 Lactoylglutathione Lyase
"Lactoylglutathione Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5.
| Descriptor ID |
D007791
|
| MeSH Number(s) |
D08.811.520.300.500
|
| Concept/Terms |
Lactoylglutathione Lyase- Lactoylglutathione Lyase
- Lyase, Lactoylglutathione
- Methylglyoxalase
- Glyoxalase I
- Lactoyl Glutathione Lyase
- Glutathione Lyase, Lactoyl
- Lyase, Lactoyl Glutathione
|
Below are MeSH descriptors whose meaning is more general than "Lactoylglutathione Lyase".
Below are MeSH descriptors whose meaning is more specific than "Lactoylglutathione Lyase".
This graph shows the total number of publications written about "Lactoylglutathione Lyase" by people in this website by year, and whether "Lactoylglutathione Lyase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2024 | 1 | 0 | 1 | | 2025 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Lactoylglutathione Lyase" by people in Profiles.
-
Trujillo MN, Jennings EQ, Farrera DO, Kitamura N, Anderson CC, Gehrke S, Reisz JA, Johannsen M, Roede JR, D'Alessandro A, Galligan JJ. Glyoxalase 2 Coordinates de Novo Serine Metabolism. Chembiochem. 2025 Apr 01; 26(7):e202401086.
-
Akbari MS, Joyce LR, Spencer BL, Brady A, McIver KS, Doran KS. Identification of glyoxalase A in group B Streptococcus and its contribution to methylglyoxal tolerance and virulence. Infect Immun. 2025 Apr 08; 93(4):e0054024.
-
Trujillo MN, Jennings EQ, Hoffman EA, Zhang H, Phoebe AM, Mastin GE, Kitamura N, Reisz JA, Megill E, Kantner D, Marcinkiewicz MM, Twardy SM, Lebario F, Chapman E, McCullough RL, D'Alessandro A, Snyder NW, Cusanovich DA, Galligan JJ. Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation. Mol Metab. 2024 Mar; 81:101888.
-
Gaffney DO, Jennings EQ, Anderson CC, Marentette JO, Shi T, Schou Oxvig AM, Streeter MD, Johannsen M, Spiegel DA, Chapman E, Roede JR, Galligan JJ. Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes. Cell Chem Biol. 2020 02 20; 27(2):206-213.e6.
-
Mailankot M, Padmanabha S, Pasupuleti N, Major D, Howell S, Nagaraj RH. Glyoxalase I activity and immunoreactivity in the aging human lens. Biogerontology. 2009 Dec; 10(6):711-20.
-
Padival S, Nagaraj RH. Pyridoxamine inhibits maillard reactions in diabetic rat lenses. Ophthalmic Res. 2006; 38(5):294-302.
-
Staniszewska MM, Nagaraj RH. Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses. Mol Cell Biochem. 2006 Aug; 288(1-2):29-36.
-
Nagaraj RH, Sarkar P, Mally A, Biemel KM, Lederer MO, Padayatti PS. Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal. Arch Biochem Biophys. 2002 Jun 01; 402(1):110-9.
-
Shamsi FA, Sharkey E, Creighton D, Nagaraj RH. Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens. Exp Eye Res. 2000 Mar; 70(3):369-80.
-
Leinwand L, Nichols E, Ruddle FH. Assignment of the gene for glyoxylase I to mouse chromosome 17 by somatic cell genetics. Biochem Genet. 1978 Aug; 16(7-8):659-66.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|