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Benjamin Steven Frank

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

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    K23HL163490     (FRANK, BENJAMIN S)Jan 1, 2023 - Dec 31, 2027
    NIH
    Pulmonary Vascular Development in Single Ventricle Heart Disease: A Longitudinal Biomarker Approach
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Iguidbashian J, Malone LJ, Browne LP, Nguyen M, Frank B, Schafer M, Campbell DN, Mitchell MB, Jaggers J, Stone ML. Regional Arch Measurements Differ Between Imaging Modalities in Infants With Aortic Coarctation. Ann Thorac Surg. 2024 Jul; 118(1):209-215. PMID: 38072352.
      View in: PubMed
    2. Thomson LM, Mancuso CA, Wolfe KR, Khailova L, Niemiec S, Ali E, DiMaria M, Mitchell M, Twite M, Morgan G, Frank BS, Davidson JA. The proteomic fingerprint in infants with single ventricle heart disease in the interstage period: evidence of chronic inflammation and widespread activation of biological networks. Front Pediatr. 2023; 11:1308700. PMID: 38143535.
      View in: PubMed
    3. Frank BS, Nandy D, Khailova L, Mitchell MB, Morgan GJ, Twite M, DiMaria MV, Davidson JA. Circulating biomarkers of extracellular matrix dysregulation are associated with adverse post-stage 2 outcomes in infants with single ventricle heart disease. Sci Rep. 2023 09 28; 13(1):16318. PMID: 37770592.
      View in: PubMed
    4. Subhedar NV, Frank B, Abman SH. Better Survival with Less Morbidity in Extremely Preterm Infants: Attacking the Heart of the Matter. Am J Respir Crit Care Med. 2023 08 01; 208(3):228-229. PMID: 37348107.
      View in: PubMed
    5. Ali EA, Syed A, Khailova L, Iguidbashian JP, Suarez-Pierre A, Klawitter J, Stone M, Mancuso CA, Frank BS, Davidson JA. Novel Biomarkers of Necrotizing Enterocolitis in Neonates Undergoing Congenital Heart Disease Surgery: A Pilot Cohort Study. J Am Heart Assoc. 2023 08; 12(15):e030712. PMID: 37489765.
      View in: PubMed
    6. Sch?fer M, Mitchell MB, Frank BS, Barker AJ, Stone ML, Jaggers J, von Alvensleben JC, Hunter KS, Friesen RM, Ivy DD, Jacobsen R, Di Maria MV. Myocardial strain-curve deformation patterns after Fontan operation. Sci Rep. 2023 07 24; 13(1):11912. PMID: 37488167.
      View in: PubMed
    7. Ta HT, Critser PJ, Sch?fer M, Ollberding NJ, Taylor MD, Di Maria MV, Hirsch R, Ivy DD, Frank BS. Ventricular global function index is associated with clinical outcomes in pediatric pulmonary hypertension. J Cardiovasc Magn Reson. 2023 07 03; 25(1):39. PMID: 37400886.
      View in: PubMed
    8. Le LS, Kinsella JP, Gien J, Frank BS. Failure to Normalize Biventricular Function Is Associated with Extracorporeal Membrane Oxygenation Use in Neonates with Congenital Diaphragmatic Hernia. J Pediatr. 2023 09; 260:113490. PMID: 37201678.
      View in: PubMed
    9. O'Callaghan B, Zablah JE, Weinman JP, Englund EK, Morgan GJ, Ivy DD, Frank BS, Mong DA, Malone LJ, Browne LP. Computed tomographic parenchymal lung findings in premature infants with pulmonary vein stenosis. Pediatr Radiol. 2023 08; 53(9):1874-1884. PMID: 37106091.
      View in: PubMed
    10. Frank BS, Khailova L, Dekermanjian J, Mitchell MB, Morgan GJ, Twite M, Christians U, DiMaria MV, Klawitter J, Davidson JA. Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways: Targeted Metabolomics Analysis. JACC Adv. 2023 Jan; 2(1). PMID: 36875009.
      View in: PubMed
    11. Maia PD, Gien J, Kinsella JP, Zablah J, Morgan G, Ivy DD, Abman SH, Frank BS. Hemodynamic Characterization of Neonates With Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension by Cardiac Catheterization. J Pediatr. 2023 04; 255:230-235.e2. PMID: 36463937.
