 Integrin alpha2beta1
"Integrin alpha2beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
| Descriptor ID |
D038982
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| MeSH Number(s) |
D12.776.395.550.625.298 D12.776.543.550.625.298 D12.776.543.750.685.200 D12.776.543.750.705.408.530.249 D12.776.543.750.705.408.850.199 D12.776.543.750.705.675.352 D12.776.543.750.705.876.280
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| Concept/Terms |
Integrin alpha2beta1- Integrin alpha2beta1
- alpha2beta1, Integrin
- VLA-2
- VLA 2
- Glycoprotein Ia-IIa
- Glycoprotein Ia IIa
- alpha2beta1Integrin
- Very Late Antigen-2
- Late Antigen-2, Very
- Very Late Antigen 2
- CD49b-CD29
- CD49b CD29
- Platelet Membrane Glycoprotein Heterodimer Ia-IIa
- Platelet Membrane Glycoprotein Heterodimer Ia IIa
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Below are MeSH descriptors whose meaning is more general than "Integrin alpha2beta1".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha2beta1".
This graph shows the total number of publications written about "Integrin alpha2beta1" by people in this website by year, and whether "Integrin alpha2beta1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha2beta1" by people in Profiles.
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Hu H, Li D, Liu S, Wang M, Moats R, Conti PS, Li Z. Integrin a2?1 targeted GdVO4:Eu ultrathin nanosheet for multimodal PET/MR imaging. Biomaterials. 2014 Oct; 35(30):8649-58.
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Sottnik JL, Daignault-Newton S, Zhang X, Morrissey C, Hussain MH, Keller ET, Hall CL. Integrin alpha2beta 1 (a2?1) promotes prostate cancer skeletal metastasis. Clin Exp Metastasis. 2013 Jun; 30(5):569-78.
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Huang CW, Li Z, Conti PS. In vivo near-infrared fluorescence imaging of integrin a2?1 in prostate cancer with cell-penetrating-peptide-conjugated DGEA probe. J Nucl Med. 2011 Dec; 52(12):1979-86.
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Banerjee A, Kim BJ, Carmona EM, Cutting AS, Gurney MA, Carlos C, Feuer R, Prasadarao NV, Doran KS. Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration. Nat Commun. 2011 Sep 06; 2:462.
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Huang CW, Li Z, Cai H, Shahinian T, Conti PS. Novel a(2)?(1) integrin-targeted peptide probes for prostate cancer imaging. Mol Imaging. 2011 Aug; 10(4):284-94.
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Huang CW, Li Z, Cai H, Chen K, Shahinian T, Conti PS. Design, synthesis and validation of integrin a2?1-targeted probe for microPET imaging of prostate cancer. Eur J Nucl Med Mol Imaging. 2011 Jul; 38(7):1313-22.
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Huang CW, Li Z, Cai H, Shahinian T, Conti PS. Biological stability evaluation of the a2?1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide. Bioconjug Chem. 2011 Feb 16; 22(2):256-63.
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Neeves KB, Maloney SF, Fong KP, Schmaier AA, Kahn ML, Brass LF, Diamond SL. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thromb Haemost. 2008 Dec; 6(12):2193-201.
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