 Integrin alpha4beta1
"Integrin alpha4beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
| Descriptor ID |
D039041
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| MeSH Number(s) |
D12.776.395.550.200.625.347 D12.776.543.550.200.625.347 D12.776.543.750.705.408.530.500 D12.776.543.750.705.408.850.299 D12.776.543.750.705.877.347 D23.050.301.350.625.347
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| Concept/Terms |
Integrin alpha4beta1- Integrin alpha4beta1
- alpha4beta1, Integrin
- VLA-4
- Integrin alpha(4)beta(1)
- alpha4beta1 Integrin
- Integrin, alpha4beta1
- Very Late Activation Antigen-4
- Very Late Activation Antigen 4
- Very Late Antigen-4
- Antigen-4, Very Late
- Late Antigen-4, Very
- Very Late Antigen 4
- CD49d-CD29
- Integrin Heterodimer alpha4beta1
- Heterodimer alpha4beta1, Integrin
- alpha4beta1, Integrin Heterodimer
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Below are MeSH descriptors whose meaning is more general than "Integrin alpha4beta1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Cell Adhesion Molecules [D12.776.395.550.200]
- Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
- Integrin alpha4beta1 [D12.776.395.550.200.625.347]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Cell Adhesion Molecules [D12.776.543.550.200]
- Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
- Integrin alpha4beta1 [D12.776.543.550.200.625.347]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Integrins [D12.776.543.750.705.408]
- Receptors, Fibronectin [D12.776.543.750.705.408.530]
- Integrin alpha4beta1 [D12.776.543.750.705.408.530.500]
- Receptors, Very Late Antigen [D12.776.543.750.705.408.850]
- Integrin alpha4beta1 [D12.776.543.750.705.408.850.299]
- Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
- Integrin alpha4beta1 [D12.776.543.750.705.877.347]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Cell Adhesion Molecules [D23.050.301.350]
- Receptors, Lymphocyte Homing [D23.050.301.350.625]
- Integrin alpha4beta1 [D23.050.301.350.625.347]
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha4beta1".
This graph shows the total number of publications written about "Integrin alpha4beta1" by people in this website by year, and whether "Integrin alpha4beta1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Integrin alpha4beta1" by people in Profiles.
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Banerjee A, Wang J, Bodhankar S, Vandenbark AA, Murphy SJ, Offner H. Phenotypic changes in immune cell subsets reflect increased infarct volume in male vs. female mice. Transl Stroke Res. 2013 Oct; 4(5):554-63.
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Warnke C, Menge T, Hartung HP, Racke MK, Cravens PD, Bennett JL, Frohman EM, Greenberg BM, Zamvil SS, Gold R, Hemmer B, Kieseier BC, St?ve O. Natalizumab and progressive multifocal leukoencephalopathy: what are the causal factors and can it be avoided? Arch Neurol. 2010 Aug; 67(8):923-30.
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Parmley LA, Elkins ND, Fini MA, Liu YE, Repine JE, Wright RM. Alpha-4/beta-1 and alpha-L/beta-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury. Br J Pharmacol. 2007 Nov; 152(6):915-29.
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Bennett JL. Natalizumab and progressive multifocal leukoencephalopathy: migrating towards safe adhesion molecule therapy in multiple sclerosis. Neurol Res. 2006 Apr; 28(3):291-8.
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Sheremata WA, Minagar A, Alexander JS, Vollmer T. The role of alpha-4 integrin in the aetiology of multiple sclerosis: current knowledge and therapeutic implications. CNS Drugs. 2005; 19(11):909-22.
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Gismondi A, Jacobelli J, Strippoli R, Mainiero F, Soriani A, Cifaldi L, Piccoli M, Frati L, Santoni A. Proline-rich tyrosine kinase 2 and Rac activation by chemokine and integrin receptors controls NK cell transendothelial migration. J Immunol. 2003 Mar 15; 170(6):3065-73.
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Costello RW, Evans CM, Yost BL, Belmonte KE, Gleich GJ, Jacoby DB, Fryer AD. Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils. Am J Physiol. 1999 05; 276(5):L709-14.
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Shima M, Teitelbaum SL, Holers VM, Ruzicka C, Osmack P, Ross FP. Macrophage-colony-stimulating factor regulates expression of the integrins alpha 4 beta 1 and alpha 5 beta 1 by murine bone marrow macrophages. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):5179-83.
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