      View in: PubMed
    12. Domingo LT, Ivy DD, Abman SH, Grenolds AM, MacLean JT, Breaux JA, Minford KJ, Frank BS. Novel use of riociguat in infants with severe pulmonary arterial hypertension unable to wean from inhaled nitric oxide. Front Pediatr. 2022; 10:1014922. PMID: 36533232.
      View in: PubMed
    13. Stone ML, Sch?fer M, von Alvensleben JC, Frank BS, Campbell DN, Mitchell MB, Jaggers J. Left Ventricular Dysfunction Following the Ross-Konno Reconstruction is Independent of the Operation. Pediatr Cardiol. 2023 Feb; 44(2):463-471. PMID: 36370189.
      View in: PubMed
    14. Quinn LA, Gilley SP, Ta AD, Frank BS, Foley CB, Moore JM. Case report: Pulmonary hypertensive crisis leading to cardiac arrest during endoscopic evaluation in a 6-year-old boy with autism, severe malnutrition, and undiagnosed scurvy. Front Pediatr. 2022; 10:1008507. PMID: 36389378.
      View in: PubMed
    15. Evers PD, Quinn P, Critser PJ, Frank BS, Alnoor M, Armsby LB. Prognostic value of longitudinal vasoreactivity in pediatric pulmonary hypertension. Pulm Circ. 2022 Oct; 12(4):e12152. PMID: 36381291.
      View in: PubMed
    16. Davidson JA, Robison J, Khailova L, Frank BS, Jaggers J, Ing RJ, Lawson S, Iguidbashian J, Ali E, Treece A, Soranno DE, Osorio-Lujan S, Klawitter J. Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury. Am J Physiol Renal Physiol. 2022 07 01; 323(1):F20-F32. PMID: 35532069.
      View in: PubMed
    17. Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, DiMaria MV, Davidson JA. Increased Circulating Endothelin 1 Is Associated With Postoperative Hypoxemia in Infants With Single-Ventricle Heart Disease Undergoing Superior Cavopulmonary Anastomosis. J Am Heart Assoc. 2022 03 15; 11(6):e024007. PMID: 35243904.
      View in: PubMed
    18. Sch?fer M, Frank BS, Ivy DD, Mitchell MB, Collins KK, Jone PN, von Alvensleben JC. Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension. J Am Heart Assoc. 2022 03 15; 11(6):e024787. PMID: 35229614.
      View in: PubMed
    19. Issapour A, Frank B, Crook S, Hite MD, Dorn ML, Rosenzweig EB, Ivy DD, Krishnan US. Safety and tolerability of combination therapy with ambrisentan and tadalafil for the treatment of pulmonary arterial hypertension in children: Real-world experience. Pediatr Pulmonol. 2022 03; 57(3):724-733. PMID: 34921523.
      View in: PubMed
    20. Sch?fer M, Frank BS, Grady RM, Eghtesady P, Mitchell MB, Jaggers J, Ivy DD. Monitoring and evaluation of the surgical Potts shunt physiology using 4-dimensional flow magnetic resonance imaging. J Thorac Cardiovasc Surg. 2022 08; 164(2):331-341. PMID: 34872760.
      View in: PubMed
    21. Cooney SJ, Klawitter J, Khailova L, Robison J, Jaggers J, Ing RJ, Lawson S, Frank BS, Lujan SO, Davidson JA. Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest. Metabolomics. 2021 09 22; 17(10):89. PMID: 34553313.
      View in: PubMed
    22. Bloom JL, Frank B, Weinman JP, Galambos C, O'Leary ST, Liptzin DR, Fuhlbrigge RC. Diffuse alveolar hemorrhage in children with trisomy 21. Pediatr Rheumatol Online J. 2021 Jul 17; 19(1):114. PMID: 34273981.
      View in: PubMed
    23. Sch?fer M, Ivy DD, Nguyen K, Boncella K, Frank BS, Morgan GJ, Miller-Reed K, Truong U, Colvin K, Yeager ME. Metalloproteinases and their inhibitors are associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H242-H252. PMID: 34085841.
      View in: PubMed
    24. Oganesyan A, Hoffner-Heinike A, Barker AJ, Frank BS, Ivy DD, Hunter KS, Mitchell MB, Humphries SM, Fenster BE, Sch?fer M. Abnormal pulmonary flow is associated with impaired right ventricular coupling in patients with COPD. Int J Cardiovasc Imaging. 2021 Oct; 37(10):3039-3048. PMID: 34021434.
