 Cystathionine gamma-Lyase
"Cystathionine gamma-Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.
| Descriptor ID |
D003542
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| MeSH Number(s) |
D08.811.520.300.250
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| Concept/Terms |
Cystathionine gamma-Lyase- Cystathionine gamma-Lyase
- Cystathionine gamma Lyase
- gamma-Lyase, Cystathionine
- Cystine Desulfhydrase
- Desulfhydrase, Cystine
- Cysteine Desulfhydrase
- Desulfhydrase, Cysteine
- gamma-Cystathionase
- gamma Cystathionase
- Homoserine Deaminase
- Deaminase, Homoserine
- Homoserine Dehydratase
- Dehydratase, Homoserine
- Cystathionase
- Cystine Desulfohydrolase
- Desulfohydrolase, Cystine
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Below are MeSH descriptors whose meaning is more general than "Cystathionine gamma-Lyase".
Below are MeSH descriptors whose meaning is more specific than "Cystathionine gamma-Lyase".
This graph shows the total number of publications written about "Cystathionine gamma-Lyase" by people in this website by year, and whether "Cystathionine gamma-Lyase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cystathionine gamma-Lyase" by people in Profiles.
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Bithi N, Link C, Henderson YO, Kim S, Yang J, Li L, Wang R, Willard B, Hine C. Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine ?-lyase-dependent manner. Nat Commun. 2021 03 19; 12(1):1745.
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Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 04; 40:101827.
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Guerra DD, Bok R, Breen K, Vyas V, Jiang H, MacLean KN, Hurt KJ. Estrogen Regulates Local Cysteine Metabolism in Mouse Myometrium. Reprod Sci. 2021 01; 28(1):79-90.
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Dickhout JG, Carlisle RE, Jerome DE, Mohammed-Ali Z, Jiang H, Yang G, Mani S, Garg SK, Banerjee R, Kaufman RJ, Maclean KN, Wang R, Austin RC. Integrated stress response modulates cellular redox state via induction of cystathionine ?-lyase: cross-talk between integrated stress response and thiol metabolism. J Biol Chem. 2012 Mar 02; 287(10):7603-14.
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Kraus JP, Hasek J, Kozich V, Collard R, Venezia S, Janos?kov? B, Wang J, Stabler SP, Allen RH, Jakobs C, Finn CT, Chien YH, Hwu WL, Hegele RA, Mudd SH. Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies. Mol Genet Metab. 2009 Aug; 97(4):250-9.
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Pong WW, Stouracova R, Frank N, Kraus JP, Eldred WD. Comparative localization of cystathionine beta-synthase and cystathionine gamma-lyase in retina: differences between amphibians and mammals. J Comp Neurol. 2007 Nov 10; 505(2):158-65.
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Look MP, Riezler R, Reichel C, Brensing KA, Rockstroh JK, Stabler SP, Spengler U, Berthold HK, Sauerbruch T. Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of gamma-cystathionase? Scand J Gastroenterol. 2000 Aug; 35(8):866-72.
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Rusakow LS, White CW, Stabler SP. O2-induced changes in lung and storage pool thiols in mice: effect of superoxide dismutase. J Appl Physiol (1985). 1993 Mar; 74(3):989-97.
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Erickson PF, Maxwell IH, Su LJ, Baumann M, Glode LM. Sequence of cDNA for rat cystathionine gamma-lyase and comparison of deduced amino acid sequence with related Escherichia coli enzymes. Biochem J. 1990 Jul 15; 269(2):335-40.
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Klein CE, Roberts B, Holcenberg J, Glode LM. Cystathionine metabolism in neuroblastoma. Cancer. 1988 Jul 15; 62(2):291-8.
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