 Integrin alpha6beta4
"Integrin alpha6beta4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
| Descriptor ID |
D039161
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| MeSH Number(s) |
D12.776.543.750.705.408.460.170 D12.776.543.750.705.876.750
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| Concept/Terms |
Integrin alpha6beta4- Integrin alpha6beta4
- alpha6beta4, Integrin
- alpha(6)beta(4) Integrin
- alpha6 beta4 Integrin
- Integrin, alpha6 beta4
- beta4 Integrin, alpha6
- Integrin alpha(6),beta(4)
- A9 Antigen
- Antigen, A9
- TSP-180
- Tumor Specific Protein-180 Complex
- Tumor Specific Protein 180 Complex
- alpha(6)beta(4) Epithelial Integrin
- Laminin-5 Receptor (alpha6beta4 Integrin)
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Below are MeSH descriptors whose meaning is more general than "Integrin alpha6beta4".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6beta4".
This graph shows the total number of publications written about "Integrin alpha6beta4" by people in this website by year, and whether "Integrin alpha6beta4" was a major or minor topic of these publications.
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Below are the most recent publications written about "Integrin alpha6beta4" by people in Profiles.
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Sehgal BU, DeBiase PJ, Matzno S, Chew TL, Claiborne JN, Hopkinson SB, Russell A, Marinkovich MP, Jones JC. Integrin beta4 regulates migratory behavior of keratinocytes by determining laminin-332 organization. J Biol Chem. 2006 Nov 17; 281(46):35487-98.
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Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. J Cell Biol. 2003 Dec 22; 163(6):1397-407.
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Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J Cell Sci. 2003 Sep 01; 116(Pt 17):3543-56.
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Dajee M, Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ, Marinkovich MP, Tao S, Lin Q, Kubo Y, Khavari PA. NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature. 2003 Feb 06; 421(6923):639-43.
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Borradori L, Koch PJ, Niessen CM, Erkeland S, van Leusden MR, Sonnenberg A. The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit. J Cell Biol. 1997 Mar 24; 136(6):1333-47.
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