      View in: PubMed
    25. Davidson JA, Frank BS, Urban TT, Twite M, Jaggers J, Khailova L, Klawitter J. Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatr Nephrol. 2021 10; 36(10):3259-3269. PMID: 33954809.
      View in: PubMed
    26. Sch?fer M, Frank BS, Ivy DD, Abman SH, Stenmark KR, Mitchell MB, Browne LP, Barker AJ, Hunter KS, Kheyfets V, Miller-Reed K, Ing R, Morgan GJ, Truong U. Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension. J Am Heart Assoc. 2021 04 20; 10(8):e020548. PMID: 33821682.
      View in: PubMed
    27. Frank BS, Sch?fer M, Thomas TM, Ivy DD, Jone PN. Longitudinal assessment of right atrial conduit fraction provides additional insight to predict adverse events in pediatric pulmonary hypertension. Int J Cardiol. 2021 04 15; 329:242-245. PMID: 33400972.
      View in: PubMed
    28. Ivy D, Frank BS. Update on pediatric pulmonary arterial hypertension. Curr Opin Cardiol. 2021 01; 36(1):67-79. PMID: 33136663.
      View in: PubMed
    29. Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2021 03; 229:24-37. PMID: 33045409.
      View in: PubMed
    30. Frank BS, Ivy DD. Pediatric Pulmonary Arterial Hypertension. Pediatr Clin North Am. 2020 10; 67(5):903-921. PMID: 32888689.
      View in: PubMed
    31. Das BB, Frank B, Ivy D. Segmental Pulmonary Hypertension in Children with Congenital Heart Disease. Medicina (Kaunas). 2020 Sep 24; 56(10). PMID: 32987636.
      View in: PubMed
    32. Pagano E, Frank B, Jaggers J, Twite M, Urban TT, Klawitter J, Davidson J. Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease. Congenit Heart Dis. 2020 Sep 07; 15(4):251-265. PMID: 34413893.
      View in: PubMed
    33. Sabapathy D, Klawitter J, Silveira L, Khailova L, Mitchell MB, Morgan GJ, DiMaria MV, Twite M, Frank BS, Davidson JA. Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study. Metabolomics. 2020 09 05; 16(9):93. PMID: 32889608.
      View in: PubMed
    34. Sch?fer M, Frank BS, Jacobsen R, Rausch CM, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Browne LP, Barker AJ, Hunter KS, Ivy DD, Younoszai A, Di Maria MV. Patients with Fontan circulation have abnormal aortic wave propagation patterns: A wave intensity analysis study. Int J Cardiol. 2021 01 01; 322:158-167. PMID: 32853667.
      View in: PubMed
    35. Sch?fer M, Bjornstad P, Frank BS, Baumgartner A, Truong U, Enge D, von Alvensleben JC, Mitchell MB, Ivy DD, Barker AJ, Reusch JEB, Nadeau KJ. Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study). Am J Cardiol. 2020 08 01; 128:45-53. PMID: 32650923.
      View in: PubMed
    36. Frank BS, Schafer M, Thomas TM, Haxel C, Ivy DD, Jone PN. Right Atrial Conduit Phase Emptying Predicts Risk of Adverse Events in Pediatric Pulmonary Arterial Hypertension. J Am Soc Echocardiogr. 2020 08; 33(8):1006-1013. PMID: 32336608.
      View in: PubMed
    37. Sch?fer M, Frank BS, Humphries SM, Hunter KS, Carmody KL, Jacobsen R, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Barker AJ, Browne LP, Ivy DD, Younoszai A, Di Maria MV. Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study. Am J Physiol Heart Circ Physiol. 2020 05 01; 318(5):H1032-H1040. PMID: 32167782.
      View in: PubMed
    38. Frank BS, Sch?fer M, Douwes JM, Ivy DD, Abman SH, Davidson JA, Burzlaff S, Mitchell MB, Morgan GJ, Browne LP, Barker AJ, Truong U, von Alvensleben JC. Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2020 02 01; 318(2):H401-H412. PMID: 31858817.
      View in: PubMed
    39. Frank BS, Sch?fer M, Grenolds A, Ivy DD, Abman SH, Darst JR. Acute Vasoreactivity Testing during Cardiac Catheterization of Neonates with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. J Pediatr. 2019 05; 208:127-133. PMID: 30871795.
