):655-61.
-
Davidson HW. Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes. J Cell Biol. 1995 Aug; 130(4):797-805.
-
Makar R, Mason A, Kittelson JM, Bowden GT, Cress AE, Nagle RB. Immunohistochemical analysis of cathepsin D in prostate carcinoma. Mod Pathol. 1994 Sep; 7(7):747-51.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|