 Fas-Associated Death Domain Protein
"Fas-Associated Death Domain Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death effector domains found on INITIATOR CASPASES such as CASPASE 8 and CASPASE 10. Activation of CASPASES via interaction with this protein plays a role in the signaling cascade that leads to APOPTOSIS.
| Descriptor ID |
D053200
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| MeSH Number(s) |
D12.644.360.024.285.200 D12.644.360.024.500.124 D12.644.360.075.421.200 D12.776.157.057.018.200 D12.776.157.057.500.124 D12.776.476.024.320.550 D12.776.476.024.500.124 D12.776.476.075.421.200
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| Concept/Terms |
Fas-Associated Death Domain Protein- Fas-Associated Death Domain Protein
- Fas-Associating Protein with Death Domain
- Fas Associating Protein with Death Domain
- MORT1 Protein
- Fas Associated Death Domain Protein
- FADD Protein, Fas-Associating
- FADD Protein, Fas Associating
- Fas-Associating FADD Protein
- Fas-Associating Protein FADD
- FADD, Fas-Associating Protein
- Fas Associating Protein FADD
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Below are MeSH descriptors whose meaning is more general than "Fas-Associated Death Domain Protein".
Below are MeSH descriptors whose meaning is more specific than "Fas-Associated Death Domain Protein".
This graph shows the total number of publications written about "Fas-Associated Death Domain Protein" by people in this website by year, and whether "Fas-Associated Death Domain Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2009 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fas-Associated Death Domain Protein" by people in Profiles.
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Yamamoto TN, Lee PH, Vodnala SK, Gurusamy D, Kishton RJ, Yu Z, Eidizadeh A, Eil R, Fioravanti J, Gattinoni L, Kochenderfer JN, Fry TJ, Aksoy BA, Hammerbacher JE, Cruz AC, Siegel RM, Restifo NP, Klebanoff CA. T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy. J Clin Invest. 2019 02 25; 129(4):1551-1565.
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Lyttle B, Chai J, Gonzalez JM, Xu H, Sammel M, Elovitz MA. The negative regulators of the host immune response: an unexplored pathway in preterm birth. Am J Obstet Gynecol. 2009 Sep; 201(3):284.e1-7.
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Song JH, Kandasamy K, Kraft AS. ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis. J Biol Chem. 2008 Sep 05; 283(36):25003-13.
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Thomas LR, Bender LM, Morgan MJ, Thorburn A. Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5. Cell Death Differ. 2006 Jan; 13(1):160-2.
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Frankel SK, Cosgrove GP, Cha SI, Cool CD, Wynes MW, Edelman BL, Brown KK, Riches DW. TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):293-304.
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Thorburn J, Moore F, Rao A, Barclay WW, Thomas LR, Grant KW, Cramer SD, Thorburn A. Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol Biol Cell. 2005 Mar; 16(3):1189-99.
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Iordanov MS, Kirsch JD, Ryabinina OP, Wong J, Spitz PN, Korcheva VB, Thorburn A, Magun BE. Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs). Apoptosis. 2005 Jan; 10(1):167-76.
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Thomas LR, Johnson RL, Reed JC, Thorburn A. The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation. J Biol Chem. 2004 Dec 10; 279(50):52479-86.
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Thorburn J, Frankel AE, Thorburn A. Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein. Clin Cancer Res. 2003 Feb; 9(2):861-5.
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Thorburn J, Bender LM, Morgan MJ, Thorburn A. Caspase- and serine protease-dependent apoptosis by the death domain of FADD in normal epithelial cells. Mol Biol Cell. 2003 Jan; 14(1):67-77.
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