      View in: PubMed
    40. Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Sim?es EAF, Wischmeyer P. Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery. Shock. 2019 03; 51(3):328-336. PMID: 29664834.
      View in: PubMed
    41. Frank BS, Runciman M, Manning WA, Ivy DD, Abman SH, Howley L. Pulmonary Hypertension Secondary to Scurvy in a Developmentally Typical Child. J Pediatr. 2019 May; 208:291-291.e2. PMID: 30738657.
      View in: PubMed
    42. Frank BS, Urban TT, Lewis K, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta. Congenit Heart Dis. 2019 May; 14(3):446-453. PMID: 30650250.
      View in: PubMed
    43. Davidson JA, Pfeifer Z, Frank B, Tong S, Urban TT, Wischmeyer PA, Mourani P, Landeck B, Christians U, Klawitter J. Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. J Am Heart Assoc. 2018 12 18; 7(24):e010711. PMID: 30561257.
      View in: PubMed
    44. Sch?fer M, Frank BS, Ivy DD, Wilson N, Morgan GJ, Barker AJ, Browne LP, Mitchell MB, Truong U. Close look at the Potts shunt flow hemodynamics in a patient with severe pulmonary hypertension: 4D-flow MRI evaluation. J Magn Reson Imaging. 2019 06; 49(6):1800-1802. PMID: 30451346.
      View in: PubMed
    45. Frank BS, Ivy DD. Diagnosis, Evaluation and Treatment of Pulmonary Arterial Hypertension in Children. Children (Basel). 2018 Mar 23; 5(4). PMID: 29570688.
      View in: PubMed
    46. Sch?fer M, Collins KK, Browne LP, Ivy DD, Abman S, Friesen R, Frank B, Fonseca B, DiMaria M, Hunter KS, Truong U, von Alvensleben JC. Effect of electrical dyssynchrony on left and right ventricular mechanics in children with pulmonary arterial hypertension. J Heart Lung Transplant. 2018 07; 37(7):870-878. PMID: 29496397.
      View in: PubMed
    47. Frank BS, Urban TT, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair. World J Cardiol. 2017 Dec 26; 9(12):822-829. PMID: 29317988.
      View in: PubMed
    48. Frank B, Davidson J, Tong S, Martin B, Heizer H, Anderson MS, Glode MP, Dominguez SR, Jone PN. Myocardial Strain and Strain Rate in Kawasaki Disease: Range, Recovery, and Relationship to Systemic Inflammation/Coronary Artery Dilation. J Clin Exp Cardiolog. 2016 Apr; 7(4). PMID: 27182455.
      View in: PubMed
    49. Thornton RH, Frank BS, Covey AM, Maybody M, Solomon SB, Getrajdman GI, Brown KT. Catheter-free survival after primary percutaneous stenting of malignant bile duct obstruction. AJR Am J Roentgenol. 2011 Sep; 197(3):W514-8. PMID: 21862781.
      View in: PubMed
    50. Frank BS, Toth PB, Wells WK, McFall CR, Cromwell ML, Hilbert SL, Lofland GK, Hopkins RA. Determining cell seeding dosages for tissue engineering human pulmonary valves. J Surg Res. 2012 May 01; 174(1):39-47. PMID: 21345451.
      View in: PubMed
    51. Chubinskaya S, Frank BS, Michalska M, Kumar B, Merrihew CA, Thonar EJ, Lenz ME, Otten L, Rueger DC, Block JA. Osteogenic protein 1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: relationship with disease and levels of hyaluronan and antigenic keratan sulfate. Arthritis Res Ther. 2006; 8(3):R73. PMID: 16646979.
      View in: PubMed
    52. Frank BS, Vardar D, Chishti AH, McKnight CJ. The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site. J Biol Chem. 2004 Feb 27; 279(9):7909-16. PMID: 14660664.
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    53. Vardar D, Buckley DA, Frank BS, McKnight CJ. NMR structure of an F-actin-binding "headpiece" motif from villin. J Mol Biol. 1999 Dec 17; 294(5):1299-310. PMID: 10600386.
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    54. Frank BS, Lewis RJ. Experience with intubated patients does not affect the accidental extubation rate in pediatric intensive care units and intensive care nurseries. Pediatr Pulmonol. 1997 Jun; 23(6):424-8. PMID: 9220524.
      View in: PubMed
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