 Tryptophan
"Tryptophan" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
| Descriptor ID |
D014364
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| MeSH Number(s) |
D12.125.072.050.850 D12.125.142.875
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| Concept/Terms |
Tryptophan- Tryptophan
- L-Tryptophan
- L Tryptophan
- Levotryptophan
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Below are MeSH descriptors whose meaning is more general than "Tryptophan".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan".
This graph shows the total number of publications written about "Tryptophan" by people in this website by year, and whether "Tryptophan" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 1 | 1 | 2 | | 1998 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 3 | 3 | | 2002 | 1 | 1 | 2 | | 2005 | 0 | 7 | 7 | | 2006 | 6 | 5 | 11 | | 2007 | 0 | 2 | 2 | | 2008 | 2 | 2 | 4 | | 2009 | 0 | 2 | 2 | | 2010 | 3 | 3 | 6 | | 2011 | 2 | 2 | 4 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 4 | 4 | | 2014 | 2 | 1 | 3 | | 2015 | 0 | 1 | 1 | | 2016 | 3 | 0 | 3 | | 2017 | 3 | 1 | 4 | | 2018 | 2 | 1 | 3 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 4 | 6 | | 2021 | 1 | 3 | 4 | | 2022 | 1 | 3 | 4 | | 2023 | 1 | 1 | 2 | | 2024 | 4 | 3 | 7 | | 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tryptophan" by people in Profiles.
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Dylla L, Reisz JA, Poisson SN, Herson PS, Sansing LH, Monte AA. Elevated initial blood kynurenine is associated with increased odds of post-stroke infection: Kynurenine and post-stroke infection. J Stroke Cerebrovasc Dis. 2025 May; 34(5):108268.
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Dylla L, Higgins HM, Poisson SN, Vu T, Reisz JA, Herson PS, Monte A. Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke. Clin Ther. 2024 Dec; 46(12):960-966.
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Romanowicz J, Niemiec S, Khailova L, Lehmann T, Mancuso CA, Mitchell MB, Morgan GJ, Twite M, DiMaria MV, Klawitter J, Davidson JA, Frank BS. Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease. Physiol Rep. 2024 Nov; 12(22):e70133.
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Kuo LW, Crump LS, O'Neill K, Williams MM, Christenson JL, Spoelstra NS, Roy MK, Argabright A, Reisz JA, D'Alessandro A, Boorgula MP, Goodspeed A, Bickerdike M, Bitler BG, Richer JK. Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity. Cancer Res Commun. 2024 10 01; 4(10):2699-2713.
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Bohn B, Tilves C, Chen Y, Doyon M, Bouchard L, Perron P, Gu?rin R, Mass? ?, Hivert MF, Mueller NT. Associations of gut microbiota features and circulating metabolites with systemic inflammation in children. BMJ Open Gastroenterol. 2024 Aug 29; 11(1).
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Sugino KY, Janssen RC, McMahan RH, Zimmerman C, Friedman JE, Jonscher KR. Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response. Nutrients. 2024 Jun 08; 16(12).
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Crump LS, Floyd JL, Kuo LW, Post MD, Bickerdike M, O'Neill K, Sompel K, Jordan KR, Corr BR, Marjon N, Woodruff ER, Richer JK, Bitler BG. Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression. Cancer Res Commun. 2024 03 18; 4(3):822-833.
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Johnson TS, MacDonald TJ, Pacholczyk R, Aguilera D, Al-Basheer A, Bajaj M, Bandopadhayay P, Berrong Z, Bouffet E, Castellino RC, Dorris K, Eaton BR, Esiashvili N, Fangusaro JR, Foreman N, Fridlyand D, Giller C, Heger IM, Huang C, Kadom N, Kennedy EP, Manoharan N, Martin W, McDonough C, Parker RS, Ramaswamy V, Ring E, Rojiani A, Sadek RF, Satpathy S, Schniederjan M, Smith A, Smith C, Thomas BE, Vaizer R, Yeo KK, Bhasin MK, Munn DH. Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial. Neuro Oncol. 2024 02 02; 26(2):348-361.
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Seymour BJ, Trent B, Allen BE, Berlinberg AJ, Tangchittsumran J, Jubair WK, Chriswell ME, Liu S, Ornelas A, Stahly A, Alexeev EE, Dowdell AS, Sneed SL, Fechtner S, Kofonow JM, Robertson CE, Dillon SM, Wilson CC, Anthony RM, Frank DN, Colgan SP, Kuhn KA. Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice. J Clin Invest. 2023 Dec 19; 134(4).
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Nguyen DT, Kleczko EK, Dwivedi N, Monaghan MT, Gitomer BY, Chonchol MB, Clambey ET, Nemenoff RA, Klawitter J, Hopp K. The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression. JCI Insight. 2023 01 10; 8(1).
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