 Ribonuclease H, Human Immunodeficiency Virus
"Ribonuclease H, Human Immunodeficiency Virus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ribonuclease activity that is a component of the HIV REVERSE TRANSCRIPTASE. It removes the RNA strand of the RNA-DNA heteroduplex produced by reverse transcription. Once the RNA moiety is removed a double stranded DNA copy of the HIV RNA can be synthesized.
| Descriptor ID |
D054309
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| MeSH Number(s) |
D08.811.277.352.355.350.700.500 D08.811.277.352.700.350.700.500 D12.776.964.775.375.545.875.500 D12.776.964.775.562.764.875.500 D12.776.964.970.600.850.375.545.875.500 D12.776.964.970.600.850.375.750.187.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ribonuclease H, Human Immunodeficiency Virus".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Endonucleases [D08.811.277.352.355]
- Endoribonucleases [D08.811.277.352.355.350]
- Ribonuclease H [D08.811.277.352.355.350.700]
- Ribonuclease H, Human Immunodeficiency Virus [D08.811.277.352.355.350.700.500]
- Ribonucleases [D08.811.277.352.700]
- Endoribonucleases [D08.811.277.352.700.350]
- Ribonuclease H [D08.811.277.352.700.350.700]
- Ribonuclease H, Human Immunodeficiency Virus [D08.811.277.352.700.350.700.500]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Viral Proteins [D12.776.964]
- Retroviridae Proteins [D12.776.964.775]
- Gene Products, pol [D12.776.964.775.375]
- pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.375.545]
- HIV Reverse Transcriptase [D12.776.964.775.375.545.875]
- Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.775.375.545.875.500]
- Human Immunodeficiency Virus Proteins [D12.776.964.775.562]
- pol Gene Products, Human Immunodeficiency Virus [D12.776.964.775.562.764]
- HIV Reverse Transcriptase [D12.776.964.775.562.764.875]
- Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.775.562.764.875.500]
- Viral Structural Proteins [D12.776.964.970]
- Nucleocapsid Proteins [D12.776.964.970.600]
- Viral Core Proteins [D12.776.964.970.600.850]
- Gene Products, pol [D12.776.964.970.600.850.375]
- pol Gene Products, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.545]
- HIV Reverse Transcriptase [D12.776.964.970.600.850.375.545.875]
- Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.545.875.500]
- RNA-Directed DNA Polymerase [D12.776.964.970.600.850.375.750]
- HIV Reverse Transcriptase [D12.776.964.970.600.850.375.750.187]
- Ribonuclease H, Human Immunodeficiency Virus [D12.776.964.970.600.850.375.750.187.500]
Below are MeSH descriptors whose meaning is more specific than "Ribonuclease H, Human Immunodeficiency Virus".
This graph shows the total number of publications written about "Ribonuclease H, Human Immunodeficiency Virus" by people in this website by year, and whether "Ribonuclease H, Human Immunodeficiency Virus" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Ribonuclease H, Human Immunodeficiency Virus" by people in Profiles.
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Esposito F, Sechi M, Pala N, Sanna A, Koneru PC, Kvaratskhelia M, Naesens L, Corona A, Grandi N, di Santo R, D'Amore VM, Di Leva FS, Novellino E, Cosconati S, Tramontano E. Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors. Antiviral Res. 2020 02; 174:104671.
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Velthuisen EJ, Johns BA, Gerondelis P, Chen Y, Li M, Mou K, Zhang W, Seal JW, Hightower KE, Miranda SR, Brown K, Leesnitzer L. Pyridopyrimidinone inhibitors of HIV-1 RNase H. Eur J Med Chem. 2014 Aug 18; 83:609-16.
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Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, G?tte M, Kvaratskhelia M, Le Grice S. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. ACS Chem Biol. 2008 Oct 17; 3(10):635-44.
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